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PMID: 2419836 Published · ppublish English Journal Article

Structural analysis of type II variants within the mouse intracisternal A-particle sequence family.

Nucleic acids research ·Vol. 14 ·No. 3 ·1986-02-11 ·Pages 1495-510

Lueders KK, Mietz JA

Abstract

Intracisternal A-particle (IAP) elements are present in multiple copies in the mouse and other rodent genomes. The bulk of this sequence family in Mus musculus consists of 7 Kb long elements, but the majority of IAP sequences involved in known transpositions have been deleted forms. The present study describes a subset of deleted IAP sequences (type II IAP) characterized by insertion of a particular short sequence element (AIIins). AIIins are interspersed and the majority occur as part of the type II IAP elements in the mouse genome. AIIins sequences are absent or in low copy number outside Mus musculus. We have isolated clones containing AIIins from a mouse genomic DNA library and have sequenced three isolates of AIIins and their surrounding IAP sequences to define the detailed structure of type II elements. AIIins are 272, 268 and 264 bp long and 90% homologous in sequence. They are bracketed by 9 bp duplications, suggesting they may be inserted elements. A 75 bp region containing a core enhancer sequence is repeated at the 5' end in type II IAP elements. Insertion into the IAP genome, with potential to encode an integrase function, may have played a role in the amplification of AIIins.

MeSH Terms
Animals Base Sequence Chromosome Mapping DNA Restriction Enzymes/genetics DNA Transposable Elements Genes, Intracisternal A-Particle Genes, Viral Genetic Linkage Mice/genetics Proto-Oncogenes RNA-Directed DNA Polymerase/genetics Repetitive Sequences, Nucleic Acid
Chemicals
DNA Transposable Elements RNA-Directed DNA Polymerase DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lueders K K
Mietz J A
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/14.3.1495
Published
1986-02-11
Pages
1495-510
Language
English
Region
England
NLM ID
0411011
PMCID
PMC339519
Subset
IM
Databases
GENBANK
X03519, X03520, X03521
External Links
PubMed source DOI: 10.1093/nar/14.3.1495 PMC Full Text View journal details
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