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PMID: 23175120 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Medulloblastomics: the end of the beginning.

Nature reviews. Cancer ·Vol. 12 ·No. 12 ·2012-12-00 ·Pages 818-34

Northcott PA, Jones DT, Kool M, Robinson GW, Gilbertson RJ, Cho YJ, Pomeroy SL, Korshunov A, Lichter P, Taylor MD, Pfister SM

Abstract

The division of medulloblastoma into different subgroups by microarray expression profiling has dramatically changed our perspective of this malignant childhood brain tumour. Now, the availability of next-generation sequencing and complementary high-density genomic technologies has unmasked novel driver mutations in each medulloblastoma subgroup. The implications of these findings for the management of patients are readily apparent, pinpointing previously unappreciated diagnostic and therapeutic targets. In this Review, we summarize the 'explosion' of data emerging from the application of modern genomics to medulloblastoma, and in particular the recurrent targets of mutation in medulloblastoma subgroups. These data are currently making their way into clinical trials as we seek to integrate conventional and molecularly targeted therapies.

MeSH Terms
Animals Cerebellar Neoplasms/genetics,metabolism Child Cyclin-Dependent Kinase 6/genetics DNA Mutational Analysis Female Genome-Wide Association Study Genomics/methods Hedgehog Proteins/genetics,metabolism Histones/metabolism Humans Male Medulloblastoma/genetics,metabolism Mice Mutation Signal Transduction Tetraploidy beta Catenin/genetics
Chemicals
CTNNB1 protein, human Hedgehog Proteins Histones SHH protein, human beta Catenin CDK6 protein, human Cyclin-Dependent Kinase 6
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Northcott Paul A
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Jones David T W
Kool Marcel
Robinson Giles W
Gilbertson Richard J
Cho Yoon-Jae
Pomeroy Scott L
Korshunov Andrey
Lichter Peter
Taylor Michael D
Pfister Stefan M
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc3410
Published
2012-12-00
Pages
818-34
Language
English
Region
England
NLM ID
101124168
PMCID
PMC3889646
Subset
IM
Grants
NCI NIH HHS · R01 CA129541 · United States
NCI NIH HHS · R01CA159859 · United States
NCI NIH HHS · R01 CA159859 · United States
NICHD NIH HHS · P30 HD018655 · United States
NCI NIH HHS · R01 CA109467 · United States
NCI NIH HHS · R01 CA148699 · United States
NCI NIH HHS · R01CA148699 · United States
NCI NIH HHS · P01 CA096832 · United States
External Links
PubMed source DOI: 10.1038/nrc3410 PMC Full Text View journal details
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