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PMID: 15286780 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Cancer genes and the pathways they control.

Nature medicine ·Vol. 10 ·No. 8 ·2004-08-00 ·Pages 789-99

Vogelstein B, Kinzler KW

Abstract

The revolution in cancer research can be summed up in a single sentence: cancer is, in essence, a genetic disease. In the last decade, many important genes responsible for the genesis of various cancers have been discovered, their mutations precisely identified, and the pathways through which they act characterized. The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation.

MeSH Terms
Adenomatous Polyposis Coli Protein/metabolism Apoptosis/genetics,physiology DNA Repair/genetics,physiology DNA-Binding Proteins/metabolism Genes, Tumor Suppressor/physiology Humans Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Mutation/genetics Neoplasms/genetics,metabolism Nuclear Proteins/metabolism Oncogenes/genetics,physiology Phosphatidylinositol 3-Kinases/metabolism Receptor Protein-Tyrosine Kinases/metabolism Retinoblastoma Protein/metabolism Signal Transduction/genetics,physiology Smad Proteins Trans-Activators/metabolism Transcription Factors/metabolism Tumor Suppressor Protein p53/metabolism Zinc Finger Protein GLI1
Chemicals
Adenomatous Polyposis Coli Protein DNA-Binding Proteins GLI1 protein, human HIF1A protein, human Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Nuclear Proteins Retinoblastoma Protein Smad Proteins Trans-Activators Transcription Factors Tumor Suppressor Protein p53 Zinc Finger Protein GLI1 Phosphatidylinositol 3-Kinases Receptor Protein-Tyrosine Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Vogelstein Bert
Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA. vogelbe@welch.jhu.edu
Kinzler Kenneth W
Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1078-8956
DOI
10.1038/nm1087
Email
vogelbe@welch.jhu.edu
Published
2004-08-00
Pages
789-99
Language
English
Region
United States
NLM ID
9502015
Subset
IM
Grants
NCI NIH HHS · CA43460 · United States
NCI NIH HHS · CA57345 · United States
NCI NIH HHS · CA62924 · United States
External Links
PubMed source DOI: 10.1038/nm1087 View journal details
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