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PMID: 14999064 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 24 ·No. 9 ·2004-03-03 ·Pages 2133-42

Chmielnicki E, Benraiss A, Economides AN, Goldman SA

Abstract

Neurogenesis from endogenous progenitor cells in the adult forebrain ventricular wall may be induced by the local viral overexpression of cognate neuronal differentiation agents, in particular BDNF. Here, we show that the overexpression of noggin, by acting to inhibit glial differentiation by subependymal progenitor cells, can potentiate adenoviral BDNF-mediated recruitment of new neurons to the adult rat neostriatum. The new neurons survive at least 2 months after their genesis in the subependymal zone and are recruited primarily as GABAergic DARPP-32+ medium spiny neurons in the caudate-putamen. The new medium spiny neurons successfully project to the globus pallidus, their usual developmental target, extending processes over several millimeters of the normal adult striatum. Thus, concurrent suppression of subependymal glial differentiation and promotion of neuronal differentiation can mobilize endogenous subependymal progenitor cells to achieve substantial neuronal addition to otherwise non-neurogenic regions of the adult brain.

MeSH Terms
Adenoviridae/genetics Animals Bone Morphogenetic Proteins/biosynthesis,genetics,pharmacology Brain-Derived Neurotrophic Factor/biosynthesis,genetics,pharmacology Bromodeoxyuridine Carrier Proteins Cell Differentiation/drug effects,genetics Fluorescent Dyes Gene Transfer Techniques Genetic Vectors/administration & dosage,genetics Globus Pallidus/cytology Humans Lateral Ventricles/cytology,drug effects Neostriatum/cytology,drug effects Neuroglia/cytology,drug effects Neurons/cytology,drug effects,metabolism Rats Rats, Sprague-Dawley Stem Cells/cytology,drug effects,metabolism Stilbamidines
Chemicals
2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt Bone Morphogenetic Proteins Brain-Derived Neurotrophic Factor Carrier Proteins Fluorescent Dyes Stilbamidines noggin protein Bromodeoxyuridine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chmielnicki Eva
Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA.
Benraiss Abdellatif
Economides Aris N
Goldman Steven A
References (37)
37 references, click to expand
  1. Adult mammalian forebrain ependymal and subependymal cells demonstrate proliferative potential, but only subependymal cells have neural stem cell characteristics.
    J Neurosci. 1999 Jun 1;19(11):4462-71 PMID: 10341247
  2. Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro.
    J Neurosci. 1999 Jul 1;19(13):5409-19 PMID: 10377350
  3. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.
    Cell. 1999 Jun 11;97(6):703-16 PMID: 10380923
  4. Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma.
    Mol Cell Neurosci. 1999 Jun;13(6):450-64 PMID: 10383830
  5. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons.
    Neuron. 1999 Jun;23(2):257-71 PMID: 10399933
  6. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS.
    J Neurosci. 1999 Oct 1;19(19):8487-97 PMID: 10493749
  7. Induction of neurogenesis in the neocortex of adult mice.
    Nature. 2000 Jun 22;405(6789):951-5 PMID: 10879536
  8. Noggin antagonizes BMP signaling to create a niche for adult neurogenesis.
    Neuron. 2000 Dec;28(3):713-26 PMID: 11163261
  9. Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain.
    J Neurosci. 2001 Sep 1;21(17):6718-31 PMID: 11517261
  10. Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients.
    J Biol Chem. 2002 Jan 18;277(3):2089-96 PMID: 11706034
  11. Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain.
    Neuron. 2002 Jun 13;34(6):945-60 PMID: 12086642
  12. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain.
    Nat Med. 2003 Apr;9(4):439-47 PMID: 12627226
  13. Postmitotic death is the fate of constitutively proliferating cells in the subependymal layer of the adult mouse brain.
    J Neurosci. 1992 Jan;12(1):249-56 PMID: 1729437
  14. Manipulation of adenovirus vectors.
    Methods Mol Biol. 1991;7:109-28 PMID: 21416352
  15. Posttranslational modification of class III beta-tubulin.
    Proc Natl Acad Sci U S A. 1990 Sep;87(18):7195-9 PMID: 2402501
  16. Embryonic vertebrate central nervous system: revised terminology. The Boulder Committee.
    Anat Rec. 1970 Feb;166(2):257-61 PMID: 5414696
  17. Cytokines regulate the cellular phenotype of developing neural lineage species.
    Int J Dev Neurosci. 1995 Jun-Jul;13(3-4):213-40 PMID: 7572277
  18. BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronal precursors.
    J Neurosci. 1995 Aug;15(8):5765-78 PMID: 7643217
  19. Identification of mammalian noggin and its expression in the adult nervous system.
    J Neurosci. 1995 Sep;15(9):6077-84 PMID: 7666191
  20. Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone.
    Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):210-4 PMID: 7816819
  21. bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells.
    Neuron. 1993 Nov;11(5):951-66 PMID: 8240816
  22. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors.
    Nat Genet. 1993 Mar;3(3):229-34 PMID: 8485578
  23. Alternative forms of rat TrkC with different functional capabilities.
    Neuron. 1993 May;10(5):963-74 PMID: 8494647
  24. FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain.
    Mol Cell Neurosci. 1995 Oct;6(5):474-86 PMID: 8581317
  25. The division of neuronal progenitor cells during migration in the neonatal mammalian forebrain.
    Mol Cell Neurosci. 1995 Dec;6(6):496-508 PMID: 8742267
  26. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.
    Cell. 1996 Aug 23;86(4):599-606 PMID: 8752214
  27. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4.
    Eur J Neurosci. 1996 Jul;8(7):1452-60 PMID: 8758952
  28. In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain.
    J Neurosci. 1996 Apr 15;16(8):2649-58 PMID: 8786441
  29. Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells.
    Neuron. 1996 Oct;17(4):595-606 PMID: 8893018
  30. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain.
    J Neurosci. 1997 Jul 1;17(13):5046-61 PMID: 9185542
  31. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain.
    J Neurosci. 1997 Aug 1;17(15):5820-9 PMID: 9221780
  32. Gliogenesis in postnatal rat optic nerve: LC1 + microglia and S100-beta + astrocytes.
    Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):27-36 PMID: 9263577
  33. Birth, migration, incorporation, and death of vocal control neurons in adult songbirds.
    J Neurobiol. 1997 Nov;33(5):585-601 PMID: 9369461
  34. Strategies utilized by migrating neurons of the postnatal vertebrate forebrain.
    Trends Neurosci. 1998 Mar;21(3):107-14 PMID: 9530917
  35. Fibroblast growth factor-2/brain-derived neurotrophic factor-associated maturation of new neurons generated from adult human subependymal cells.
    Ann Neurol. 1998 May;43(5):576-85 PMID: 9585351
  36. Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb.
    Mol Cell Neurosci. 1998 Jul;11(4):234-45 PMID: 9675054
  37. Adult neurogenesis: from canaries to the clinic.
    J Neurobiol. 1998 Aug;36(2):267-86 PMID: 9712309
Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.1554-03.2004
Published
2004-03-03
Pages
2133-42
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6730416
Subset
IM
External Links
PubMed source DOI: 10.1523/JNEUROSCI.1554-03.2004 PMC Full Text View journal details
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