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PMID: 14709544 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes.

The Journal of cell biology ·Vol. 164 ·No. 1 ·2004-01-05 ·Pages 111-22

Hsieh J, Aimone JB, Kaspar BK, Kuwabara T, Nakashima K, Gage FH

Abstract

Adult multipotent neural progenitor cells can differentiate into neurons, astrocytes, and oligodendrocytes in the mammalian central nervous system, but the molecular mechanisms that control their differentiation are not yet well understood. Insulin-like growth factor I (IGF-I) can promote the differentiation of cells already committed to an oligodendroglial lineage during development. However, it is unclear whether IGF-I affects multipotent neural progenitor cells. Here, we show that IGF-I stimulates the differentiation of multipotent adult rat hippocampus-derived neural progenitor cells into oligodendrocytes. Modeling analysis indicates that the actions of IGF-I are instructive. Oligodendrocyte differentiation by IGF-I appears to be mediated through an inhibition of bone morphogenetic protein signaling. Furthermore, overexpression of IGF-I in the hippocampus leads to an increase in oligodendrocyte markers. These data demonstrate the existence of a single molecule, IGF-I, that can influence the fate choice of multipotent adult neural progenitor cells to an oligodendroglial lineage.

MeSH Terms
Animals Biomarkers Bone Morphogenetic Proteins/metabolism Cell Differentiation/drug effects,physiology Cell Lineage/drug effects,physiology Cells, Cultured Feedback, Physiological/physiology Female Hippocampus/cytology,embryology,metabolism Insulin-Like Growth Factor I/genetics,metabolism,pharmacology Multipotent Stem Cells/cytology,drug effects,metabolism Neurons/cytology,metabolism Oligodendroglia/cytology,metabolism Rats Rats, Inbred F344 Signal Transduction/physiology Stem Cells/cytology,drug effects,metabolism Up-Regulation/drug effects,genetics
Chemicals
Biomarkers Bone Morphogenetic Proteins Insulin-Like Growth Factor I
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Hsieh Jenny
Laboratory of Genetics, The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Aimone James B
Kaspar Brian K
Kuwabara Tomoko
Nakashima Kinichi
Gage Fred H
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200308101
Published
2004-01-05
Pages
111-22
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2171962
Subset
IM
Grants
NIA NIH HHS · R01 AG020938 · United States
NIA NIH HHS · AG 020938 · United States
External Links
PubMed source DOI: 10.1083/jcb.200308101 PMC Full Text View journal details
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