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PMID: 19644920 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Genomic mutation rates: what high-throughput methods can tell us.

BioEssays : news and reviews in molecular, cellular and developmental biology ·Vol. 31 ·No. 9 ·2009-09-00 ·Pages 912-20

Nishant KT, Singh ND, Alani E

Abstract

High-throughput DNA analyses are increasingly being used to detect rare mutations in moderately sized genomes. These methods have yielded genome mutation rates that are markedly higher than those obtained using pre-genomic strategies. Recent work in a variety of organisms has shown that mutation rate is strongly affected by sequence context and genome position. These observations suggest that high-throughput DNA analyses will ultimately allow researchers to identify trans-acting factors and cis sequences that underlie mutation rate variation. Such work should provide insights on how mutation rate variability can impact genome organization and disease progression.

MeSH Terms
Animals Disease Progression Evolution, Molecular Genome Humans Mutation Sequence Analysis, DNA/methods
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Nishant Koodali T
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853-2703, USA.
Singh Nadia D
Alani Eric
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Article Info
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
Abbr.
Bioessays
ISSN
1521-1878
DOI
10.1002/bies.200900017
Published
2009-09-00
Pages
912-20
Language
English
Region
United States
NLM ID
8510851
PMCID
PMC2952423
Subset
IM
Grants
NIGMS NIH HHS · F32 GM080944 · United States
NIGMS NIH HHS · R01 GM053085-15 · United States
NIGMS NIH HHS · R01 GM053085 · United States
NIGMS NIH HHS · GM53085 · United States
NIGMS NIH HHS · 1F32GM080944-01 · United States
External Links
PubMed source DOI: 10.1002/bies.200900017 PMC Full Text View journal details
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