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PMID: 20023663 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Shiga toxins--from cell biology to biomedical applications.

Nature reviews. Microbiology ·Vol. 8 ·No. 2 ·2010-02-00 ·Pages 105-16

Johannes L, Römer W

Abstract

Shiga toxin-producing Escherichia coli is an emergent pathogen that can induce haemolytic uraemic syndrome. The toxin has received considerable attention not only from microbiologists but also in the field of cell biology, where it has become a powerful tool to study intracellular trafficking. In this Review, we summarize the Shiga toxin family members and their structures, receptors, trafficking pathways and cellular targets. We discuss how Shiga toxin affects cells not only by inhibiting protein biosynthesis but also through the induction of signalling cascades that lead to apoptosis. Finally, we discuss how Shiga toxins might be exploited in cancer therapy and immunotherapy.

MeSH Terms
Animals Antigens, Tumor-Associated, Carbohydrate/metabolism Apoptosis Cell Membrane/drug effects Humans Immunotherapy Neoplasms/therapy Shiga Toxins/chemistry,metabolism,pharmacology,therapeutic use Shiga-Toxigenic Escherichia coli/metabolism,pathogenicity Signal Transduction
Chemicals
Antigens, Tumor-Associated, Carbohydrate Gb3 antigen Shiga Toxins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Johannes Ludger
Institut Curie - Centre de Recherche and CNRS UMR144, Traffic, Signalling and Delivery Laboratory, 26 rue d'Ulm, 75248 Paris Cedex 05, France. ludger.johannes@curie.fr
Römer Winfried
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Article Info
Journal
Nature reviews. Microbiology
Abbr.
Nat Rev Microbiol
ISSN
1740-1534
DOI
10.1038/nrmicro2279
Email
ludger.johannes@curie.fr
Published
2010-02-00
Epub
2009-00-21
Pages
105-16
Language
English
Region
England
NLM ID
101190261
Subset
IM
External Links
PubMed source DOI: 10.1038/nrmicro2279 View journal details
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