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PMID: 21560073 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles.

Cellular and molecular life sciences : CMLS ·Vol. 68 ·No. 16 ·2011-08-00 ·Pages 2667-88

György B, Szabó TG, Pásztói M, Pál Z, Misják P, Aradi B, László V, Pállinger E, Pap E, Kittel A, Nagy G, Falus A, Buzás EI

Abstract

Release of membrane vesicles, a process conserved in both prokaryotes and eukaryotes, represents an evolutionary link, and suggests essential functions of a dynamic extracellular vesicular compartment (including exosomes, microparticles or microvesicles and apoptotic bodies). Compelling evidence supports the significance of this compartment in a broad range of physiological and pathological processes. However, classification of membrane vesicles, protocols of their isolation and detection, molecular details of vesicular release, clearance and biological functions are still under intense investigation. Here, we give a comprehensive overview of extracellular vesicles. After discussing the technical pitfalls and potential artifacts of the rapidly emerging field, we compare results from meta-analyses of published proteomic studies on membrane vesicles. We also summarize clinical implications of membrane vesicles. Lessons from this compartment challenge current paradigms concerning the mechanisms of intercellular communication and immune regulation. Furthermore, its clinical implementation may open new perspectives in translational medicine both in diagnostics and therapy.

MeSH Terms
Autoimmune Diseases/diagnosis,metabolism Biomarkers/metabolism Cell-Derived Microparticles/chemistry,metabolism,physiology Exosomes/chemistry,metabolism,physiology Humans Neoplasms/diagnosis,metabolism Particle Size Proteome/metabolism
Chemicals
Biomarkers Proteome
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
György Bence
Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Nagyvárad tér, Hungary.
Szabó Tamás G
Pásztói Mária
Pál Zsuzsanna
Misják Petra
Aradi Borbála
László Valéria
Pállinger Eva
Pap Erna
Kittel Agnes
Nagy György
Falus András
Buzás Edit I
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Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-9071
DOI
10.1007/s00018-011-0689-3
Published
2011-08-00
Epub
2011-00-11
Pages
2667-88
Language
English
Region
Switzerland
NLM ID
9705402
PMCID
PMC3142546
Subset
IM
External Links
PubMed source DOI: 10.1007/s00018-011-0689-3 PMC Full Text View journal details
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