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PMID: 24673186 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The journey from stem cell to macrophage.

Annals of the New York Academy of Sciences ·Vol. 1319 ·2014-06-00 ·Pages 1-18

Pittet MJ, Nahrendorf M, Swirski FK

Abstract

Essential protectors against infection and injury, macrophages can also contribute to many common and fatal diseases. Here, we discuss the mechanisms that control different types of macrophage activities in mice. We follow the cells' maturational pathways over time and space and elaborate on events that influence the type of macrophage eventually settling a particular destination. The nature of the precursor cells, developmental niches, tissues, environmental cues, and other connecting processes appear to contribute to the identity of macrophage type. Together, the spatial and developmental relationships of macrophages compose a topo-ontogenic map that can guide our understanding of their biology.

Keywords
hematopoesis macrophage monocyte
MeSH Terms
Animals Cell Differentiation/immunology Humans Macrophage Activation/immunology Macrophages/cytology,immunology,pathology Stem Cells/cytology,immunology,pathology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pittet Mikael J
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Nahrendorf Matthias
Swirski Filip K
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Article Info
Journal
Annals of the New York Academy of Sciences
Abbr.
Ann N Y Acad Sci
ISSN
1749-6632
DOI
10.1111/nyas.12393
Published
2014-06-00
Epub
2014-00-27
Pages
1-18
Language
English
Region
United States
NLM ID
7506858
PMCID
PMC4074243
Subset
IM
Grants
NHLBI NIH HHS · R01 HL095612 · United States
NIAID NIH HHS · R56 AI104695 · United States
NIAID NIH HHS · R01 AI084880 · United States
NIAID NIH HHS · R56-AI104695 · United States
NCI NIH HHS · P50 CA086355 · United States
NCI NIH HHS · P50-CA086355 · United States
NIAID NIH HHS · R01-AI084880 · United States
NHLBI NIH HHS · R01 HL096576 · United States
NHLBI NIH HHS · R01-HL095612 · United States
NCI NIH HHS · U54 CA126515 · United States
NCI NIH HHS · U54-CA126515 · United States
NHLBI NIH HHS · R01-HL096576 · United States
NHLBI NIH HHS · R01 HL095629 · United States
NHLBI NIH HHS · R01-HL095629 · United States
External Links
PubMed source DOI: 10.1111/nyas.12393 PMC Full Text View journal details
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