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PMID: 2001714 Published · ppublish English Comparative Study Journal Article Review

mRNA processing in the Trypanosomatidae.

Experientia ·Vol. 47 ·No. 2 ·1991-02-15 ·Pages 118-28

Perry K, Agabian N

Abstract

Members of the Trypanosomatidae, which include the African trypanosomes, the American trypanosomes and the leishmanias, cause disease in vast proportions in man and his livestock and are a major detrimental factor to the social and economic well-being of the third world. Current research using the techniques of molecular biology has revealed two unusual types of mRNA processing in these protozoans; these are the addition of a shared leader sequence to the 5' ends of nuclear mRNAs by a mechanism of trans splicing, and the insertion and deletion of specific uridine residues in mitochondrial transcripts by RNA editing. The presence of these two mRNA processing pathways in the Trypanosomatidae has profound consequences for the organization and expression of their genetic information.

Related Genes
MURF2
MeSH Terms
Amino Acid Sequence Animals Base Sequence Caenorhabditis/genetics Cell Nucleus/metabolism DNA, Mitochondrial/genetics Leishmania/genetics Mitochondria/physiology Molecular Sequence Data RNA Processing, Post-Transcriptional RNA Splicing RNA, Messenger/genetics RNA, Small Nuclear/genetics Sequence Homology, Nucleic Acid Trypanosoma/genetics
Chemicals
DNA, Mitochondrial RNA, Messenger RNA, Small Nuclear
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Perry K
Intercampus Program, Molecular Parasitology, University of California, San Francisco.
Agabian N
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71 references, click to expand
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01945412
Published
1991-02-15
Pages
118-28
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01945412
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