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PMID: 21614026 Published · epublish English Journal Article Research Support, N.I.H., Extramural Review

The Hedgehog's tale: developing strategies for targeting cancer.

Nature reviews. Cancer ·Vol. 11 ·No. 7 ·2011-05-26 ·Pages 493-501

Ng JM, Curran T

Abstract

Research into basic developmental biology has frequently yielded insights into cancer biology. This is particularly true for the Hedgehog (HH) pathway. Activating mutations in the HH pathway cause a subset of sporadic and familial, skin (basal cell carcinoma) and brain (medulloblastoma) tumours. Furthermore, the growth of many human tumours is supported by HH pathway activity in stromal cells. Naturally occurring and synthetic inhibitors of HH signalling show great promise in animal models and in early clinical studies. However, it remains unclear how many cancers will ultimately benefit from these new, molecularly targeted therapies.

MeSH Terms
Animals Clinical Trials as Topic Hedgehog Proteins/antagonists & inhibitors,genetics,physiology Humans Medulloblastoma/genetics Mutation Neoplasms/drug therapy,etiology,genetics Receptors, G-Protein-Coupled/antagonists & inhibitors Rhabdomyosarcoma/genetics Signal Transduction/physiology Smoothened Receptor
Chemicals
Hedgehog Proteins Receptors, G-Protein-Coupled SMO protein, human Smoothened Receptor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ng Jessica M Y
Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 4060 Colket Translational Research Building, 3501 Civic Center Boulevard, Philadelphia PA 19104, USA. ngj@email.chop.edu
Curran Tom
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc3079
Email
ngj@email.chop.edu
Published
2011-05-26
Epub
2011-00-26
Pages
493-501
Language
English
Region
England
NLM ID
101124168
PMCID
PMC3576812
Subset
IM
Grants
NCI NIH HHS · P01 CA096832 · United States
NCI NIH HHS · CA096832 · United States
External Links
PubMed source DOI: 10.1038/nrc3079 PMC Full Text View journal details
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