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PMID: 27339708 Published · ppublish English Journal Article Review

The role of myeloid cells in cancer therapies.

Nature reviews. Cancer ·Vol. 16 ·No. 7 ·2016-00-00 ·Pages 447-62

Engblom C, Pfirschke C, Pittet MJ

Abstract

Recent clinical trials have demonstrated the ability to durably control cancer in some patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer treatment but benefit only a minority of patients. It is thus a crucial time for clinicians, cancer scientists and immunologists to determine the next steps in shifting cancer treatment towards better cancer control. This Review describes recent advances in our understanding of tumour-associated myeloid cells. These cells remain less studied than T lymphocytes but have attracted particular attention because their presence in tumours is often linked to altered patient survival. Also, experimental studies indicate that myeloid cells modulate key cancer-associated activities, including immune evasion, and affect virtually all types of cancer therapy. Consequently, targeting myeloid cells could overcome limitations of current treatment options.

MeSH Terms
Humans Immunity, Innate Immunotherapy Myeloid Cells/cytology Neoplasms/immunology,therapy Tumor Microenvironment
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Engblom Camilla
Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts 02114, USA. | Graduate Program in Immunology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Pfirschke Christina
Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts 02114, USA.
Pittet Mikael J
Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts 02114, USA.
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc.2016.54
Published
2016-00-00
Pages
447-62
Language
English
Region
England
NLM ID
101124168
Subset
IM
Grants
NIAID NIH HHS · R01 AI084880 · United States
External Links
PubMed source DOI: 10.1038/nrc.2016.54 View journal details
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