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PMID: 26474485 Published · epublish English Journal Article Research Support, N.I.H., Extramural

The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis.

PloS one ·Vol. 10 ·No. 10 ·2015-00-00 ·Pages e0137184

Tsu BV, Saier MH

Abstract

The LysE superfamily consists of transmembrane transport proteins that catalyze export of amino acids, lipids and heavy metal ions. Statistical means were used to show that it includes newly identified families including transporters specific for (1) tellurium, (2) iron/lead, (3) manganese, (4) calcium, (5) nickel/cobalt, (6) amino acids, and (7) peptidoglycolipids as well as (8) one family of transmembrane electron carriers. Internal repeats and conserved motifs were identified, and multiple alignments, phylogenetic trees and average hydropathy, amphipathicity and similarity plots provided evidence that all members of the superfamily derived from a single common 3-TMS precursor peptide via intragenic duplication. Their common origin implies that they share common structural, mechanistic and functional attributes. The transporters of this superfamily play important roles in ionic homeostasis, cell envelope assembly, and protection from excessive cytoplasmic heavy metal/metabolite concentrations. They thus influence the physiology and pathogenesis of numerous microbes, being potential targets of drug action.

MeSH Terms
Bacteria/genetics,pathogenicity Bacterial Proteins/genetics Databases, Protein Evolution, Molecular Gene Duplication Membrane Transport Proteins/genetics Phylogeny Sequence Alignment
Chemicals
Bacterial Proteins Membrane Transport Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tsu Brian V
Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California, United States of America.
Saier Milton H
Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California, United States of America.
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Article Info
Journal
PloS one
Abbr.
PLoS One
ISSN
1932-6203
DOI
10.1371/journal.pone.0137184
Published
2015-00-00
Epub
2015-00-16
Pages
e0137184
Language
English
Region
United States
NLM ID
101285081
PMCID
PMC4608589
Subset
IM
Grants
NIGMS NIH HHS · R01 GM077402 · United States
NIGMS NIH HHS · GM077402 · United States
External Links
PubMed source DOI: 10.1371/journal.pone.0137184 PMC Full Text View journal details
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