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PMID: 22699831 Published · epublish English Journal Article Review

Information processing during phagocytosis.

Nature reviews. Immunology ·Vol. 12 ·No. 7 ·2012-06-15 ·Pages 492-502

Underhill DM, Goodridge HS

Abstract

Phagocytosis - the process by which macrophages, dendritic cells and other myeloid phagocytes internalize diverse particulate targets - is a key mechanism of innate immunity. The molecular and cellular events that underlie the binding of targets to a phagocyte and their engulfment into phagosomes have been extensively studied. More recent data suggest that the process of phagocytosis itself provides information to myeloid phagocytes about the nature of the targets they are engulfing and that this helps to tailor inflammatory responses. In this Review, we discuss how such information is acquired during phagocytosis and how it is processed to coordinate an immune response.

MeSH Terms
Animals Humans Immunity, Innate Inflammasomes/immunology Macrophages/immunology,microbiology Models, Immunological Myeloid Cells/immunology,microbiology Phagocytes/immunology,microbiology Phagocytosis/immunology Receptors, Immunologic/immunology Signal Transduction/immunology Toll-Like Receptors/immunology
Chemicals
Inflammasomes Receptors, Immunologic Toll-Like Receptors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Underhill David M
Inflammatory Bowel & Immunobiology Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8,700 Beverly Boulevard, Los Angeles, California 90048, USA. David.Underhill@csmc.edu
Goodridge Helen S
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri3244
Email
david.underhill@csmc.edu
Published
2012-06-15
Epub
2012-00-15
Pages
492-502
Language
English
Region
England
NLM ID
101124169
PMCID
PMC5570470
Subset
IM
Grants
NIGMS NIH HHS · R01 GM085796 · United States
External Links
PubMed source DOI: 10.1038/nri3244 PMC Full Text View journal details
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