Home LiteratureArticle Details
PMID: 12629177 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 23 ·No. 5 ·2003-03-01 ·Pages 1730-41

Chojnacki A, Shimazaki T, Gregg C, Weinmaster G, Weiss S

Abstract

Glycoprotein130 (gp130) and Notch signaling are thought to participate in neural stem cell (NSC) self-renewal. We asked whether gp130 regulates Notch activity in forebrain epidermal growth factor (EGF)-responsive NSCs. Disruption of Notch1 using antisense or a gamma-secretase inhibitor demonstrated a requirement for Notch1 in the maintenance and proliferation of NSCs. Ciliary neurotrophic factor (CNTF) activation of gp130 in NSCs rapidly increased Notch1 expression. NOTCH1 activation, indicated by tumor necrosis factor alpha-converting enzyme (TACE)- and presenilin-mediated processing, also increased. Infusion of EGF+CNTF into adult forebrain lateral ventricles increased periventricular NOTCH1 compared with EGF alone. Neither Hes1 (hairy and enhancer of split) nor Hes5 appeared to mediate gp130-enhanced NOTCH1 signaling that regulates NSC maintenance. This is the first example of a link between gp130 signaling and NOTCH1 in regulating NSC self-renewal.

MeSH Terms
Amyloid Precursor Protein Secretases Animals Antigens, CD/metabolism Aspartic Acid Endopeptidases Cell Communication/physiology Cells, Cultured Ciliary Neurotrophic Factor/pharmacology Cytokine Receptor gp130 Endopeptidases/drug effects Enzyme Inhibitors/pharmacology Epidermal Growth Factor/pharmacology Gene Expression Regulation, Developmental/drug effects,physiology Leukemia Inhibitory Factor Receptor alpha Subunit Membrane Glycoproteins/metabolism Membrane Proteins/antagonists & inhibitors,genetics,metabolism Mice Mice, Knockout Neurons/cytology,drug effects,metabolism Prosencephalon/cytology,embryology RNA, Messenger/metabolism Receptor, Ciliary Neurotrophic Factor/metabolism Receptor, Notch1 Receptors, Cell Surface Receptors, Cytokine/deficiency,genetics,metabolism Receptors, OSM-LIF Signal Transduction/drug effects,physiology Stem Cells/cytology,drug effects,metabolism Transcription Factors
Chemicals
Antigens, CD Ciliary Neurotrophic Factor Enzyme Inhibitors Il6st protein, mouse Leukemia Inhibitory Factor Receptor alpha Subunit Lifr protein, mouse Membrane Glycoproteins Membrane Proteins Notch1 protein, mouse RNA, Messenger Receptor, Ciliary Neurotrophic Factor Receptor, Notch1 Receptors, Cell Surface Receptors, Cytokine Receptors, OSM-LIF Transcription Factors Cytokine Receptor gp130 Epidermal Growth Factor Amyloid Precursor Protein Secretases Endopeptidases Aspartic Acid Endopeptidases Bace1 protein, mouse
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Chojnacki Andrew
Genes & Development Research Group, Department of Cell Biology and Anatomy, University of Calgary, Faculty of Medicine, Calgary, Alberta, Canada T2N 4N1.
Shimazaki Takuya
Gregg Christopher
Weinmaster Gerry
Weiss Samuel
References (51)
51 references, click to expand
  1. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
    Biochemistry. 1999 Apr 13;38(15):4720-7 PMID: 10200159
  2. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
    Nature. 1999 Apr 8;398(6727):518-22 PMID: 10206645
  3. Notch signaling: cell fate control and signal integration in development.
    Science. 1999 Apr 30;284(5415):770-6 PMID: 10221902
  4. Functional roles of STAT family proteins: lessons from knockout mice.
    Stem Cells. 1999;17(3):138-46 PMID: 10342556
  5. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.
    Cell. 1999 Jun 11;97(6):703-16 PMID: 10380923
  6. In vitro expansion of a multipotent population of human neural progenitor cells.
    Exp Neurol. 1999 Aug;158(2):265-78 PMID: 10415135
  7. The Notch-Hes pathway in mammalian neural development.
    Cell Res. 1999 Sep;9(3):179-88 PMID: 10520600
  8. Nuclear Notch1 signaling and the regulation of dendritic development.
    Nat Neurosci. 2000 Jan;3(1):30-40 PMID: 10607392
  9. The bHLH gene hes1 as a repressor of the neuronal commitment of CNS stem cells.
    J Neurosci. 2000 Jan 1;20(1):283-93 PMID: 10627606
  10. Mammalian neural stem cells.
    Science. 2000 Feb 25;287(5457):1433-8 PMID: 10688783
  11. Cytokines that signal through the leukemia inhibitory factor receptor-beta complex in the nervous system.
    J Neurochem. 2000 Mar;74(3):889-99 PMID: 10693919
  12. Transcriptional regulation of the Drosophila raf proto-oncogene by Drosophila STAT during development and in immune response.
    J Biol Chem. 2000 Jun 30;275(26):19824-30 PMID: 10764759
  13. Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium.
    Development. 2000 Jun;127(11):2323-32 PMID: 10804175
  14. Presenilin-1 regulates neuronal differentiation during neurogenesis.
    Development. 2000 Jun;127(12):2593-606 PMID: 10821758
  15. Negative autoregulation of Mash1 expression in CNS development.
    Dev Biol. 2000 Jun 15;222(2):336-46 PMID: 10837123
  16. rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells.
    Neuron. 2000 May;26(2):383-94 PMID: 10839357
  17. Radial glial identity is promoted by Notch1 signaling in the murine forebrain.
    Neuron. 2000 May;26(2):395-404 PMID: 10839358
  18. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells.
    Cell. 2000 May 26;101(5):499-510 PMID: 10850492
  19. The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation.
    Development. 2000 Jul;127(13):2933-43 PMID: 10851137
  20. Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation.
    Development. 2000 Jul;127(14):2989-98 PMID: 10862737
  21. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.
    Mol Cell. 2000 Feb;5(2):197-206 PMID: 10882062
  22. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.
    Mol Cell. 2000 Feb;5(2):207-16 PMID: 10882063
  23. The subventricular zone: source of neuronal precursors for brain repair.
    Prog Brain Res. 2000;127:1-11 PMID: 11142024
  24. Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors.
    Development. 2001 Mar;128(5):689-702 PMID: 11171394
  25. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm.
    Genes Cells. 2001 Feb;6(2):175-85 PMID: 11260262
  26. A unified hypothesis on the lineage of neural stem cells.
    Nat Rev Neurosci. 2001 Apr;2(4):287-93 PMID: 11283751
  27. Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain.
    J Biol Chem. 2001 Aug 10;276(32):30467-74 PMID: 11399758
  28. Interactions between fibroblast growth factors and Notch regulate neuronal differentiation.
    J Neurosci. 2001 Aug 1;21(15):5587-96 PMID: 11466430
  29. The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells.
    J Neurosci. 2001 Oct 1;21(19):7642-53 PMID: 11567054
  30. Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.
    Genes Dev. 2002 Apr 1;16(7):846-58 PMID: 11937492
  31. The Role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse exo utero system.
    J Neurosci. 2002 Jul 1;22(13):5516-24 PMID: 12097503
  32. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes.
    J Neurosci. 1992 Nov;12(11):4565-74 PMID: 1432110
  33. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.
    Science. 1992 Mar 27;255(5052):1707-10 PMID: 1553558
  34. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells.
    Nature. 1988 Dec 15;336(6200):684-7 PMID: 3143916
  35. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides.
    Nature. 1988 Dec 15;336(6200):688-90 PMID: 3143917
  36. Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells.
    Neuron. 1994 Nov;13(5):1071-82 PMID: 7946346
  37. Long-distance neuronal migration in the adult mammalian brain.
    Science. 1994 May 20;264(5162):1145-8 PMID: 8178174
  38. Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells.
    Development. 1993 Nov;119(3):559-65 PMID: 8187629
  39. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch.
    Development. 1995 Nov;121(11):3637-50 PMID: 8582277
  40. Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell.
    Dev Biol. 1996 Apr 10;175(1):1-13 PMID: 8608856
  41. Network of tangential pathways for neuronal migration in adult mammalian brain.
    Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14895-900 PMID: 8962152
  42. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway.
    Development. 1996 Dec;122(12):3765-73 PMID: 9012498
  43. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.
    Proc Natl Acad Sci U S A. 1997 May 13;94(10):5355-60 PMID: 9144241
  44. Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma.
    J Neurosci. 1997 Oct 15;17(20):7850-9 PMID: 9315905
  45. Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements.
    Development. 1997 Nov;124(21):4265-73 PMID: 9334275
  46. Dominant enhancers of Egfr in Drosophila melanogaster: genetic links between the Notch and Egfr signaling pathways.
    Genetics. 1997 Nov;147(3):1139-53 PMID: 9383058
  47. Notch inhibition of E47 supports the existence of a novel signaling pathway.
    Mol Cell Biol. 1998 Apr;18(4):2230-9 PMID: 9528794
  48. The Notch1 receptor is cleaved constitutively by a furin-like convertase.
    Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8108-12 PMID: 9653148
  49. Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system.
    Development. 1999 Feb;126(3):443-56 PMID: 9876174
  50. Mash1 regulates neurogenesis in the ventral telencephalon.
    Development. 1999 Feb;126(3):525-34 PMID: 9876181
  51. A role for the POU-III transcription factor Brn-4 in the regulation of striatal neuron precursor differentiation.
    EMBO J. 1999 Jan 15;18(2):444-56 PMID: 9889200
Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
Published
2003-03-01
Pages
1730-41
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6741977
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2