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PMID: 2474673 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activator tax.

Journal of virology ·Vol. 63 ·No. 9 ·1989-09-00 ·Pages 3761-8

Tan TH, Jia R, Roeder RG

Abstract

The human T-cell leukemia virus type I (HTLV-I) trans-activator (tax)-inducible enhancer was localized to three copies of 21-base-pair repeats within the long terminal repeat. Interestingly, the TGACG motif found in the center of the 21-base-pair tax-responsive element (TRE) is also present in the cyclic AMP (cAMP)-responsive elements (CREs) and activating transcription factor (ATF)-binding sites. In this study, we demonstrate that the three TRE-binding proteins, TREB-1, TREB-2, and TREB-3, also bind to various CREs and ATF-binding sites and that the TREs can confer upon a heterologous promoter responsiveness to various inducing agents, including tax, cAMP, and E1a. Furthermore, the transcriptional activation of the HTLV-I promoter by tax can be inhibited by several protein kinase inhibitors, including sangivamycin. Our results indicate that the TREs, CREs, and ATF-binding sites are similar cis-acting elements and further suggest (i) that the transcriptional activation of the HTLV-I promoter by tax involves the action of a protein kinase and (ii) that induction by tax, cAMP, and E1a might be mediated by distinct factors or kinases.

MeSH Terms
1-Methyl-3-isobutylxanthine/pharmacology Adenovirus Early Proteins Binding Sites Carrier Proteins/metabolism Cyclic AMP/biosynthesis,pharmacology Gene Products, tat Human T-lymphotropic virus 1/genetics Oncogene Proteins, Viral/pharmacology Promoter Regions, Genetic Protein Kinase C/physiology Proto-Oncogenes Pyrimidine Nucleosides/pharmacology Signal Transduction Transcription Factors/physiology Transcription, Genetic
Chemicals
Adenovirus Early Proteins Carrier Proteins Gene Products, tat Oncogene Proteins, Viral Pyrimidine Nucleosides Transcription Factors sangivamycin Cyclic AMP Protein Kinase C 1-Methyl-3-isobutylxanthine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tan T H
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021-6399.
Jia R
Roeder R G
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.63.9.3761-3768.1989
Published
1989-09-00
Pages
3761-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC250968
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.63.9.3761-3768.1989 PMC Full Text View journal details
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