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PMID: 19827947 Published · ppublish English Historical Article Journal Article Review

Chloride channels: often enigmatic, rarely predictable.

Annual review of physiology ·Vol. 72 ·2010-00-00 ·Pages 95-121

Duran C, Thompson CH, Xiao Q, Hartzell HC

Abstract

Until recently, anion (Cl(-)) channels have received considerably less attention than cation channels. One reason for this may be that many Cl(-) channels perform functions that might be considered cell-biological, like fluid secretion and cell volume regulation, whereas cation channels have historically been associated with cellular excitability, which typically happens more rapidly. In this review, we discuss the recent explosion of interest in Cl(-) channels, with special emphasis on new and often surprising developments over the past five years. This is exemplified by the findings that more than half of the ClC family members are antiporters, and not channels, as was previously thought, and that bestrophins, previously prime candidates for Ca(2+)-activated Cl(-) channels, have been supplanted by the newly discovered anoctamins and now hold a tenuous position in the Cl(-) channel world.

MeSH Terms
Amino Acid Sequence Carrier Proteins/metabolism Channelopathies/physiopathology Chloride Channels/classification,drug effects,genetics,physiology History, 20th Century Humans Neoplasms/genetics,pathology Physiology/history
Chemicals
Carrier Proteins Chloride Channels
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Duran Charity
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Thompson Christopher H
Xiao Qinghuan
Hartzell H Criss
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Article Info
Journal
Annual review of physiology
Abbr.
Annu Rev Physiol
ISSN
1545-1585
DOI
10.1146/annurev-physiol-021909-135811
Published
2010-00-00
Pages
95-121
Language
English
Region
United States
NLM ID
0370600
PMCID
PMC2851227
Subset
IM
Grants
NEI NIH HHS · P30 EY006360 · United States
NEI NIH HHS · R01 EY014852-06 · United States
NIGMS NIH HHS · R01 GM060448-08 · United States
NEI NIH HHS · T32 EY007092 · United States
NIGMS NIH HHS · R01 GM060448 · United States
NEI NIH HHS · R01 EY014852 · United States
External Links
PubMed source DOI: 10.1146/annurev-physiol-021909-135811 PMC Full Text View journal details
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