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PMID: 6090933 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes.

Nature ·Vol. 311 ·No. 5984 ·1984-00-00 ·Pages 350-5

Campbell DA, Thornton DA, Boothroyd JC

Abstract

The repeated mini-exon sequence that encodes the first 35 base pairs of all variant surface antigen mRNAs of Trypanosoma brucei directs the synthesis of a discrete 137-nucleotide transcript. It thus seems that variant surface antigen mRNAs are transcribed discontinuously, and we present two alternative models for how this might occur.

MeSH Terms
Animals Base Sequence Cloning, Molecular DNA Restriction Enzymes Genes Glycoproteins/genetics Models, Genetic Transcription, Genetic Trypanosoma brucei brucei/genetics Variant Surface Glycoproteins, Trypanosoma
Chemicals
Glycoproteins Variant Surface Glycoproteins, Trypanosoma DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Campbell D A
Thornton D A
Boothroyd J C
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41 references, click to expand
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/311350a0
Published
1984-00-00
Pages
350-5
Language
English
Region
England
NLM ID
0410462
PMCID
PMC7095118
Subset
IM
Databases
GENBANK
X00935
External Links
PubMed source DOI: 10.1038/311350a0 PMC Full Text View journal details
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