Identification of a 30S RNA with properties of a defective type C virus in murine cells.

Journal of virology ·Vol. 25 ·No. 1 ·1978-01-00 ·Pages 115-23

Howk RS, Troxler DH, Lowy D, Duesberg PH, Scolnick EM

Abstract

A novel species of 30S RNA has been detected in a variety of mouse cell lines. The 30S RNA is specifically packaged by helper-independent type C viruses propagated in such cells. Nucleic acid hybridization detects no homology between the 30SRNA and the genomic RNA of helper-independent mouse type C viruses. The properties of the 30S RNA suggest that it is a defective endogenous mouse type C virus and that it is analogous to a previously described class of defective endogenous rat type C virus, which has been shown previously to be the progenitor of Kirsten and Harvey murine sarcoma viruses.

MeSH Terms

Animals Cell Line Defective Viruses/analysis Gammaretrovirus/analysis Mice Mice, Inbred Strains Nucleic Acid Conformation Nucleic Acid Hybridization RNA, Viral/analysis Retroviridae/analysis Transcription, Genetic

Chemicals

RNA, Viral

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Howk R S

Troxler D H

Lowy D

Duesberg P H

Scolnick E M

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29 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.25.1.115-123.1978

Published

1978-01-00

Pages

115-23

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC353907

Subset

External Links

PubMed source DOI: 10.1128/JVI.25.1.115-123.1978 PMC Full Text View journal details

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Identification of a 30S RNA with properties of a defective type C virus in murine cells.

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