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PMID: 18396047 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Itinerant exosomes: emerging roles in cell and tissue polarity.

Trends in cell biology ·Vol. 18 ·No. 5 ·2008-05-00 ·Pages 199-209

Lakkaraju A, Rodriguez-Boulan E

Abstract

Cells use secreted signals (e.g. chemokines and growth factors) and sophisticated vehicles such as argosomes, cytonemes, tunneling nanotubes and exosomes to relay important information to other cells, often over large distances. Exosomes, 30-100-nm intraluminal vesicles of multivesicular bodies (MVB) released upon exocytic fusion of the MVB with the plasma membrane, are increasingly recognized as a novel mode of cell-independent communication. Exosomes have been shown to function in antigen presentation and tumor metastasis, and in transmitting infectious agents. However, little is known about the biogenesis and function of exosomes in polarized cells. In this review, we discuss new evidence suggesting that exosomes participate in the transport of morphogens and RNA, and thus influence cell polarity and developmental patterning of tissues.

MeSH Terms
Animals Antigen Presentation Cell Communication Cell Lineage Cell Membrane/metabolism Cellular Structures/metabolism Cytoplasmic Vesicles/metabolism Endocytosis Endosomes/metabolism Golgi Apparatus/metabolism Humans Membrane Microdomains Models, Biological Neoplasm Metastasis RNA/metabolism
Chemicals
RNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lakkaraju Aparna
Margaret M. Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA. apl2001@med.cornell.edu
Rodriguez-Boulan Enrique
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Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
1879-3088
DOI
10.1016/j.tcb.2008.03.002
Email
apl2001@med.cornell.edu
Published
2008-05-00
Epub
2008-00-07
Pages
199-209
Language
English
Region
England
NLM ID
9200566
PMCID
PMC3754907
Subset
IM
Grants
NEI NIH HHS · R01 EY008538 · United States
NIGMS NIH HHS · R01 GM034107 · United States
NEI NIH HHS · EY08538 · United States
NIGMS NIH HHS · GM34107 · United States
External Links
PubMed source DOI: 10.1016/j.tcb.2008.03.002 PMC Full Text View journal details
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