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PMID: 19841742 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice.

PloS one ·Vol. 4 ·No. 10 ·2009-10-20 ·Pages e7506

Gobeske KT, Das S, Bonaguidi MA, Weiss C, Radulovic J, Disterhoft JF, Kessler JA

Abstract

Exposure to exercise or to environmental enrichment increases the generation of new neurons in the adult hippocampus and promotes certain kinds of learning and memory. While the precise role of neurogenesis in cognition has been debated intensely, comparatively few studies have addressed the mechanisms linking environmental exposures to cellular and behavioral outcomes. Here we show that bone morphogenetic protein (BMP) signaling mediates the effects of exercise on neurogenesis and cognition in the adult hippocampus. Elective exercise reduces levels of hippocampal BMP signaling before and during its promotion of neurogenesis and learning. Transgenic mice with decreased BMP signaling or wild type mice infused with a BMP inhibitor both exhibit remarkable gains in hippocampal cognitive performance and neurogenesis, mirroring the effects of exercise. Conversely, transgenic mice with increased BMP signaling have diminished hippocampal neurogenesis and impaired cognition. Exercise exposure does not rescue these deficits, suggesting that reduced BMP signaling is required for environmental effects on neurogenesis and learning. Together, these observations show that BMP signaling is a fundamental mechanism linking environmental exposure with changes in cognitive function and cellular properties in the hippocampus.

MeSH Terms
Animals Behavior, Animal Bone Morphogenetic Protein 4/metabolism Cell Proliferation Cognition Female Hippocampus/metabolism Male Maze Learning Mice Mice, Inbred C57BL Neurons/metabolism Physical Conditioning, Animal Signal Transduction Transgenes
Chemicals
Bmp4 protein, mouse Bone Morphogenetic Protein 4
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Gobeske Kevin T
Department of Neurology, Northwestern University's Feinberg School of Medicine, Chicago, Illinois, United States of America.
Das Sunit
Bonaguidi Michael A
Weiss Craig
Radulovic Jelena
Disterhoft John F
Kessler John A
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Article Info
Journal
PloS one
Abbr.
PLoS One
ISSN
1932-6203
DOI
10.1371/journal.pone.0007506
Published
2009-10-20
Epub
2009-00-20
Pages
e7506
Language
English
Region
United States
NLM ID
101285081
PMCID
PMC2759555
Subset
IM
Grants
NINDS NIH HHS · R01 NS020778-26 · United States
NIA NIH HHS · R01 AG017139 · United States
NINDS NIH HHS · R01 NS020013-26 · United States
NIMH NIH HHS · R01 MH078064 · United States
NIMH NIH HHS · R01 MH047340 · United States
NINDS NIH HHS · R01 NS020778 · United States
NIA NIH HHS · R37 AG008796 · United States
NINDS NIH HHS · R01 NS020013 · United States
External Links
PubMed source DOI: 10.1371/journal.pone.0007506 PMC Full Text View journal details
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