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PMID: 10556817 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Expression of Th2 cytokines and the stable Th2 marker ST2L in the absence of IL-4 during Leishmania major infection.

European journal of immunology ·Vol. 29 ·No. 11 ·1999-00-00 ·Pages 3621-8

Kropf P, Schopf LR, Chung CL, Xu D, Liew FY, Sypek JP, Müller I

Abstract

In this study we characterized Th2 responses in the absence of IL-4. We show that ST2L, a stable Th2 marker, is expressed at similar levels in Leishmania major-infected IL-4-deficient (IL-4(-/-)) and wild-type BALB/c (IL-4(+/+)) mice. Th2 cytokines are secreted by in vivo differentiated lymphocytes in response to specific activation in the absence of IL-4. Although IL-13 is produced, its neutralization did not alter the outcome of infection. Thus, we demonstrate that Th2 differentiation as assessed by the expression of ST2L and the production of Th2 cytokines can occur in vivo in the absence of IL-4.

MeSH Terms

Animals Antibodies, Monoclonal Cricetinae Cytokines/biosynthesis Disease Models, Animal Interleukin-1 Receptor-Like 1 Protein Interleukin-10/biosynthesis Interleukin-13/biosynthesis Interleukin-4/immunology Interleukin-5/biosynthesis Interleukin-6/biosynthesis Leishmania major/immunology Leishmaniasis, Cutaneous/immunology Membrane Proteins Mice Mice, Inbred BALB C Mice, Knockout Neutralization Tests Protein Biosynthesis Receptors, Interleukin Th2 Cells/immunology

Chemicals

Antibodies, Monoclonal Cytokines Il1rl1 protein, mouse Interleukin-1 Receptor-Like 1 Protein Interleukin-13 Interleukin-5 Interleukin-6 Membrane Proteins Receptors, Interleukin Interleukin-10 Interleukin-4

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Kropf P

Imperial College School of Medicine, St. Mary's Department of Immunology, London, GB.

Schopf L R

Chung C L

Xu D

Liew F Y

Sypek J P

Müller I

Article Info

Journal

European journal of immunology

Abbr.

Eur J Immunol

ISSN

0014-2980

DOI

10.1002/(SICI)1521-4141(199911)29:11<3621::AID-IMMU3621>3.0.CO;2-Z

Published

1999-00-00

Pages

3621-8

Language

English

Region

Germany

NLM ID

1273201

Subset

Grants

Wellcome Trust · United Kingdom

External Links

PubMed source DOI: 10.1002/(SICI)1521-4141(199911)29:11<3621::AID-IMMU3621>3.0.CO;2-Z View journal details

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Expression of Th2 cytokines and the stable Th2 marker ST2L in the absence of IL-4 during Leishmania major infection.

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