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PMID: 7109032 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Evidence for an early evolutionary origin and locus polymorphism of mouse VL30 DNA sequences.

Journal of virology ·Vol. 43 ·No. 2 ·1982-08-00 ·Pages 511-8

Courtney MG, Elder PK, Steffen DL, Getz MJ

Abstract

The VL30 sequences of mouse DNA are a family of sequences with retrovirus-like structure which code for a 30S RNA transcript that can be packaged into the virions of murine leukemia viruses and thereby transmitted from cell to cell. A Southern blot analysis of these sequences revealed that multiple copies are present in the DNA of all mice examined, regardless of species or geographic origin. Considerable locus polymorphism was also apparent, and at least one of these polymorphisms appeared to reflect the differing chromosomal location of a complete VL30 sequence. These data indicated that VL30 elements are not recent additions to the mouse genome and suggested that the evolution of the VL30 multigene family has been accompanied by duplication and dispersion of VL30 sequences to diverse genomic sites. In addition, we reexamined the issue of genetic relatedness between mouse VL30 sequences and a physically similar family of virus-like elements in the rat genome. We found that many, if not all, rat and mouse VL30 loci contain regions of sequence homology. These data suggested that rodent VL30 sequences have evolved from a common ancestral sequence.

MeSH Terms
Animals Base Sequence Biological Evolution Chromosome Mapping Chromosomes DNA, Viral Genes, Viral Mice/genetics,microbiology Mice, Inbred Strains/microbiology Muridae/genetics,microbiology Nucleic Acid Hybridization Polymorphism, Genetic Retroviridae/genetics Species Specificity
Chemicals
DNA, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Courtney M G
Elder P K
Steffen D L
Getz M J
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30 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.43.2.511-518.1982
Published
1982-08-00
Pages
511-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256154
Subset
IM
Grants
NIGMS NIH HHS · GM 25510 · United States
External Links
PubMed source DOI: 10.1128/JVI.43.2.511-518.1982 PMC Full Text View journal details
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