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PMID: 12097249 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions.

Clinical microbiology reviews ·Vol. 15 ·No. 3 ·2002-07-00 ·Pages 414-29

Caamaño J, Hunter CA

Abstract

Transcription factors of the Rel/NF-kappaB family are activated in response to signals that lead to cell growth, differentiation, and apoptosis, and these proteins are critical elements involved in the regulation of immune responses. The conservation of this family of transcription factors in many phyla and their association with antimicrobial responses indicate their central role in the regulation of innate immunity. This is illustrated by the association of homologues of NF-kappaB, and their regulatory proteins, with resistance to infection in insects and plants (M. S. Dushay, B. Asling, and D. Hultmark, Proc. Natl. Acad. Sci. USA 93:10343-10347, 1996; D. Hultmark, Trends Genet. 9:178-183, 1993; J. Ryals et al., Plant Cell 9:425-439, 1997). The aim of this review is to provide a background on the biology of NF-kappaB and to highlight areas of the innate and adaptive immune response in which these transcription factors have a key regulatory function and to review what is currently known about their roles in resistance to infection, the host-pathogen interaction, and development of human disease.

MeSH Terms
Animals B-Lymphocytes/immunology Humans Immunity, Innate Infections/etiology,immunology Mice NF-kappa B/metabolism Signal Transduction T-Lymphocytes/immunology
Chemicals
NF-kappa B
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Caamaño Jorge
Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6008, USA.
Hunter Christopher A
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Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.15.3.414-429.2002
Published
2002-07-00
Pages
414-29
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC118079
Subset
IM
Grants
PHS HHS · NIH 41158 · United States
PHS HHS · NIH 46288 · United States
External Links
PubMed source DOI: 10.1128/CMR.15.3.414-429.2002 PMC Full Text View journal details
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