Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.

Administration, Oral Aging/metabolism Animals Animals, Newborn Antineoplastic Agents/administration & dosage,toxicity Bone Remodeling/drug effects Bone and Bones/drug effects,embryology,metabolism,pathology Calcification, Physiologic/drug effects Cell Differentiation/drug effects Cell Proliferation/drug effects Cells, Cultured Cerebellar Neoplasms/drug therapy Chondrocytes/drug effects,metabolism,pathology Dose-Response Relationship, Drug Growth Plate/drug effects,pathology Hedgehog Proteins/metabolism Kruppel-Like Transcription Factors/genetics,metabolism Luciferases/genetics,metabolism Medulloblastoma/drug therapy Mice Mice, Transgenic Microscopy, Fluorescence Microscopy, Video Osteogenesis/drug effects Receptors, G-Protein-Coupled/antagonists & inhibitors,metabolism Recombinant Fusion Proteins/metabolism Signal Transduction/drug effects Smoothened Receptor Time Factors Zinc Finger Protein GLI1

Antineoplastic Agents Gli1 protein, mouse Hedgehog Proteins Kruppel-Like Transcription Factors Receptors, G-Protein-Coupled Recombinant Fusion Proteins Smo protein, mouse Smoothened Receptor Zinc Finger Protein GLI1 Luciferases