Exocytosis: the many masters of the exocyst.

Current biology : CB ·Vol. 12 ·No. 6 ·2002-03-19 ·Pages R212-4

Lipschutz JH, Mostov KE

Abstract

The exocyst is a conserved eight-subunit complex involved in the docking of exocytic vesicles. The exocyst has now been identified as an effector for five small GTPases, including Sec4, Rho1, Rho3, Cdc42 and, most recently, RalA.

MeSH Terms

Animals Exocytosis/physiology Fungal Proteins GTP Phosphohydrolases/metabolism Humans Mammals Saccharomyces cerevisiae Proteins Vesicular Transport Proteins Yeasts cdc42 GTP-Binding Protein rab GTP-Binding Proteins/metabolism ral GTP-Binding Proteins rho GTP-Binding Proteins/metabolism

Chemicals

EXO70 protein, S cerevisiae Fungal Proteins SEC5 protein, S cerevisiae Saccharomyces cerevisiae Proteins Vesicular Transport Proteins GTP Phosphohydrolases RALA protein, human SEC4 protein, S cerevisiae RHO3 protein, S cerevisiae cdc42 GTP-Binding Protein rab GTP-Binding Proteins ral GTP-Binding Proteins rho GTP-Binding Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lipschutz Joshua H

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. jhlipsch@mail.med.upenn.edu

Mostov Keith E

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(02)00753-4

jhlipsch@mail.med.upenn.edu

Published

2002-03-19

Pages

R212-4

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(02)00753-4 View journal details

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Exocytosis: the many masters of the exocyst.

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