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PMID: 20066116 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Membrane organization and dynamics in cell polarity.

Cold Spring Harbor perspectives in biology ·Vol. 1 ·No. 5 ·2009-11-00 ·Pages a001321

Orlando K, Guo W

Abstract

The establishment and maintenance of cell polarity is important to a wide range of biological processes ranging from chemotaxis to embryogenesis. An essential feature of cell polarity is the asymmetric organization of proteins and lipids in the plasma membrane. In this article, we discuss how polarity regulators such as small GTP-binding proteins and phospholipids spatially and kinetically control vesicular trafficking and membrane organization. Conversely, we discuss how membrane trafficking contributes to cell polarization through delivery of polarity determinants and regulators to the plasma membrane.

MeSH Terms
Animals Cadherins/metabolism Cell Membrane/metabolism Cell Polarity Chemotaxis Dictyostelium/metabolism Drosophila melanogaster Exocytosis Kinetics Lipids/chemistry Models, Biological cdc42 GTP-Binding Protein/metabolism rab GTP-Binding Proteins/metabolism rho GTP-Binding Proteins/metabolism
Chemicals
Cadherins Lipids cdc42 GTP-Binding Protein rab GTP-Binding Proteins rho GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Orlando Kelly
Department of Biology, University of Pennsylvania, Philadelphia, 19104-6018, USA.
Guo Wei
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Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a001321
Published
2009-11-00
Pages
a001321
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC2773647
Subset
IM
Grants
NIGMS NIH HHS · R01 GM064690 · United States
NIGMS NIH HHS · R01 GM085146 · United States
External Links
PubMed source DOI: 10.1101/cshperspect.a001321 PMC Full Text View journal details
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