Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Animals Antigens, Bacterial/immunology Cell Wall/immunology Corynebacterium diphtheriae/chemistry,immunology Drosophila Proteins Escherichia coli/chemistry,immunology Female Gram-Negative Bacteria/chemistry,immunology Gram-Positive Bacteria/chemistry,immunology Interleukin-1 Receptor-Associated Kinases Lipid A/immunology Lipopolysaccharides/immunology Macrophages, Peritoneal/immunology Male Membrane Glycoproteins/deficiency,genetics,physiology Mice Mice, Inbred C57BL Mice, Knockout NF-kappa B/metabolism Nocardia/chemistry,immunology Peptidoglycan/immunology Protein Isoforms/deficiency,genetics,physiology Protein Kinases/metabolism Receptors, Cell Surface/deficiency,genetics,physiology Salmonella/chemistry,immunology Signal Transduction Species Specificity Staphylococcus aureus/chemistry,immunology Teichoic Acids/immunology Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors

Antigens, Bacterial Drosophila Proteins Lipid A Lipopolysaccharides Membrane Glycoproteins NF-kappa B Peptidoglycan Protein Isoforms Receptors, Cell Surface Teichoic Acids Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors lipoteichoic acid Protein Kinases Interleukin-1 Receptor-Associated Kinases