Mouse models and mouse supermodels.

EMBO molecular medicine ·Vol. 2 ·No. 10 ·2010-10-00 ·Pages 385-6; author reply 386-7

Curran T

Abstract

暂无摘要

MeSH Terms

Animals Antineoplastic Agents/administration & dosage Carcinoma/drug therapy,pathology Colonic Neoplasms/drug therapy,pathology Cyclodextrins/administration & dosage Disease Models, Animal Drug Therapy/methods Humans Mice Veratrum Alkaloids/administration & dosage

Chemicals

Antineoplastic Agents Cyclodextrins Veratrum Alkaloids cyclopamine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Curran Tom

References (11)

11 references, click to expand

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
N Engl J Med. 2009 Sep 17;361(12):1173-8 PMID: 19726761
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Cancer Cell. 2004 Sep;6(3):229-40 PMID: 15380514
Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies.
Cancer Res. 2006 Apr 15;66(8):4215-22 PMID: 16618744
Targeting the Hedgehog pathway in cancer.
Nat Rev Drug Discov. 2006 Dec;5(12):1026-33 PMID: 17139287
A paracrine requirement for hedgehog signalling in cancer.
Nature. 2008 Sep 18;455(7211):406-10 PMID: 18754008
Hedgehog signalling in colon cancer and stem cells.
EMBO Mol Med. 2009 Sep;1(6-7):300-2 PMID: 20049733
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.
N Engl J Med. 2009 Sep 17;361(12):1164-72 PMID: 19726763
Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.
Cancer Cell. 2008 Mar;13(3):249-60 PMID: 18328428
Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion.
EMBO Mol Med. 2009 Sep;1(6-7):338-51 PMID: 20049737
The Hedgehog response network: sensors, switches, and routers.
Science. 2004 Jun 18;304(5678):1755-9 PMID: 15205520
The pediatric preclinical testing program: description of models and early testing results.
Pediatr Blood Cancer. 2007 Dec;49(7):928-40 PMID: 17066459

Article Info

Journal

EMBO molecular medicine

Abbr.

EMBO Mol Med

ISSN

1757-4684

DOI

10.1002/emmm.201000090

Published

2010-10-00

Pages

385-6; author reply 386-7

Language

English

Region

England

NLM ID

101487380

PMCID

PMC3377340

Subset

Grants

NCI NIH HHS · P01 CA096832 · United States

NCI NIH HHS · P01 CA096832-03 · United States

Corrections

CommentOn

PMID: 20049733

CommentOn

PMID: 20049737

External Links

PubMed source DOI: 10.1002/emmm.201000090 PMC Full Text View journal details

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