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PMID: 17113656 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning.

Behavioural brain research ·Vol. 176 ·No. 2 ·2007-01-25 ·Pages 362-6

O'Callaghan RM, Ohle R, Kelly AM

Abstract

Physical activity may have the potential to improve cognitive function. Here we show that forced treadmill-running results in selective improvements in hippocampal plasticity. Rats that underwent exercise training demonstrated enhanced expression of long-term potentiation in dentate gyrus and enhanced object recognition learning. Spatial learning in the Morris watermaze was unaffected by exercise. These changes were associated with an increase in expression of brain-derived neurotrophic factor in the dentate gyrus.

MeSH Terms

Analysis of Variance Animals Behavior, Animal Brain-Derived Neurotrophic Factor/metabolism Electric Stimulation/methods Escape Reaction/physiology Exercise Test Hippocampus/cytology Learning/physiology Long-Term Potentiation/physiology,radiation effects Male Maze Learning/physiology Neuronal Plasticity/physiology Physical Conditioning, Animal/methods Rats Rats, Wistar Reaction Time/physiology Spatial Behavior/physiology

Chemicals

Brain-Derived Neurotrophic Factor

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

O'Callaghan Rachel M

Department of Physiology, School of Medicine, University of Dublin, Trinity College, Dublin 2, Ireland.

Ohle Robert

Kelly Aine M

Article Info

Journal

Behavioural brain research

Abbr.

Behav Brain Res

ISSN

0166-4328

DOI

10.1016/j.bbr.2006.10.018

Published

2007-01-25

Epub

2006-00-20

Pages

362-6

Language

English

Region

Netherlands

NLM ID

8004872

Subset

External Links

PubMed source DOI: 10.1016/j.bbr.2006.10.018 View journal details

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The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning.

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