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PMID: 17108182 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 26 ·No. 46 ·2006-11-15 ·Pages 12089-99

Bauer S, Patterson PH

Abstract

Although neural stem cells (NSCs) persist in various areas of the adult brain, their contribution to brain repair after injury is very limited. Treatment with exogenous growth factors can mitigate this limitation, suggesting that the brain environment is normally deficient in permissive cues and that it may be possible to stimulate the latent regenerative potential of endogenous progenitors with appropriate signals. We analyzed the effects of overexpressing the cytokine leukemia inhibitory factor (LIF) on adult neurogenesis in the normal brain. We found that LIF reduces neurogenesis in the olfactory bulb and subventricular zone by acting directly on NSCs. LIF appears to promote NSC self-renewal, preventing the emergence of more differentiated cell types. This ultimately leads to an expansion of the NSC pool. Our results have implications for the development of therapeutic strategies for brain repair and suggest that LIF may be useful, in combination with other factors, in promoting regeneration in the adult brain.

MeSH Terms
Adenoviridae/genetics Animals Antimitotic Agents/pharmacology Bromodeoxyuridine Cell Differentiation/drug effects,physiology Cell Proliferation/drug effects Cells, Cultured Genetic Vectors/physiology Injections, Intraventricular Leukemia Inhibitory Factor/genetics,pharmacology,physiology Male Mice Mice, Inbred C57BL Nerve Growth Factors/pharmacology Nerve Regeneration/drug effects,physiology Neuroglia/cytology,drug effects,metabolism Neuronal Plasticity/drug effects,physiology Neurons/cytology,drug effects,metabolism Spheroids, Cellular Stem Cells/cytology,drug effects,metabolism Telencephalon/cytology,drug effects,metabolism Transfection/methods
Chemicals
Antimitotic Agents Leukemia Inhibitory Factor Nerve Growth Factors Bromodeoxyuridine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bauer Sylvian
Biology Division, California Institute of Technology, Pasadena, California 91125, USA.
Patterson Paul H
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.3047-06.2006
Published
2006-11-15
Pages
12089-99
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6674883
Subset
IM
External Links
PubMed source DOI: 10.1523/JNEUROSCI.3047-06.2006 PMC Full Text View journal details
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