Home LiteratureArticle Details
PMID: 3012465 Published · ppublish English Comparative Study Journal Article

DNA sequence of the herpes simplex virus type 1 gene encoding glycoprotein gH, and identification of homologues in the genomes of varicella-zoster virus and Epstein-Barr virus.

Nucleic acids research ·Vol. 14 ·No. 10 ·1986-05-27 ·Pages 4281-92

McGeoch DJ, Davison AJ

Abstract

We have determined the sequence of herpes simplex virus type 1 DNA around the previously mapped location of sequences encoding an epitope of glycoprotein gH, and have deduced the structure of the gH gene and the amino acid sequence of gH. The unprocessed polypeptide is predicted to contain 838 amino acids, and to possess an N-terminal signal sequence and a C-terminal transmembrane sequence. Temperature-sensitive mutant tsQ26 maps within the predicted gH coding sequence. Homologous genes were identified in the genomes of two other herpesviruses, namely varicella-zoster virus and Epstein-Barr virus.

MeSH Terms
Amino Acid Sequence Base Sequence DNA, Viral/analysis Herpesvirus 3, Human/genetics Herpesvirus 4, Human/genetics Mutation Simplexvirus/genetics Temperature Viral Envelope Proteins/genetics
Chemicals
DNA, Viral Viral Envelope Proteins glycoprotein H, herpes simplex virus type 1
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McGeoch D J
Davison A J
References (32)
32 references, click to expand
  1. On the predictive recognition of signal peptide sequences.
    Virus Res. 1985 Oct;3(3):271-86 PMID: 3000102
  2. DNA sequence of the region in the genome of herpes simplex virus type 1 containing the genes for DNA polymerase and the major DNA binding protein.
    Nucleic Acids Res. 1985 Nov 25;13(22):8143-63 PMID: 2999714
  3. Physical mapping of herpes simplex virus-induced polypeptides.
    J Virol. 1978 Nov;28(2):624-42 PMID: 214583
  4. The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene.
    Nucleic Acids Res. 1980 Dec 20;8(24):5949-64 PMID: 6258156
  5. Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1.
    Proc Natl Acad Sci U S A. 1981 Mar;78(3):1441-5 PMID: 6262799
  6. Synthesis and processing of asparagine-linked oligosaccharides.
    Annu Rev Biochem. 1981;50:555-83 PMID: 7023366
  7. Monoclonal antibodies to herpes simplex virus type 1 proteins, including the immediate-early protein ICP 4.
    Infect Immun. 1981 Dec;34(3):684-92 PMID: 6277788
  8. Production and characterization of monoclonal antibodies against the Epstein-Barr virus membrane antigen.
    J Virol. 1982 Jan;41(1):258-64 PMID: 6177865
  9. A simple method for displaying the hydropathic character of a protein.
    J Mol Biol. 1982 May 5;157(1):105-32 PMID: 7108955
  10. Thymidine kinase deletion mutants of herpes simplex virus type 1.
    J Gen Virol. 1982 Dec;63(2):277-95 PMID: 6296278
  11. Transcription of herpes simplex virus genes in vivo: overlap of a late promoter with the 3' end of the early thymidine kinase gene.
    J Virol. 1983 Jan;45(1):10-7 PMID: 6296424
  12. Synthesis and processing of the three major envelope glycoproteins of Epstein-Barr virus.
    J Virol. 1983 May;46(2):547-56 PMID: 6302318
  13. Patterns of amino acids near signal-sequence cleavage sites.
    Eur J Biochem. 1983 Jun 1;133(1):17-21 PMID: 6852022
  14. A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides.
    J Mol Biol. 1983 Jun 25;167(2):391-409 PMID: 6345794
  15. Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment.
    Virology. 1983 Oct 30;130(2):290-305 PMID: 6316633
  16. A fast homology program for aligning biological sequences.
    Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):447-55 PMID: 6546428
  17. Identification and preliminary mapping with monoclonal antibodies of a herpes simplex virus 2 glycoprotein lacking a known type 1 counterpart.
    Virology. 1984 Feb;133(1):242-7 PMID: 6199891
  18. Characterization of the 92,000-dalton glycoprotein induced by herpes simplex virus type 2.
    J Virol. 1984 May;50(2):547-54 PMID: 6323754
  19. Nucleotide sequence specifying the glycoprotein gene, gB, of herpes simplex virus type 1.
    Virology. 1984 Mar;133(2):301-14 PMID: 6324454
  20. Transcription and DNA sequence of the BamHI L fragment of B95-8 Epstein-Barr virus.
    EMBO J. 1984 May;3(5):1083-90 PMID: 6203743
  21. Homology between two EBV early genes and HSV ribonucleotide reductase and 38K genes.
    Nucleic Acids Res. 1984 Jun 25;12(12):5087-99 PMID: 6330697
  22. DNA sequence and expression of the B95-8 Epstein-Barr virus genome.
    Nature. 1984 Jul 19-25;310(5974):207-11 PMID: 6087149
  23. Molecular basis of the glycoprotein-C-negative phenotype of herpes simplex virus type 1 macroplaque strain.
    J Virol. 1984 Sep;51(3):578-85 PMID: 6088783
  24. Use of a bacterial expression vector to map the varicella-zoster virus major glycoprotein gene, gC.
    J Virol. 1985 Jan;53(1):81-8 PMID: 2981365
  25. Characterisation and physical mapping of an HSV-1 glycoprotein of approximately 115 X 10(3) molecular weight.
    Virology. 1984 Dec;139(2):408-13 PMID: 6097034
  26. Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1.
    J Mol Biol. 1985 Jan 5;181(1):1-13 PMID: 2984429
  27. An unusual spliced herpes simplex virus type 1 transcript with sequence homology to Epstein-Barr virus DNA.
    J Virol. 1985 May;54(2):317-28 PMID: 2985801
  28. Two major outer envelope glycoproteins of Epstein-Barr virus are encoded by the same gene.
    J Virol. 1985 Jun;54(3):665-74 PMID: 2987520
  29. Identification of the products of a varicella-zoster virus glycoprotein gene.
    J Gen Virol. 1985 Oct;66 ( Pt 10):2237-42 PMID: 2995558
  30. Multiple mechanisms of protein insertion into and across membranes.
    Science. 1985 Oct 25;230(4724):400-7 PMID: 4048938
  31. Epstein-Barr virus genome may encode a protein showing significant amino acid and predicted secondary structure homology with glycoprotein B of herpes simplex virus 1.
    J Virol. 1985 Dec;56(3):807-13 PMID: 2999435
  32. Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1.
    Nucleic Acids Res. 1986 Feb 25;14(4):1727-45 PMID: 3005980
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/14.10.4281
Published
1986-05-27
Pages
4281-92
Language
English
Region
England
NLM ID
0411011
PMCID
PMC339861
Subset
IM
Databases
GENBANK
X03896
External Links
PubMed source DOI: 10.1093/nar/14.10.4281 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2