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PMID: 26546518 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

The Transporter Classification Database (TCDB): recent advances.

Nucleic acids research ·Vol. 44 ·No. D1 ·2016-01-04 ·Pages D372-9

Saier MH, Reddy VS, Tsu BV, Ahmed MS, Li C, Moreno-Hagelsieb G

Abstract

The Transporter Classification Database (TCDB; http://www.tcdb.org) is a freely accessible reference database for transport protein research, which provides structural, functional, mechanistic, evolutionary and disease/medical information about transporters from organisms of all types. TCDB is the only transport protein classification database adopted by the International Union of Biochemistry and Molecular Biology (IUBMB). It consists of more than 10,000 non-redundant transport systems with more than 11 000 reference citations, classified into over 1000 transporter families. Transporters in TCDB can be single or multi-component systems, categorized in a functional/phylogenetic hierarchical system of classes, subclasses, families, subfamilies and transport systems. TCDB also includes updated software designed to analyze the distinctive features of transport proteins, extending its usefulness. Here we present a comprehensive update of the database contents and features and summarize recent discoveries recorded in TCDB.

MeSH Terms
Databases, Protein Membrane Transport Proteins/chemistry,classification,metabolism Sequence Analysis, Protein
Chemicals
Membrane Transport Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Saier Milton H
Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093-0116, USA msaier@ucsd.edu.
Reddy Vamsee S
Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093-0116, USA Department of Medical Sciences, Boston University School of Medicine, 72 E Concord St., Boston, MA 02118, USA.
Tsu Brian V
Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093-0116, USA.
Ahmed Muhammad Saad
Department of Biological Engineering, School of Life Sciences, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
Li Chun
Department of Biological Engineering, School of Life Sciences, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
Moreno-Hagelsieb Gabriel
Department of Molecular Biology, University of California at San Diego, La Jolla, CA 92093-0116, USA Department of Biology, Wilfrid Laurier University, 75 University Ave W, Waterloo, ON, Canada N2L 3C5.
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
DOI
10.1093/nar/gkv1103
Email
msaier@ucsd.edu
Published
2016-01-04
Epub
2015-00-05
Pages
D372-9
Language
English
Region
England
NLM ID
0411011
PMCID
PMC4702804
Subset
IM
Grants
NIGMS NIH HHS · R01 GM077402 · United States
NIGMS NIH HHS · GM 077402 · United States
NIGMS NIH HHS · GM077402 · United States
External Links
PubMed source DOI: 10.1093/nar/gkv1103 PMC Full Text View journal details
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