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PMID: 3327632 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The structural relationship of blood group-related oligosaccharides in human carcinoma to biological function: a perspective.

Cancer metastasis reviews ·Vol. 6 ·No. 4 ·1987-00-00 ·Pages 541-57

Dube VE

Abstract

Blood group-related oligosaccharides have been isolated from a limited number of carcinomas. The carcinoma-associated oligosaccharides show chain elongation, for example due to repeating Gal 1,4 GlcNAc 1,3 sequences, or a higher degree of branching, which permit increased sialylation and fucosylation. Abnormal carbohydrate structures have been demonstrated on tumor cell membranes by immunological techniques, which suggests deletion of ABH, accumulation of 'crypt' antigens such as I and T antigens, and abnormal expression of Lewis antigens. Changes in carcinoma-associated oligosaccharides can result from altered biosynthetic processing in the Golgi apparatus or the occurrence of abnormal tumor glycosyltransferase isoenzymes. Structural alterations of oligosaccharides on the tumor cell membrane are related to the regulation of tumor growth, cell-cell interaction, cell differentiation, and metastasis. Glycoproteins secreted by tumor cells into the circulation evoke cellular and humoral immunity and cause immune suppression by binding to cytotoxic T lymphocytes and lymphocyte subsets. The relationship of oligosaccharide structures to biologic function awaits elucidation.

MeSH Terms
Animals Blood Group Antigens/immunology Cell Membrane/metabolism Glycoproteins/blood Glycosylation Humans Mucins/metabolism Neoplasms/immunology,metabolism,pathology Oligosaccharides/metabolism,physiology Structure-Activity Relationship Transferases/metabolism
Chemicals
Blood Group Antigens Glycoproteins Mucins Oligosaccharides Transferases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Dube V E
Department of Pathology and Laboratory Medicine, Evanston Hospital, IL 60201.
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Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00047467
Published
1987-00-00
Pages
541-57
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
Grants
NCI NIH HHS · CA 38878 · United States
External Links
PubMed source DOI: 10.1007/BF00047467 View journal details
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