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PMID: 19015192 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.

The Journal of physiology ·Vol. 587 ·No. Pt 10 ·2009-05-15 ·Pages 2127-39

Hartzell HC, Yu K, Xiao Q, Chien LT, Qu Z

Abstract

Ca(2+)-activated Cl- channels (CaCCs) perform many important functions in cell physiology including secretion of fluids from acinar cells of secretory glands, amplification of olfactory transduction, regulation of cardiac and neuronal excitability, mediation of the fast block to polyspermy in amphibian oocytes, and regulation of vascular tone. Although a number of proteins have been proposed to be responsible for CaCC currents, the anoctamin family (ANO, also known as TMEM16) exhibits characteristics most similar to those expected for the classical CaCC. Interestingly, this family of proteins has previously attracted the interest of both developmental and cancer biologists. Some members of this family are up-regulated in a number of tumours and functional deficiency in others is linked to developmental defects.

MeSH Terms
Animals Anoctamin-1 Chloride Channels/chemistry,physiology Electrophysiological Phenomena/physiology Growth and Development/physiology Humans Ion Channel Gating/physiology Membrane Proteins/chemistry,physiology Neoplasm Proteins/chemistry,physiology Neoplasms/metabolism Phylogeny
Chemicals
ANO1 protein, human Anoctamin-1 Chloride Channels Membrane Proteins Neoplasm Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hartzell H Criss
Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, 535 Whitehead Bldg, Atlanta, GA 30322, USA. criss.hartzell@emory.edu
Yu Kuai
Xiao Qinhuan
Chien Li-Ting
Qu Zhiqiang
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
1469-7793
DOI
10.1113/jphysiol.2008.163709
Email
criss.hartzell@emory.edu
Published
2009-05-15
Epub
2008-00-17
Pages
2127-39
Language
English
Region
England
NLM ID
0266262
PMCID
PMC2697287
Subset
IM
Grants
NIGMS NIH HHS · R01 GM060448-08 · United States
NEI NIH HHS · R01 EY014852-08 · United States
NIGMS NIH HHS · R01 GM060448 · United States
NEI NIH HHS · EY014852 · United States
NEI NIH HHS · R01 EY014852 · United States
NIGMS NIH HHS · GM60448 · United States
External Links
PubMed source DOI: 10.1113/jphysiol.2008.163709 PMC Full Text View journal details
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