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PMID: 19664273 Published · epublish English Journal Article

Regulation of MicroRNA Biogenesis: A miRiad of mechanisms.

Cell communication and signaling : CCS ·Vol. 7 ·2009-08-10 ·Pages 18

Davis BN, Hata A

Abstract

microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses. Widespread use of microRNA arrays to profile microRNA expression has indicated that the levels of many microRNAs are altered during development and disease. These findings have prompted a great deal of investigation into the mechanism and function of microRNA-mediated repression. However, the mechanisms which govern the regulation of microRNA biogenesis and activity are just beginning to be uncovered. Following transcription, mature microRNA are generated through a series of coordinated processing events mediated by large protein complexes. It is increasingly clear that microRNA biogenesis does not proceed in a 'one-size-fits-all' manner. Rather, individual classes of microRNAs are differentially regulated through the association of regulatory factors with the core microRNA biogenesis machinery. Here, we review the regulation of microRNA biogenesis and activity, with particular focus on mechanisms of post-transcriptional control. Further understanding of the regulation of microRNA biogenesis and activity will undoubtedly provide important insights into normal development as well as pathological conditions such as cardiovascular disease and cancer.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Davis Brandi N
Department of Biochemistry, Tufts University School of Medicine, Boston MA 02111, USA. brandi.davis@tufts.edu.
Hata Akiko
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Article Info
Journal
Cell communication and signaling : CCS
Abbr.
Cell Commun Signal
ISSN
1478-811X
DOI
10.1186/1478-811X-7-18
Email
brandi.davis@tufts.edu
Published
2009-08-10
Epub
2009-00-10
Pages
18
Language
English
Region
England
NLM ID
101170464
PMCID
PMC3224893
External Links
PubMed source DOI: 10.1186/1478-811X-7-18 PMC Full Text View journal details
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