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PMID: 35565254 Published · epublish English Journal Article Review

Glycosyltransferases in Cancer: Prognostic Biomarkers of Survival in Patient Cohorts and Impact on Malignancy in Experimental Models.

Cancers ·Vol. 14 ·No. 9 ·2022-04-24

Pucci M, Duca M, Malagolini N, Dall'Olio F

Abstract

Background: Glycosylation changes are a main feature of cancer. Some carbohydrate epitopes and expression levels of glycosyltransferases have been used or proposed as prognostic markers, while many experimental works have investigated the role of glycosyltransferases in malignancy. Using the transcriptomic data of the 21 TCGA cohorts, we correlated the expression level of 114 glycosyltransferases with the overall survival of patients. Methods: Using the Oncolnc website, we determined the Kaplan−Meier survival curves for the patients falling in the 15% upper or lower percentile of mRNA expression of each glycosyltransferase. Results: Seventeen glycosyltransferases involved in initial steps of N- or O-glycosylation and of glycolipid biosynthesis, in chain extension and sialylation were unequivocally associated with bad prognosis in a majority of cohorts. Four glycosyltransferases were associated with good prognosis. Other glycosyltransferases displayed an extremely high predictive value in only one or a few cohorts. The top were GALNT3, ALG6 and B3GNT7, which displayed a p < 1 × 10−9 in the low-grade glioma (LGG) cohort. Comparison with published experimental data points to ALG3, GALNT2, B4GALNT1, POFUT1, B4GALT5, B3GNT5 and ST3GAL2 as the most consistently malignancy-associated enzymes. Conclusions: We identified several cancer-associated glycosyltransferases as potential prognostic markers and therapeutic targets.

Keywords
Kaplan–Meier survival curves TCGA glycosylation glycosyltransferases transcriptomic analysis
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Pucci Michela
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), General Pathology Building, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy.
Duca Martina
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), General Pathology Building, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy.
Malagolini Nadia
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), General Pathology Building, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy.
Dall'Olio Fabio ORCID
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), General Pathology Building, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy.
References (128)
128 references, click to expand
  1. Glycosylation in cancer: mechanisms and clinical implications.
    Nat Rev Cancer. 2015 Sep;15(9):540-55 PMID: 26289314
  2. GALNT2/14 overexpression correlate with prognosis and methylation: potential therapeutic targets for lung adenocarcinoma.
    Gene. 2021 Jul 20;790:145689 PMID: 33964375
  3. Upregulation of Fucosyltransferase 3, 8 and protein O-Fucosyltransferase 1, 2 genes in esophageal cancer stem-like cells (CSLCs).
    Glycoconj J. 2020 Jun;37(3):319-327 PMID: 32157457
  4. Polypeptide N-acetylgalactosaminyltransferase-Associated Phenotypes in Mammals.
    Molecules. 2021 Sep 10;26(18): PMID: 34576978
  5. Global view of human protein glycosylation pathways and functions.
    Nat Rev Mol Cell Biol. 2020 Dec;21(12):729-749 PMID: 33087899
  6. The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin.
    Hum Mol Genet. 2009 Jul 15;18(14):2599-608 PMID: 19403558
  7. ALG3 contributes to the malignant properties of OSCC cells by regulating CDK-Cyclin pathway.
    Oral Dis. 2021 Sep;27(6):1426-1434 PMID: 33084111
  8. Mechanisms of cancer-associated glycosylation changes.
    Front Biosci (Landmark Ed). 2012 Jan 01;17(2):670-99 PMID: 22201768
  9. Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer.
    Biochim Biophys Acta. 2016 Aug;1860(8):1795-808 PMID: 26721331
  10. Biosynthesis of the major brain gangliosides GD1a and GT1b.
    Glycobiology. 2012 Oct;22(10):1289-301 PMID: 22735313
  11. α-1,3-Fucosyltransferase-VII siRNA inhibits the expression of SLex and hepatocarcinoma cell proliferation.
    Int J Mol Med. 2018 Nov;42(5):2700-2708 PMID: 30226570
  12. Glycosyltransferase Gene Expression Profiles Classify Cancer Types and Propose Prognostic Subtypes.
    Sci Rep. 2016 May 20;6:26451 PMID: 27198045
  13. FUT8 Alpha-(1,6)-Fucosyltransferase in Cancer.
    Int J Mol Sci. 2021 Jan 05;22(1): PMID: 33466384
  14. β-1,4-Galactosyltransferase III suppresses β1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer.
    Carcinogenesis. 2014 Jun;35(6):1258-66 PMID: 24403309
  15. Gene expression profiles in squamous cell cervical carcinoma using array-based comparative genomic hybridization analysis.
    Int J Gynecol Cancer. 2007 May-Jun;17(3):687-96 PMID: 17504382
  16. Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.
    Int J Cancer. 2018 Nov 1;143(9):2319-2330 PMID: 29981167
  17. B3GNT3 acts as a carcinogenic factor in endometrial cancer via facilitating cell growth, invasion and migration through regulating RhoA/RAC1 pathway-associated markers.
    Genes Genomics. 2021 May;43(5):447-457 PMID: 33683574
  18. Long noncoding RNA differentiation antagonizing nonprotein coding RNA promotes the proliferation, invasion and migration of neuroblastoma cells via targeting β-1, 4-galactosyltransferase III by sponging miR-338-3p.
    Neuroreport. 2021 Aug 11;32(12):965-974 PMID: 34050113
  19. Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype.
    Oncotarget. 2017 Jul 18;8(29):47454-47473 PMID: 28537895
  20. Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis.
    J Neurooncol. 2019 Jul;143(3):405-415 PMID: 31104223
  21. Glyco-genes change expression in cancer through aberrant methylation.
    Biochim Biophys Acta. 2016 Aug;1860(8):1776-85 PMID: 26794090
  22. Bioinformatics insight into glycosyltransferase gene expression in gastric cancer: POFUT1 is a potential biomarker.
    Biochem Biophys Res Commun. 2017 Jan 29;483(1):171-177 PMID: 28040433
  23. ST6GalNAc I expression in MDA-MB-231 breast cancer cells greatly modifies their O-glycosylation pattern and enhances their tumourigenicity.
    Glycobiology. 2006 Jan;16(1):54-64 PMID: 16135558
  24. High Expression of the Sda Synthase B4GALNT2 Associates with Good Prognosis and Attenuates Stemness in Colon Cancer.
    Cells. 2020 Apr 11;9(4): PMID: 32290493
  25. B3GNT3 expression suppresses cell migration and invasion and predicts favorable outcomes in neuroblastoma.
    Cancer Sci. 2013 Dec;104(12):1600-8 PMID: 24118321
  26. Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche.
    Cancer Discov. 2015 Feb;5(2):168-81 PMID: 25421439
  27. Global analysis of human glycosyltransferases reveals novel targets for pancreatic cancer pathogenesis.
    Br J Cancer. 2020 May;122(11):1661-1672 PMID: 32203219
  28. Suppression of tumor growth and metastasis in Mgat5-deficient mice.
    Nat Med. 2000 Mar;6(3):306-12 PMID: 10700233
  29. Robust Glycogene-Based Prognostic Signature for Proficient Mismatch Repair Colorectal Adenocarcinoma.
    Front Oncol. 2021 Oct 07;11:727752 PMID: 34692502
  30. Loss and recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions.
    PLoS One. 2012;7(3):e33191 PMID: 22427986
  31. B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells.
    Cancer Lett. 2016 Jun 1;375(2):284-292 PMID: 26987623
  32. The Sda Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition.
    Int J Mol Sci. 2020 Sep 08;21(18): PMID: 32911675
  33. Analysis of the Effect of Increased α2,3-Sialylation on RTK Activation in MKN45 Gastric Cancer Spheroids Treated with Crizotinib.
    Int J Mol Sci. 2020 Jan 22;21(3): PMID: 31979110
  34. Fucosylation genes as circulating biomarkers for lung cancer.
    J Cancer Res Clin Oncol. 2018 Nov;144(11):2109-2115 PMID: 30101373
  35. FUT7 Promotes the Epithelial-Mesenchymal Transition and Immune Infiltration in Bladder Urothelial Carcinoma.
    J Inflamm Res. 2021 Mar 25;14:1069-1084 PMID: 33790621
  36. UDP-Glucose Ceramide Glycosyltransferase Contributes to the Proliferation and Glycolysis of Cervical Cancer Cells by Regulating the PI3K/AKT Pathway.
    Ann Clin Lab Sci. 2021 Sep;51(5):663-669 PMID: 34686508
  37. B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.
    Cell Death Dis. 2013 Jun 06;4:e654 PMID: 23744354
  38. B4GALNT1 promotes progression and metastasis in lung adenocarcinoma through JNK/c-Jun/Slug pathway.
    Carcinogenesis. 2021 Apr 30;42(4):621-630 PMID: 33367717
  39. Glycosyltransferase Gene Expression Identifies a Poor Prognostic Colorectal Cancer Subtype Associated with Mismatch Repair Deficiency and Incomplete Glycan Synthesis.
    Clin Cancer Res. 2018 Sep 15;24(18):4468-4481 PMID: 29844132
  40. Mucin glycosylating enzyme GALNT2 regulates the malignant character of hepatocellular carcinoma by modifying the EGF receptor.
    Cancer Res. 2011 Dec 1;71(23):7270-9 PMID: 21990321
  41. The o-mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophy.
    J Biol Chem. 2013 Mar 8;288(10):6930-5 PMID: 23329833
  42. O-mannosylation and N-glycosylation: two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer.
    Oncotarget. 2016 Oct 4;7(40):65231-65246 PMID: 27533452
  43. POFUT1 acts as a tumor promoter in glioblastoma by enhancing the activation of Notch signaling.
    J Bioenerg Biomembr. 2021 Oct;53(5):621-632 PMID: 34251584
  44. Clinical correlation of B7-H3 and B3GALT4 with the prognosis of colorectal cancer.
    World J Gastroenterol. 2018 Aug 21;24(31):3538-3546 PMID: 30131660
  45. Overexpression of Pofut1 and activated Notch1 may be associated with poor prognosis in breast cancer.
    Biochem Biophys Res Commun. 2017 Sep 9;491(1):104-111 PMID: 28709865
  46. Hsa-miR-370 inhibited P-selectin-induced cell adhesion in human colon adenocarcinoma cells.
    Mol Cell Biochem. 2019 Jan;450(1-2):159-166 PMID: 29922946
  47. B3GNT3 Expression Is a Novel Marker Correlated with Pelvic Lymph Node Metastasis and Poor Clinical Outcome in Early-Stage Cervical Cancer.
    PLoS One. 2015 Dec 28;10(12):e0144360 PMID: 26709519
  48. Functional Characterization of POFUT1 Variants Associated with Colorectal Cancer.
    Cancers (Basel). 2020 May 31;12(6): PMID: 32486426
  49. ALG3 Is Activated by Heat Shock Factor 2 and Promotes Breast Cancer Growth.
    Med Sci Monit. 2018 May 25;24:3479-3487 PMID: 29799832
  50. Sialosignaling: sialyltransferases as engines of self-fueling loops in cancer progression.
    Biochim Biophys Acta. 2014 Sep;1840(9):2752-64 PMID: 24949982
  51. Decreased expression of hepatocyte nuclear factor 4α (Hnf4α)/microRNA-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity.
    J Biol Chem. 2015 Jan 9;290(2):1170-85 PMID: 25422324
  52. ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer.
    J Exp Clin Cancer Res. 2021 Apr 30;40(1):149 PMID: 33931075
  53. The long noncoding RNA DLGAP1-AS2 facilitates cholangiocarcinoma progression via miR-505 and GALNT10.
    FEBS Open Bio. 2021 Feb;11(2):413-422 PMID: 33301605
  54. Saccharide analog, 2-deoxy-d-glucose enhances 4-1BB-mediated antitumor immunity via PD-L1 deglycosylation.
    Mol Carcinog. 2020 Jul;59(7):691-700 PMID: 32115801
  55. B3GNT3 overexpression promotes tumor progression and inhibits infiltration of CD8+ T cells in pancreatic cancer.
    Aging (Albany NY). 2020 Dec 9;13(2):2310-2329 PMID: 33316775
  56. Identifying the prognostic significance of B3GNT3 with PD-L1 expression in lung adenocarcinoma.
    Transl Lung Cancer Res. 2021 Feb;10(2):965-980 PMID: 33718036
  57. Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells.
    BMC Cancer. 2018 Nov 22;18(1):1157 PMID: 30466404
  58. Interleukin-22 regulates B3GNT7 expression to induce fucosylation of glycoproteins in intestinal epithelial cells.
    J Biol Chem. 2022 Feb;298(2):101463 PMID: 34864058
  59. The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis.
    J Biomed Sci. 2020 Jul 3;27(1):77 PMID: 32620165
  60. Derivation and Validation of a Prognostic Model for Cancer Dependency Genes Based on CRISPR-Cas9 in Gastric Adenocarcinoma.
    Front Oncol. 2021 Feb 25;11:617289 PMID: 33732644
  61. B3GNT3 overexpression is associated with unfavourable survival in non-small cell lung cancer.
    J Clin Pathol. 2018 Jul;71(7):642-647 PMID: 29483137
  62. Identification of putative target genes for amplification within 11q13.2 and 3q27.1 in esophageal squamous cell carcinoma.
    Clin Transl Oncol. 2014 Jul;16(7):606-15 PMID: 24203761
  63. ALG3 contributes to the malignancy of non-small cell lung cancer and is negatively regulated by MiR-98-5p.
    Pathol Res Pract. 2020 Mar;216(3):152761 PMID: 31899049
  64. 5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells.
    Clin Epigenetics. 2021 Feb 12;13(1):34 PMID: 33579350
  65. Elevated GALNT10 expression identifies immunosuppressive microenvironment and dismal prognosis of patients with high grade serous ovarian cancer.
    Cancer Immunol Immunother. 2020 Feb;69(2):175-187 PMID: 31853576
  66. Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells.
    Onco Targets Ther. 2017 Aug 07;10:3971-3978 PMID: 28860805
  67. Deglycosylation of PD-L1 by 2-deoxyglucose reverses PARP inhibitor-induced immunosuppression in triple-negative breast cancer.
    Am J Cancer Res. 2018 Sep 01;8(9):1837-1846 PMID: 30323975
  68. B3GNT3: A prognostic biomarker associated with immune cell infiltration in pancreatic adenocarcinoma.
    Oncol Lett. 2021 Feb;21(2):159 PMID: 33552277
  69. Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway.
    Biochem Biophys Res Commun. 2016 Apr 29;473(2):503-10 PMID: 27003260
  70. Mucin glycosylating enzyme GALNT2 suppresses malignancy in gastric adenocarcinoma by reducing MET phosphorylation.
    Oncotarget. 2016 Mar 8;7(10):11251-62 PMID: 26848976
  71. B3GNT3, a Direct Target of miR-149-5p, Promotes Lung Cancer Development and Indicates Poor Prognosis of Lung Cancer.
    Cancer Manag Res. 2020 Mar 31;12:2381-2391 PMID: 32280275
  72. Hypoxia Alters Epigenetic and N-Glycosylation Profiles of Ovarian and Breast Cancer Cell Lines in-vitro.
    Front Oncol. 2020 Jul 29;10:1218 PMID: 32850359
  73. POFUT1 as a Promising Novel Biomarker of Colorectal Cancer.
    Cancers (Basel). 2018 Oct 30;10(11): PMID: 30380753
  74. The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features.
    Breast Cancer Res. 2015 Nov 25;17(1):146 PMID: 26607327
  75. Prognostic value of the FUT family in acute myeloid leukemia.
    Cancer Gene Ther. 2020 Feb;27(1-2):70-80 PMID: 31209266
  76. POFUT1 mRNA expression as an independent prognostic parameter in muscle-invasive bladder cancer.
    Transl Oncol. 2021 Jan;14(1):100900 PMID: 33099185
  77. B4GALNT1 induces angiogenesis, anchorage independence growth and motility, and promotes tumorigenesis in melanoma by induction of ganglioside GM2/GD2.
    Sci Rep. 2020 Jan 27;10(1):1199 PMID: 31988291
  78. Protein O-fucosyltransferase 1: a potential diagnostic marker and therapeutic target for human oral cancer.
    Int J Oncol. 2013 Dec;43(6):1864-70 PMID: 24064921
  79. Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs.
    PLoS One. 2014 Feb 03;9(2):e88124 PMID: 24498430
  80. Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity.
    Cancer Res. 2020 Jun 1;80(11):2298-2310 PMID: 32156778
  81. β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5.
    Glycobiology. 2013 Oct;23(10):1175-83 PMID: 23882130
  82. Elevated histone H3 acetylation and loss of the Sp1-HDAC1 complex de-repress the GM2-synthase gene in renal cell carcinoma.
    J Biol Chem. 2019 Jan 18;294(3):1005-1018 PMID: 30463940
  83. Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling.
    Biomed Pharmacother. 2014 Jul;68(6):785-90 PMID: 25107841
  84. Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression.
    Int J Cancer. 2020 Apr 1;146(7):1979-1992 PMID: 31411736
  85. The GM2 ganglioside inhibits iNKT cell responses in a CD1d-dependent manner.
    Mol Genet Metab. 2018 Sep;125(1-2):161-167 PMID: 30030044
  86. B4GALNT2 Gene Promotes Proliferation, and Invasiveness and Migration Abilities of Model Triple Negative Breast Cancer (TNBC) Cells by Interacting With HLA-B Protein.
    Front Oncol. 2021 Sep 13;11:722828 PMID: 34589428
  87. Recent advancements in understanding mammalian O-mannosylation.
    Glycobiology. 2017 Sep 1;27(9):806-819 PMID: 28810660
  88. Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells.
    Cancer Lett. 2007 May 8;249(2):157-70 PMID: 16965854
  89. Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis.
    Clin Sci (Lond). 2019 May 21;133(10):1167-1184 PMID: 31076460
  90. miR-4299 mediates the invasive properties and tumorigenicity of human follicular thyroid carcinoma by targeting ST6GALNAC4.
    IUBMB Life. 2016 Feb;68(2):136-44 PMID: 26715099
  91. Diagnostic utility of glycosyltransferase mRNA expression in gastric cancer.
    Hematol Oncol Stem Cell Ther. 2018 Sep;11(3):158-168 PMID: 29729225
  92. Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy.
    Cancer Cell. 2019 Aug 12;36(2):168-178.e4 PMID: 31327656
  93. Dual Effect of Combined Metformin and 2-Deoxy-D-Glucose Treatment on Mitochondrial Biogenesis and PD-L1 Expression in Triple-Negative Breast Cancer Cells.
    Cancers (Basel). 2022 Mar 05;14(5): PMID: 35267651
  94. lncRNA MIR4435‑2HG promotes the progression of liver cancer by upregulating B3GNT5 expression.
    Mol Med Rep. 2022 Jan;25(1): PMID: 34859256
  95. B3GNT5 is a novel marker correlated with stem-like phenotype and poor clinical outcome in human gliomas.
    CNS Neurosci Ther. 2020 Nov;26(11):1147-1154 PMID: 32677340
  96. A glycosyltransferase gene signature to detect pancreatic ductal adenocarcinoma patients with poor prognosis.
    EBioMedicine. 2021 Sep;71:103541 PMID: 34425307
  97. "Aberrant sialylation plays a significant role in oral squamous cell carcinoma progression".
    J Oral Pathol Med. 2020 Mar;49(3):253-259 PMID: 31747460
  98. Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.
    Ann Med. 2021 Dec;53(1):916-928 PMID: 34134578
  99. GALNT2 suppresses malignant phenotypes through IGF-1 receptor and predicts favorable prognosis in neuroblastoma.
    Oncotarget. 2014 Dec 15;5(23):12247-59 PMID: 25362349
  100. GD₃ synthase expression enhances proliferation and tumor growth of MDA-MB-231 breast cancer cells through c-Met activation.
    Mol Cancer Res. 2010 Nov;8(11):1526-35 PMID: 20889649
  101. BAG3 epigenetically regulates GALNT10 expression via WDR5 and facilitates the stem cell-like properties of platin-resistant ovarian cancer cells.
    Biochim Biophys Acta Mol Cell Res. 2021 Aug;1868(9):119077 PMID: 34111434
  102. B4GALT3 promotes cell proliferation and invasion in glioblastoma.
    Neurol Res. 2020 Jun;42(6):463-470 PMID: 32202233
  103. β1,4-Galactosyltransferase V Modulates Breast Cancer Stem Cells through Wnt/β-catenin Signaling Pathway.
    Cancer Res Treat. 2020 Oct;52(4):1084-1102 PMID: 32599982
  104. Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways.
    Biochim Biophys Acta. 2015 Sep;1852(9):1928-39 PMID: 26144047
  105. GALNT2 enhances migration and invasion of oral squamous cell carcinoma by regulating EGFR glycosylation and activity.
    Oral Oncol. 2014 May;50(5):478-84 PMID: 24582885
  106. Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.
    PLoS One. 2013 Jun 14;8(6):e66737 PMID: 23799130
  107. Protein O-fucosylation: structure and function.
    Curr Opin Struct Biol. 2019 Jun;56:78-86 PMID: 30690220
  108. Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma.
    Cell Death Dis. 2019 Jun 17;10(7):477 PMID: 31209283
  109. TALEN mediated targeted editing of GM2/GD2-synthase gene modulates anchorage independent growth by reducing anoikis resistance in mouse tumor cells.
    Sci Rep. 2015 Mar 12;5:9048 PMID: 25762467
  110. Glycosylation as a Main Regulator of Growth and Death Factor Receptors Signaling.
    Int J Mol Sci. 2018 Feb 15;19(2): PMID: 29462882
  111. Prediction of bladder cancer based on urinary content of MGEA5 and OGT mRNA level.
    Clin Lab. 2012;58(5-6):579-83 PMID: 22783592
  112. PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness.
    EBioMedicine. 2019 Jul;45:124-138 PMID: 31279780
  113. Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.
    Cancer Cell. 2018 Feb 12;33(2):187-201.e10 PMID: 29438695
  114. Role and Function of O-GlcNAcylation in Cancer.
    Cancers (Basel). 2021 Oct 26;13(21): PMID: 34771527
  115. Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells.
    Glycobiology. 2014 Apr;24(4):359-67 PMID: 24418929
  116. FUT7 promotes the malignant transformation of follicular thyroid carcinoma through α1,3-fucosylation of EGF receptor.
    Exp Cell Res. 2020 Aug 15;393(2):112095 PMID: 32442537
  117. Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia progression through modulating B4GALT5 expression and PI3K/AKT signaling pathway.
    Int J Lab Hematol. 2022 Apr;44(2):320-332 PMID: 34709725
  118. Suppressed OGT expression inhibits cell proliferation while inducing cell apoptosis in bladder cancer.
    BMC Cancer. 2018 Nov 20;18(1):1141 PMID: 30453909
  119. GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
    Life Sci. 2021 Jul 1;276:119439 PMID: 33785338
  120. Sialyltransferases in cancer.
    Glycoconj J. 2001 Nov-Dec;18(11-12):841-50 PMID: 12820717
  121. POFUT1 promotes colorectal cancer development through the activation of Notch1 signaling.
    Cell Death Dis. 2018 Sep 24;9(10):995 PMID: 30250219
  122. Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells.
    Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):4968-73 PMID: 23479608
  123. Glycosyltransferase B4GALNT2 as a Predictor of Good Prognosis in Colon Cancer: Lessons from Databases.
    Int J Mol Sci. 2021 Apr 21;22(9): PMID: 33919332
  124. Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway.
    Biochim Biophys Acta. 2016 Jul;1863(7 Pt A):1472-89 PMID: 27066976
  125. Fucosylation in cancer biology and its clinical applications.
    Prog Mol Biol Transl Sci. 2019;162:93-119 PMID: 30905466
  126. Type 2 diabetes mellitus facilitates endometrial hyperplasia progression by activating the proliferative function of mucin O-glycosylating enzyme GALNT2.
    Biomed Pharmacother. 2020 Nov;131:110764 PMID: 33152927
  127. β-1,4-Galactosyltransferase III enhances invasive phenotypes via β1-integrin and predicts poor prognosis in neuroblastoma.
    Clin Cancer Res. 2013 Apr 1;19(7):1705-16 PMID: 23444218
  128. Biological roles of glycans.
    Glycobiology. 2017 Jan;27(1):3-49 PMID: 27558841
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Article Info
Journal
Cancers
Abbr.
Cancers (Basel)
ISSN
2072-6694
DOI
10.3390/cancers14092128
Published
2022-04-24
Epub
2022-00-24
Language
English
Region
Switzerland
NLM ID
101526829
PMCID
PMC9100214
External Links
PubMed source DOI: 10.3390/cancers14092128 PMC Full Text View journal details
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