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PMID: 25650800 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Transcription termination and the control of the transcriptome: why, where and how to stop.

Nature reviews. Molecular cell biology ·Vol. 16 ·No. 3 ·2015-03-00 ·Pages 190-202

Porrua O, Libri D

Abstract

Transcription termination occurs when the polymerase is released after a transcription event, thus delimitating transcription units; however, the functional importance of termination extends beyond the mere definition of gene borders. By determining the cellular fate of the generated transcripts, transcription termination pathways shape the transcriptome. Recent reports have underscored the crucial role of these pathways in limiting the extent of pervasive transcription, which has attracted interest in post-initiation events in gene expression control. Transcription termination pathways involved in the production of non-coding RNAs - such as the Nrd1-Nab3-Sen1 (NNS) pathway in yeast and the cap-binding complex (CBC)-ARS2 pathway in humans - are key determinants of transcription quality control. Understanding the mechanisms leading to the timely and efficient dismantling of elongation complexes remains a major unmet challenge, but new insights into the molecular basis of termination at mRNA-coding and non-coding RNA gene targets have been gained in eukaryotes.

MeSH Terms
Animals DNA Helicases/genetics,metabolism Gene Expression Regulation Humans Nuclear Proteins/genetics,metabolism RNA Cap-Binding Proteins/genetics,metabolism RNA Helicases/genetics,metabolism RNA Polymerase II/genetics,metabolism RNA-Binding Proteins/genetics,metabolism Saccharomyces cerevisiae/genetics,metabolism Saccharomyces cerevisiae Proteins/genetics,metabolism Signal Transduction Transcription Termination, Genetic Transcriptome
Chemicals
NAB3 protein, S cerevisiae NRD1 protein, S cerevisiae Nuclear Proteins RNA Cap-Binding Proteins RNA-Binding Proteins Saccharomyces cerevisiae Proteins RNA Polymerase II SEN1 protein, S cerevisiae DNA Helicases RNA Helicases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Porrua Odil
Institut Jacques Monod, Centre Nationale pour la Recherche Scientifique (CNRS), UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France.
Libri Domenico
Institut Jacques Monod, Centre Nationale pour la Recherche Scientifique (CNRS), UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France.
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm3943
Published
2015-03-00
Epub
2015-00-04
Pages
190-202
Language
English
Region
England
NLM ID
100962782
Subset
IM
External Links
PubMed source DOI: 10.1038/nrm3943 View journal details
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