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PMID: 10426996 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.

Science (New York, N.Y.) ·Vol. 285 ·No. 5428 ·1999-07-30 ·Pages 736-9

Aliprantis AO, Yang RB, Mark MR, Suggett S, Devaux B, Radolf JD, Klimpel GR, Godowski P, Zychlinsky A

Abstract

Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial pathogens. All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2). BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2. In addition, BLPs stimulated nuclear factor-kappaB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2. Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms.

MeSH Terms

Antibodies, Monoclonal Apoptosis Bacterial Proteins/metabolism,pharmacology Cell Line/metabolism Cycloheximide/pharmacology Cytotoxicity, Immunologic Drosophila Proteins Genes, Reporter Humans Lipopolysaccharide Receptors/analysis Lipopolysaccharides/immunology Lipoproteins/metabolism,pharmacology Membrane Glycoproteins/immunology,metabolism Monocytes/cytology,immunology,metabolism NF-kappa B/metabolism Protein Synthesis Inhibitors/pharmacology Reactive Oxygen Species/metabolism Receptors, Cell Surface/immunology,metabolism Signal Transduction Tetradecanoylphorbol Acetate/pharmacology Toll-Like Receptor 2 Toll-Like Receptors Transfection Tumor Cells, Cultured

Chemicals

Antibodies, Monoclonal Bacterial Proteins Drosophila Proteins Lipopolysaccharide Receptors Lipopolysaccharides Lipoproteins Membrane Glycoproteins NF-kappa B Protein Synthesis Inhibitors Reactive Oxygen Species Receptors, Cell Surface TLR2 protein, human Toll-Like Receptor 2 Toll-Like Receptors Cycloheximide Tetradecanoylphorbol Acetate

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Aliprantis A O

Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

Yang R B

Mark M R

Suggett S

Devaux B

Radolf J D

Klimpel G R

Godowski P

Zychlinsky A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.285.5428.736

Published

1999-07-30

Pages

736-9

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAID NIH HHS · AI 37720-04 · United States

NIAID NIH HHS · AI-38894 · United States

External Links

PubMed source DOI: 10.1126/science.285.5428.736 View journal details

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Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.

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