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PMID: 17506697 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Biogenesis and function of multivesicular bodies.

Annual review of cell and developmental biology ·Vol. 23 ·2007-00-00 ·Pages 519-47

Piper RC, Katzmann DJ

Abstract

The two major cellular sites for membrane protein degradation are the proteasome and the lysosome. Ubiquitin attachment is a sorting signal for both degradation routes. For lysosomal degradation, ubiquitination triggers the sorting of cargo proteins into the lumen of late endosomal multivesicular bodies (MVBs)/endosomes. MVB formation occurs when a portion of the limiting membrane of an endosome invaginates and buds into its own lumen. Intralumenal vesicles are degraded when MVBs fuse to lysosomes. The proper delivery of proteins to the MVB interior relies on specific ubiquitination of cargo, recognition and sorting of ubiquitinated cargo to endosomal subdomains, and the formation and scission of cargo-filled intralumenal vesicles. Over the past five years, a number of proteins that may directly participate in these aspects of MVB function and biogenesis have been identified. However, major questions remain as to exactly what these proteins do at the molecular level and how they may accomplish these tasks.

MeSH Terms
Animals Endosomes/metabolism Humans Lipid Metabolism Lysosomes/metabolism Protein Conformation Protein Sorting Signals Protein Transport Proteins/chemistry,metabolism Ubiquitin/metabolism Ubiquitination
Chemicals
Protein Sorting Signals Proteins Ubiquitin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Piper Robert C
Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA. robert-piper@uiowa.edu
Katzmann David J
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Article Info
Journal
Annual review of cell and developmental biology
Abbr.
Annu Rev Cell Dev Biol
ISSN
1081-0706
DOI
10.1146/annurev.cellbio.23.090506.123319
Email
robert-piper@uiowa.edu
Published
2007-00-00
Pages
519-47
Language
English
Region
United States
NLM ID
9600627
PMCID
PMC2911632
Subset
IM
Grants
NIGMS NIH HHS · R01 GM058202-09 · United States
NIGMS NIH HHS · R01 GM 58202 · United States
NIGMS NIH HHS · R01 GM 73024 · United States
NIGMS NIH HHS · R01 GM073024 · United States
NIGMS NIH HHS · R01 GM058202 · United States
External Links
PubMed source DOI: 10.1146/annurev.cellbio.23.090506.123319 PMC Full Text View journal details
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