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PMID: 20023718 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Global signatures of protein and mRNA expression levels.

Molecular bioSystems ·Vol. 5 ·No. 12 ·2009-12-00 ·Pages 1512-26

de Sousa Abreu R, Penalva LO, Marcotte EM, Vogel C

Abstract

Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.

MeSH Terms
Computational Biology/methods Escherichia coli/genetics,metabolism Humans Protein Biosynthesis Proteins/genetics,metabolism RNA, Messenger/biosynthesis,genetics Ubiquitination Yeasts/genetics,metabolism
Chemicals
Proteins RNA, Messenger
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
de Sousa Abreu Raquel
Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, TX, USA.
Penalva Luiz O
Marcotte Edward M
Vogel Christine
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Article Info
Journal
Molecular bioSystems
Abbr.
Mol Biosyst
ISSN
1742-2051
DOI
10.1039/b908315d
Published
2009-12-00
Epub
2009-00-01
Pages
1512-26
Language
English
Region
England
NLM ID
101251620
PMCID
PMC4089977
Subset
IM
Grants
NIGMS NIH HHS · R01 GM076536 · United States
External Links
PubMed source DOI: 10.1039/b908315d PMC Full Text
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