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PMID: 21116305 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Small RNA sorting: matchmaking for Argonautes.

Nature reviews. Genetics ·Vol. 12 ·No. 1 ·2011-01-00 ·Pages 19-31

Czech B, Hannon GJ

Abstract

Small RNAs directly or indirectly impact nearly every biological process in eukaryotic cells. To perform their myriad roles, not only must precise small RNA species be generated, but they must also be loaded into specific effector complexes called RNA-induced silencing complexes (RISCs). Argonaute proteins form the core of RISCs and different members of this large family have specific expression patterns, protein binding partners and biochemical capabilities. In this Review, we explore the mechanisms that pair specific small RNA strands with their partner proteins, with an eye towards the substantial progress that has been recently made in understanding the sorting of the major small RNA classes - microRNAs (miRNAs) and small interfering RNAs (siRNAs) - in plants and animals.

MeSH Terms
Animals Diptera/metabolism Eukaryotic Initiation Factors/metabolism Humans MicroRNAs/metabolism Plants/metabolism RNA Transport RNA, Double-Stranded/metabolism RNA, Small Interfering/metabolism RNA-Induced Silencing Complex/metabolism
Chemicals
Eukaryotic Initiation Factors MicroRNAs RNA, Double-Stranded RNA, Small Interfering RNA-Induced Silencing Complex
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Czech Benjamin
Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
Hannon Gregory J
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2916
Published
2011-01-00
Epub
2010-00-30
Pages
19-31
Language
English
Region
England
NLM ID
100962779
PMCID
PMC3703915
Subset
IM
Grants
NIGMS NIH HHS · R01 GM062534 · United States
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1038/nrg2916 PMC Full Text View journal details
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