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PMID: 2416588 Published · ppublish English Journal Article Retracted Publication

Cytotoxicity of human peripheral blood T-lymphocyte clones activated by hepatitis B virus surface antigen.

Experientia ·Vol. 41 ·No. 12 ·1985-12-15 ·Pages 1579-84

Hakim AA

Abstract

The present studies examined the cytotoxic activities of peripheral blood lymphocytes (PBL) from volunteers with (sero-positive) and without (sero-negative) circulating antibodies to hepatitis B virus surface antigen before and 30 days after vaccination with hepatitis B virus surface antigen (HBsAg). Long-term culture of monospecific hepatitis B surface (HBsAg)-responsive T-lymphocytes were isolated and grown in large numbers. The mechanism of T-cell mediated cytolysis, and the identification of the carbohydrate determinants on the surface of these effector cells responsible for the killing effect, are being examined.

MeSH Terms
Carbohydrates/analysis Cells, Cultured Cytotoxicity, Immunologic Epitopes/analysis Hepatitis B/immunology Hepatitis B Antibodies/immunology Hepatitis B Surface Antigens/immunology Humans Killer Cells, Natural/immunology Lymphocyte Activation T-Lymphocytes, Cytotoxic/immunology Viral Vaccines/immunology
Chemicals
Carbohydrates Epitopes Hepatitis B Antibodies Hepatitis B Surface Antigens Viral Vaccines
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hakim A A
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30 references, click to expand
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01964817
Published
1985-12-15
Pages
1579-84
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
Corrections
RetractionIn
PMID: 2189745
External Links
PubMed source DOI: 10.1007/BF01964817
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