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PMID: 6306589 Published · ppublish English Comparative Study Journal Article

Comparison of the sequence organization of related retrovirus-like multigene families in three evolutionarily distant rodent genomes.

Nucleic acids research ·Vol. 11 ·No. 13 ·1983-07-11 ·Pages 4391-408

Lueders KK, Kuff EL

Abstract

Sequences related to mouse intracisternal A-particle (IAP) genes have been isolated from rat and Syrian hamster gene libraries as recombinants in lambda phage. The sequences are moderately reiterated in both these genomes but their sequence organization in the hamster genome is different from that in the rat genome. Restriction analysis and electron microscopy indicate that the Syrian hamster IAP sequences represent a family of relatively homogeneous well-conserved units; in this, they resemble the mouse IAP genes. The rat sequences, in contrast, are heterogeneous. Both the hamster and rat IAP sequences contain regions homologous to mouse IAP genes interspersed with regions of apparent non-homology. The interspersed regions range in size from 0.5-1.0 kilobases (Kb). The regions of homology among the mouse, rat and Syrian hamster IAP sequences have been mapped to a 5-6 Kb internal region on the mouse IAP genes. Mouse IAP long terminal repeat (LTR) sequences were not detected in the rat and Syrian hamster genomes. We used the thermal stability of hybrids between cloned and genomic IAP sequences to measure family homogeneity. Mouse and Syrian hamster IAP sequences are homogeneous by this criterion, but the rat IAP sequences are heterogeneous with a Tm 6 degrees C below the self-hybrid. The contrasting organization of IAP-related elements in the genomes of these rodents indicates that amplification or homogenization of this sequence family has occurred independently and at different periods of time during their evolution.

MeSH Terms
Animals Base Sequence Biological Evolution Cloning, Molecular Cricetinae Cricetulus/genetics DNA Restriction Enzymes Genes Genes, Viral Mesocricetus/genetics Mice/genetics Microscopy, Electron Nucleic Acid Hybridization Rats/genetics Retroviridae/genetics Rodentia/genetics Species Specificity
Chemicals
DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lueders K K
Kuff E L
References (29)
29 references, click to expand
  1. Prevalence of type R virus-like particles in clones of BHK-21 cells.
    Virology. 1969 Aug;38(4):707-10 PMID: 5803950
  2. Intracisternal A particles in ova and preimplantation stages of the mouse.
    Nat New Biol. 1973 May 16;243(124):91-3 PMID: 4512964
  3. Virus particles in early mouse embryos.
    J Natl Cancer Inst. 1973 Sep;51(3):1041-50 PMID: 4795510
  4. Expression of A- and C-type particles in early mouse embryos.
    J Natl Cancer Inst. 1973 Dec;51(6):1971-5 PMID: 4358153
  5. Two distinct endogenous type C viruses isolated from the asian rodent Mus cervicolor: conservation of virogene sequences in related rodent species.
    J Virol. 1977 Mar;21(3):849-62 PMID: 66330
  6. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
    J Mol Biol. 1977 Jun 15;113(1):237-51 PMID: 881736
  7. Sequences associated with intracisternal A particles are reiterated in the mouse genome.
    Cell. 1977 Dec;12(4):963-72 PMID: 597866
  8. Rat ileocecal immunocytoma. An ultrastructural study with special attention to the presence of viral particles.
    J Natl Cancer Inst. 1978 Aug;61(2):477-84 PMID: 277732
  9. Viruslike particles in hamster embryos, fetuses, and tumors.
    J Natl Cancer Inst. 1978 Sep;61(3):891-5 PMID: 278866
  10. The rat serum albumin gene: analysis of cloned sequences.
    Proc Natl Acad Sci U S A. 1979 Jul;76(7):3256-60 PMID: 158758
  11. Heterogeneity of "virus-like" genes encoding retrovirus-associated 30S RNA and their organization within the mouse genome.
    Cell. 1980 Jun;20(2):431-9 PMID: 6248245
  12. Sequence organization of cloned intracisternal A particle genes.
    Cell. 1980 Sep;21(2):465-73 PMID: 6250723
  13. Intracisternal A-particle genes: identification in the genome of Mus musculus and comparison of multiple isolates from a mouse gene library.
    Proc Natl Acad Sci U S A. 1980 Jun;77(6):3571-5 PMID: 6251469
  14. The baboon endogenous virus genome. II. Provirus sequence variations in baboon cell DNA.
    Nucleic Acids Res. 1980 Oct 10;8(19):4423-40 PMID: 6253918
  15. Structure and organization of the highly repeated and interspersed 1.3 kb EcoRI-Bg1II sequence family in mice.
    Nucleic Acids Res. 1980 Nov 11;8(21):5031-42 PMID: 6255440
  16. Terminally redundant sequences in cellular intracisternal A-particle genes.
    J Virol. 1981 May;38(2):680-7 PMID: 7241664
  17. Early mouse embryo intracisternal particle: Fourth type of retrovirus-like particle associated with the mouse.
    J Natl Cancer Inst. 1981 Sep;67(3):677-85 PMID: 6944537
  18. Sequences homologous to retrovirus-like genes of the mouse are present in multiple copies in the Syrian hamster genome.
    Nucleic Acids Res. 1981 Nov 25;9(22):5917-30 PMID: 7198224
  19. Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes.
    J Mol Biol. 1981 Aug 25;150(4):441-66 PMID: 6276556
  20. Form and function of retroviral proviruses.
    Science. 1982 May 21;216(4548):812-20 PMID: 6177038
  21. Patterns of genomic distribution and sequence heterogeneity of a murine "retrovirus-like" multigene family.
    J Virol. 1982 Jul;43(1):50-8 PMID: 6287016
  22. Evidence for an early evolutionary origin and locus polymorphism of mouse VL30 DNA sequences.
    J Virol. 1982 Aug;43(2):511-8 PMID: 7109032
  23. Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element.
    Nature. 1982 Dec 16;300(5893):607-11 PMID: 6292737
  24. Molecular cloning of retrovirus-like genes present in multiple copies in the Syrian hamster genome.
    Nucleic Acids Res. 1982 Oct 11;10(19):5733-46 PMID: 6292848
  25. Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.
    Proc Natl Acad Sci U S A. 1982 Dec;79(23):7425-9 PMID: 6296832
  26. Characterization and partial nucleotide sequence of endogenous type C retrovirus segments in human chromosomal DNA.
    Proc Natl Acad Sci U S A. 1983 Feb;80(3):678-82 PMID: 6298769
  27. Homology between an endogenous viral LTR and sequences inserted in an activated cellular oncogene.
    Nature. 1983 Apr 7;302(5908):547-8 PMID: 6835385
  28. Intracisternal A-particle genes as movable elements in the mouse genome.
    Proc Natl Acad Sci U S A. 1983 Apr;80(7):1992-6 PMID: 6300886
  29. Intracisternal A-particle genes in Mus musculus: a conserved family of retrovirus-like elements.
    Mol Cell Biol. 1981 Mar;1(3):216-27 PMID: 6821514
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/11.13.4391
Published
1983-07-11
Pages
4391-408
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326054
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/11.13.4391 PMC Full Text View journal details
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