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PMID: 21904389 Published · epublish English Journal Article Research Support, N.I.H., Extramural Review

New insights into the T cell synapse from single molecule techniques.

Nature reviews. Immunology ·Vol. 11 ·No. 10 ·2011-09-09 ·Pages 672-84

Dustin ML, Depoil D

Abstract

T cell activation depends on extracellular ligation of the T cell receptor (TCR) by peptide-MHC complexes in a synapse between the T cell and an antigen-presenting cell. The process then requires the assembly of signalling complexes between the TCR and the adaptor protein linker for activation of T cells (LAT), and subsequent filamentous actin (F-actin)-dependent TCR cluster formation. Recent progress in each of these areas, made possible by the emergence of new techniques, has forced us to rethink our assumptions and consider some radical new models. These describe the receptor interaction parameters that control T cell responses and the mechanism by which LAT is recruited to the TCR signalling machinery. This is an exciting time in T cell biology, and further innovation in imaging and genomics is likely to lead to a greater understanding of how T cells are activated.

MeSH Terms
Actins/genetics,immunology,metabolism Adaptor Proteins, Signal Transducing/genetics,immunology,metabolism Animals Antigen-Presenting Cells/immunology,metabolism Cytological Techniques/methods Humans Immunity Immunological Synapses/chemistry,metabolism Lymphocyte Activation/genetics,immunology Major Histocompatibility Complex Mice Molecular Imaging/methods Receptors, Antigen, T-Cell/genetics,immunology,metabolism Signal Transduction/genetics,immunology T-Lymphocytes/chemistry,cytology,immunology,metabolism
Chemicals
Actins Adaptor Proteins, Signal Transducing Receptors, Antigen, T-Cell
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dustin Michael L
Helene and Martin Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, New York 10012, USA. michael.dustin@med.nyu.edu
Depoil David
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri3066
Email
michael.dustin@med.nyu.edu
Published
2011-09-09
Epub
2011-00-09
Pages
672-84
Language
English
Region
England
NLM ID
101124169
PMCID
PMC3889200
Subset
IM
Grants
NIAID NIH HHS · P01 AI045757 · United States
NEI NIH HHS · PN2 EY016586 · United States
NIAID NIH HHS · R37 AI043542 · United States
NIAID NIH HHS · R01 AI043549 · United States
External Links
PubMed source DOI: 10.1038/nri3066 PMC Full Text View journal details
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