Receptor downregulation and multivesicular-body sorting.

Nature reviews. Molecular cell biology ·Vol. 3 ·No. 12 ·2002-12-00 ·Pages 893-905

Katzmann DJ, Odorizzi G, Emr SD

Abstract

The sorting of proteins into the inner vesicles of multivesicular bodies is required for many key cellular processes, which range from the downregulation of activated signalling receptors to the proper stimulation of the immune response. Recent advances in our understanding of the multivesicular-body sorting pathway have resulted from the identification of ubiquitin as a signal for the efficient sorting of proteins into this transport route, and from the discovery of components of the sorting and regulatory machinery that directs this complex process.

MeSH Terms

Animals Carrier Proteins/metabolism Cytoplasmic Vesicles/metabolism Down-Regulation/physiology Endosomal Sorting Complexes Required for Transport Endosomes/metabolism Epidermal Growth Factor/metabolism Humans Membrane Proteins/metabolism Models, Biological Phospholipids/metabolism Protein Structure, Tertiary Protein Transport/physiology Receptors, Cell Surface/metabolism Receptors, Notch Saccharomyces cerevisiae Proteins Signal Transduction/physiology Ubiquitin/metabolism Vesicular Transport Proteins Yeasts/metabolism,ultrastructure

Chemicals

Carrier Proteins Endosomal Sorting Complexes Required for Transport Membrane Proteins Phospholipids Receptors, Cell Surface Receptors, Notch STP22 protein, S cerevisiae Saccharomyces cerevisiae Proteins Ubiquitin Vesicular Transport Proteins Epidermal Growth Factor

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Katzmann David J

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA. katzmann.david@mayo.edu

Odorizzi Greg

Emr Scott D

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/nrm973

katzmann.david@mayo.edu

Published

2002-12-00

Pages

893-905

Language

English

Region

England

NLM ID

100962782

Subset

External Links

PubMed source DOI: 10.1038/nrm973 View journal details

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Receptor downregulation and multivesicular-body sorting.

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