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PMID: 19496745 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Regulation of Ca2+ signaling with particular focus on mast cells.

Critical reviews in immunology ·Vol. 29 ·No. 2 ·2009-00-00 ·Pages 155-86

Ma HT, Beaven MA

Abstract

Calcium signals mediate diverse cellular functions in immunological cells. Early studies with mast cells, then a preeminent model for studying Ca2+-dependent exocytosis, revealed several basic features of calcium signaling in non-electrically excitable cells. Subsequent studies in these and other cells further defined the basic processes such as inositol 1,4,5-trisphosphate-mediated release of Ca2+ from Ca2+ stores in the endoplasmic reticulum (ER); coupling of ER store depletion to influx of external Ca2+ through a calcium-release activated calcium (CRAC) channel now attributed to the interaction of the ER Ca2+ sensor, stromal interacting molecule-1 (STIM1), with a unique Ca2+-channel protein, Orai1/CRACM1, and subsequent uptake of excess Ca2+ into ER and mitochondria through ATP-dependent Ca2+ pumps. In addition, transient receptor potential channels and ion exchangers also contribute to the generation of calcium signals that may be global or have dynamic (e.g., waves and oscillations) and spatial resolution for specific functional readouts. This review discusses past and recent developments in this field of research, the pharmacologic agents that have assisted in these endeavors, and the mast cell as an exemplar for sorting out how calcium signals may regulate multiple outputs in a single cell.

MeSH Terms
Animals Calcium/immunology,metabolism Calcium Channels/immunology,metabolism Calcium Signaling/physiology Calcium-Transporting ATPases/immunology,metabolism Humans Inositol 1,4,5-Trisphosphate Receptors/immunology,metabolism Mast Cells/immunology,metabolism Membrane Potentials/physiology Membrane Proteins/immunology,metabolism Mitochondria/immunology,metabolism Signal Transduction/physiology TRPC Cation Channels/immunology,metabolism
Chemicals
Calcium Channels Inositol 1,4,5-Trisphosphate Receptors Membrane Proteins TRPC Cation Channels Calcium-Transporting ATPases Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ma Hong-Tao
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Beaven Michael A
References (321)
321 references, click to expand
  1. Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.
    J Biol Chem. 1991 Sep 15;266(26):17067-71 PMID: 1832668
  2. Roles of CRAC and Cav-like channels in T cells: more than one gatekeeper?
    Trends Pharmacol Sci. 2006 Jul;27(7):360-7 PMID: 16766050
  3. The action of lanthanum and manganese on anaphylactic histamine secretion.
    Br J Pharmacol. 1973 Jul;48(3):527-37 PMID: 4128659
  4. Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell line.
    Pflugers Arch. 1995 Apr;429(6):809-19 PMID: 7603835
  5. Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect.
    Br J Pharmacol. 2005 Jun;145(4):405-14 PMID: 15806115
  6. The mitochondrial calcium uniporter is a highly selective ion channel.
    Nature. 2004 Jan 22;427(6972):360-4 PMID: 14737170
  7. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.
    J Cell Biol. 2008 Jun 30;181(7):1107-16 PMID: 18591429
  8. Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor.
    Neuron. 1997 Sep;19(3):723-33 PMID: 9331361
  9. Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.
    Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70 PMID: 2138778
  10. Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.
    J Biol Chem. 2007 Oct 5;282(40):29448-56 PMID: 17702753
  11. Calcium flickers steer cell migration.
    Nature. 2009 Feb 12;457(7231):901-5 PMID: 19118385
  12. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons.
    J Biol Chem. 2000 Jun 16;275(24):18195-200 PMID: 10764737
  13. Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB).
    Br J Pharmacol. 2008 Mar;153(6):1324-30 PMID: 18204483
  14. Assessment of the role of the inositol 1,4,5-trisphosphate receptor in the activation of transient receptor potential channels and store-operated Ca2+ entry channels.
    J Biol Chem. 2001 Jun 1;276(22):18888-96 PMID: 11259416
  15. Microtubule disruption suppresses allergic response through the inhibition of calcium influx in the mast cell degranulation pathway.
    J Immunol. 2005 Apr 15;174(8):4584-9 PMID: 15814680
  16. Calcium signaling in lymphocytes.
    Curr Opin Immunol. 2008 Jun;20(3):250-8 PMID: 18515054
  17. Plasticity of mitochondrial calcium signaling.
    J Biol Chem. 2003 Oct 24;278(43):42273-82 PMID: 12907683
  18. Synthesis and Ca2+-mobilizing activity of purine-modified mimics of adenophostin A: a model for the adenophostin-Ins(1,4,5)P3 receptor interaction.
    J Med Chem. 2003 Nov 6;46(23):4860-71 PMID: 14584937
  19. Functional stoichiometry of the unitary calcium-release-activated calcium channel.
    Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13668-73 PMID: 18757751
  20. The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors.
    J Biol Chem. 2006 Mar 17;281(11):6970-6 PMID: 16410239
  21. A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity.
    Mol Pharmacol. 2006 Apr;69(4):1413-20 PMID: 16407466
  22. Presenilin-mediated signal transduction.
    Physiol Behav. 2007 Sep 10;92(1-2):93-7 PMID: 17568632
  23. Interaction of cyclopiazonic acid with rat skeletal muscle sarcoplasmic reticulum vesicles. Effect on Ca2+ binding and Ca2+ permeability.
    Biochem Pharmacol. 1989 Nov 15;38(22):3995-4003 PMID: 2532015
  24. Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai.
    Nature. 2006 Sep 14;443(7108):226-9 PMID: 16921385
  25. The complex regulatory function of the ligand-binding domain of the inositol 1,4,5-trisphosphate receptor.
    Cell Calcium. 2008 Jan;43(1):17-27 PMID: 17499849
  26. FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells.
    Blood. 2006 Jan 15;107(2):610-8 PMID: 16174756
  27. Ca2+ and Mn2+ influx through receptor-mediated activation of nonspecific cation channels in mast cells.
    Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3068-72 PMID: 7681994
  28. Organization and function of TRPC channelosomes.
    Pflugers Arch. 2007 Nov;455(2):187-200 PMID: 17486362
  29. Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions.
    Proc Natl Acad Sci U S A. 1990 Jan;87(2):777-81 PMID: 2105489
  30. STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry.
    Curr Biol. 2006 Jul 25;16(14):1465-70 PMID: 16860747
  31. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels.
    Nat Immunol. 2008 Jan;9(1):89-96 PMID: 18059270
  32. Adenophostin A induces spatially restricted calcium signaling in Xenopus laevis oocytes.
    J Biol Chem. 1999 Jul 16;274(29):20643-9 PMID: 10400696
  33. Determinants of adenophostin A binding to inositol trisphosphate receptors.
    Biochem J. 2002 Oct 1;367(Pt 1):113-20 PMID: 12088506
  34. Characterization of the Na+/Ca2+ exchanger on rat mast cells. Evidence for a functional role on the regulation of the cellular response.
    Cell Physiol Biochem. 1999;9(2):53-71 PMID: 10393999
  35. On the mechanism of histamine release induced by thapsigargin from Thapsia garganica L.
    Agents Actions. 1979 Apr;9(1):53-7 PMID: 88885
  36. Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics.
    J Biol Chem. 2009 Jan 9;284(2):728-32 PMID: 19019825
  37. TRPC channels as STIM1-regulated store-operated channels.
    Cell Calcium. 2007 Aug;42(2):205-11 PMID: 17517433
  38. An examination of the secretion-like coupling model for the activation of the Ca2+ release-activated Ca2+ current I(CRAC) in RBL-1 cells.
    J Physiol. 2001 Apr 1;532(Pt 1):55-71 PMID: 11283225
  39. Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle.
    Br J Pharmacol. 2002 Dec;137(8):1207-12 PMID: 12466229
  40. The STIM/Orai coupling machinery.
    Channels (Austin). 2008 Jul-Aug;2(4):261-8 PMID: 18769136
  41. myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.
    J Biol Chem. 1984 Mar 10;259(5):3077-81 PMID: 6607924
  42. 2-Position base-modified analogues of adenophostin A as high-affinity agonists of the D-myo-inositol trisphosphate receptor: in vitro evaluation and molecular modeling.
    J Org Chem. 2008 Mar 7;73(5):1682-92 PMID: 18247493
  43. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.
    Nature. 1983 Nov 3-9;306(5938):67-9 PMID: 6605482
  44. Calcium signalling and cell-fate choice in B cells.
    Nat Rev Immunol. 2007 Oct;7(10):778-89 PMID: 17853903
  45. 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels.
    J Physiol. 2008 Jul 1;586(13):3061-73 PMID: 18403424
  46. Adenophostin-medicated quantal Ca2+ release in the purified and reconstituted inositol 1,4,5-trisphosphate receptor type 1.
    FEBS Lett. 1995 Jul 17;368(2):248-52 PMID: 7628615
  47. Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors.
    Biochem J. 2000 Jan 15;345 Pt 2:357-63 PMID: 10620513
  48. G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation.
    Immunol Lett. 2007 Nov 15;113(2):59-69 PMID: 17919738
  49. Sodium-calcium exchange and store-dependent calcium influx in transfected chinese hamster ovary cells expressing the bovine cardiac sodium-calcium exchanger. Acceleration of exchange activity in thapsigargin-treated cells.
    J Biol Chem. 1996 Mar 8;271(10):5378-85 PMID: 8621391
  50. Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells.
    J Pharmacol Exp Ther. 2003 Jun;305(3):1212-21 PMID: 12626656
  51. Xestospongin C empties the ER calcium store but does not inhibit InsP3-induced Ca2+ release in cultured dorsal root ganglia neurones.
    Cell Calcium. 2002 Jul;32(1):49-52 PMID: 12127062
  52. Complete primary structure of a human plasma membrane Ca2+ pump.
    J Biol Chem. 1988 Oct 5;263(28):14152-9 PMID: 2844759
  53. Depolarization of rat basophilic leukemia cells inhibits calcium uptake and exocytosis.
    J Cell Biol. 1987 Mar;104(3):783-92 PMID: 2950123
  54. Activation of phospholipase C-Ca2+ system by sphingosine 1-phosphate in CHO cells transfected with Edg-3, a putative lipid receptor.
    FEBS Lett. 1999 Jan 22;443(1):25-30 PMID: 9928946
  55. Inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae is linked to actin filaments.
    J Cell Sci. 1995 Jan;108 ( Pt 1):7-15 PMID: 7738118
  56. Calcium signaling.
    Cell. 2007 Dec 14;131(6):1047-58 PMID: 18083096
  57. Regulation of the inositol 1,4,5-trisphosphate receptor by tyrosine phosphorylation.
    Science. 1996 Jun 7;272(5267):1492-4 PMID: 8633244
  58. Recombinant expression of the plasma membrane Na(+)/Ca(2+) exchanger affects local and global Ca(2+) homeostasis in Chinese hamster ovary cells.
    J Biol Chem. 2002 Oct 11;277(41):38693-9 PMID: 12145298
  59. Slow calcium-dependent inactivation of depletion-activated calcium current. Store-dependent and -independent mechanisms.
    J Biol Chem. 1995 Jun 16;270(24):14445-51 PMID: 7540169
  60. The characterization and quantification of antigen-induced Ca2+ oscillations in a rat basophilic leukaemia cell line (RBL-2H3).
    Cell Calcium. 1999 Dec;26(6):261-9 PMID: 10668564
  61. Amplification of CRAC current by STIM1 and CRACM1 (Orai1).
    Nat Cell Biol. 2006 Jul;8(7):771-3 PMID: 16733527
  62. Sorting of calcium signals at the junctions of endoplasmic reticulum and mitochondria.
    Cell Calcium. 2001 Apr;29(4):249-62 PMID: 11243933
  63. Quantification of calcium signal transmission from sarco-endoplasmic reticulum to the mitochondria.
    J Physiol. 2000 Dec 15;529 Pt 3:553-64 PMID: 11118489
  64. Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells.
    Br J Pharmacol. 2002 Apr;135(8):1959-66 PMID: 11959799
  65. Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b.
    J Cell Biol. 2000 Jun 12;149(6):1235-48 PMID: 10851021
  66. ATP-dependent Ca++-extrusion from human red cells.
    Experientia. 1966 Jun 15;22(6):364-5 PMID: 5961668
  67. A plethora of interacting organellar Ca2+ stores.
    Curr Opin Cell Biol. 2005 Apr;17(2):135-40 PMID: 15780589
  68. The interrelations between the transport of sodium and calcium in mitochondria of various mammalian tissues.
    Eur J Biochem. 1978 Jan 2;82(1):25-31 PMID: 23291
  69. Orai1 mediates the interaction between STIM1 and hTRPC1 and regulates the mode of activation of hTRPC1-forming Ca2+ channels.
    J Biol Chem. 2008 Sep 12;283(37):25296-25304 PMID: 18644792
  70. The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria.
    Biochem J. 1978 Nov 15;176(2):463-74 PMID: 33670
  71. A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart.
    J Physiol. 1883 Jan;4(1):29-42.3 PMID: 16991336
  72. 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels.
    Cell Calcium. 2003 Jul;34(1):97-108 PMID: 12767897
  73. 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.
    Br J Pharmacol. 2008 Apr;153(8):1697-705 PMID: 18297105
  74. Ca2+-store-dependent and -independent reversal of Stim1 localization and function.
    J Cell Sci. 2008 Mar 15;121(Pt 6):762-72 PMID: 18285445
  75. No association between CALHM1 and Alzheimer's disease risk.
    Cell. 2008 Dec 12;135(6):993-4; author reply 994-6 PMID: 19070563
  76. Exocytotic fusion is activated by Rab3a peptides.
    Nature. 1992 Nov 19;360(6401):270-3 PMID: 1331813
  77. STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels.
    Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4040-5 PMID: 16537481
  78. Structure and expression of the rat inositol 1,4,5-trisphosphate receptor.
    J Biol Chem. 1990 Jul 25;265(21):12679-85 PMID: 2165071
  79. Overlapping effects of S3 stalk segment mutations on the affinity of Ca2+-ATPase (SERCA) for thapsigargin and cyclopiazonic acid.
    Biochemistry. 1999 Nov 23;38(47):15522-7 PMID: 10569935
  80. Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors.
    Mol Pharmacol. 1999 May;55(5):787-94 PMID: 10220556
  81. Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma-membrane calcium-ATPase in human T cells.
    J Physiol. 2002 Jun 15;541(Pt 3):877-94 PMID: 12068047
  82. Rapid turnover of calcium in the endoplasmic reticulum during signaling. Studies with cameleon calcium indicators.
    J Biol Chem. 2000 Aug 4;275(31):23648-53 PMID: 10811650
  83. RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability.
    J Biol Chem. 2003 Aug 29;278(35):33492-500 PMID: 12766172
  84. Division of labor: specialization of sphingosine kinases in mast cells.
    Immunity. 2007 Mar;26(3):271-3 PMID: 17376388
  85. Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2.
    Biochem Biophys Res Commun. 2008 Apr 25;369(1):240-6 PMID: 18166150
  86. Adenophostins, newly discovered metabolites of Penicillium brevicompactum, act as potent agonists of the inositol 1,4,5-trisphosphate receptor.
    J Biol Chem. 1994 Jan 7;269(1):369-72 PMID: 8276820
  87. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1.
    J Biol Chem. 2006 Aug 25;281(34):24979-90 PMID: 16807233
  88. Allergy therapy: the therapeutic potential of targeting sphingosine kinase signalling in mast cells.
    Eur J Immunol. 2008 Nov;38(11):2969-74 PMID: 18924207
  89. Presenilin: RIP and beyond.
    Semin Cell Dev Biol. 2009 Apr;20(2):201-10 PMID: 19073272
  90. Role of the microtubule cytoskeleton in the function of the store-operated Ca2+ channel activator STIM1.
    J Cell Sci. 2007 Nov 1;120(Pt 21):3762-71 PMID: 17925382
  91. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4.
    Nat Immunol. 2007 Mar;8(3):312-20 PMID: 17293867
  92. Effects of calcium buffers and calbindin-D28k upon histamine-induced calcium oscillations and calcium waves in HeLa cells.
    Cell Calcium. 2003 Aug;34(2):131-44 PMID: 12810055
  93. Linking calcium to Abeta and Alzheimer's disease.
    Neuron. 2008 Jul 31;59(2):190-4 PMID: 18667147
  94. Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrations.
    J Biol Chem. 1991 Jul 25;266(21):13503-6 PMID: 1830305
  95. Specific structural requirements for the inhibitory effect of thapsigargin on the Ca2+ ATPase SERCA.
    J Biol Chem. 2004 Apr 23;279(17):17973-9 PMID: 14970206
  96. TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach.
    Am J Physiol Gastrointest Liver Physiol. 2003 Apr;284(4):G604-16 PMID: 12631560
  97. Imaging [Ca2+]i dynamics during signal transduction.
    Cell Calcium. 1990 Feb-Mar;11(2-3):145-55 PMID: 2141302
  98. The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions.
    J Cell Biol. 2006 Sep 11;174(6):815-25 PMID: 16966423
  99. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.
    Cell. 2003 Sep 19;114(6):777-89 PMID: 14505576
  100. Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase.
    FEBS Lett. 1994 Mar 14;341(1):19-22 PMID: 7511111
  101. Inositol trisphosphate and diacylglycerol as second messengers.
    Biochem J. 1984 Jun 1;220(2):345-60 PMID: 6146314
  102. The cycling of calcium, sodium, and protons across the inner membrane of cardiac mitochondria.
    Eur J Biochem. 1978 Nov 15;91(2):599-608 PMID: 32035
  103. Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport.
    Biochem J. 2007 Sep 15;406(3):365-82 PMID: 17716241
  104. Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.
    Nature. 1984 Jun 7-13;309(5968):562-4 PMID: 6328320
  105. Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium.
    J Biol Chem. 1994 Sep 9;269(36):22628-35 PMID: 8077214
  106. 2-aminoethoxydiphenyl borate inhibits agonist-induced Ca2+ signals by blocking inositol trisphosphate formation in acutely dissociated mouse pancreatic acinar cells.
    Pflugers Arch. 2004 Sep;448(6):592-5 PMID: 15197598
  107. Localization of Ca2+ extrusion sites in pancreatic acinar cells.
    J Biol Chem. 1996 Mar 29;271(13):7615-9 PMID: 8631796
  108. The relationship between histamine secretion and 45calcium uptake by mast cells.
    J Physiol. 1977 Sep;271(1):193-214 PMID: 72146
  109. Inositol 1,4,5-trisphosphate receptors as signal integrators.
    Annu Rev Biochem. 2004;73:437-65 PMID: 15189149
  110. STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels.
    Cell. 2007 Dec 28;131(7):1327-39 PMID: 18160041
  111. Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells.
    Blood. 2004 Oct 15;104(8):2410-7 PMID: 15217825
  112. Calcium release-activated calcium current (ICRAC) is a direct target for sphingosine.
    J Biol Chem. 1998 Sep 25;273(39):25020-30 PMID: 9737958
  113. IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.
    J Biol Chem. 2006 Feb 3;281(5):2515-25 PMID: 16316995
  114. 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release.
    J Biochem. 1997 Sep;122(3):498-505 PMID: 9348075
  115. ATP-dependent adenophostin activation of inositol 1,4,5-trisphosphate receptor channel gating: kinetic implications for the durations of calcium puffs in cells.
    J Gen Physiol. 2001 Apr;117(4):299-314 PMID: 11279251
  116. IP(3) receptors: the search for structure.
    Trends Biochem Sci. 2004 Apr;29(4):210-9 PMID: 15082315
  117. Nuclear and cytosolic calcium are regulated independently.
    Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2975-80 PMID: 12606721
  118. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
    Nature. 2006 May 11;441(7090):179-85 PMID: 16582901
  119. New developments in mast cell biology.
    Nat Immunol. 2008 Nov;9(11):1215-23 PMID: 18936782
  120. Predetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytes.
    J Physiol. 2001 Feb 1;530(Pt 3):417-29 PMID: 11158273
  121. Depletion of intracellular calcium stores activates a calcium current in mast cells.
    Nature. 1992 Jan 23;355(6358):353-6 PMID: 1309940
  122. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation.
    Nat Immunol. 2002 Aug;3(8):741-8 PMID: 12089510
  123. Movement of strontium ions into mast cells and its relationship to the secretory response.
    J Physiol. 1977 Sep;271(1):233-51 PMID: 72148
  124. Endoplasmic reticulum/mitochondria calcium cross-talk.
    Novartis Found Symp. 2007;287:122-31; discussion 131-9 PMID: 18074635
  125. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.
    Science. 2006 May 26;312(5777):1220-3 PMID: 16645049
  126. The mechanism of anaphylactic histamine release from rabbit leucocytes.
    Immunology. 1968 Nov;15(5):743-9 PMID: 4177078
  127. Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.
    J Biol Chem. 2007 Jun 15;282(24):17548-56 PMID: 17452328
  128. New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells.
    Trends Mol Med. 2007 Mar;13(3):103-7 PMID: 17267286
  129. The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells.
    J Allergy Clin Immunol. 2004 Jul;114(1):66-72 PMID: 15241346
  130. Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors.
    J Physiol. 2001 Oct 1;536(Pt 1):3-19 PMID: 11579153
  131. Alzheimer's disease. Fresh evidence points to an old suspect: calcium.
    Science. 2007 Oct 19;318(5849):384-5 PMID: 17947560
  132. STOICHIOMETRY OF RESPIRATORY STIMULATION, ACCUMULATION OF CA++ AND PHOSPHATE, AND OXIDATIVE PHOSPHORYLATION IN RAT LIVER MITOCHONDRIA.
    J Biol Chem. 1964 Nov;239:3971-80 PMID: 14257633
  133. Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 Complex.
    J Biol Chem. 2007 Oct 5;282(40):29678-90 PMID: 17684017
  134. Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase.
    J Biol Chem. 1999 Feb 12;274(7):3994-9 PMID: 9933590
  135. Inhibition of the antigen-induced activation of RBL-2H3 cells by cetiedil and some of its analogues.
    Eur J Pharmacol. 2004 Jan 12;483(2-3):107-16 PMID: 14729097
  136. All-or-none activation of CRAC channels by agonist elicits graded responses in populations of mast cells.
    J Immunol. 2007 Oct 15;179(8):5255-63 PMID: 17911611
  137. Modulation of Ca2+ signaling by Na+/Ca2+ exchangers in mast cells.
    J Immunol. 2005 Jan 1;174(1):119-30 PMID: 15611234
  138. The alliance of sphingosine-1-phosphate and its receptors in immunity.
    Nat Rev Immunol. 2008 Oct;8(10):753-63 PMID: 18787560
  139. Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition.
    J Biol Chem. 2002 Jun 14;277(24):21617-23 PMID: 11943785
  140. Orai1 and STIM reconstitute store-operated calcium channel function.
    J Biol Chem. 2006 Jul 28;281(30):20661-20665 PMID: 16766533
  141. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.
    Biochemistry. 1980 May 27;19(11):2396-404 PMID: 6770893
  142. 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release.
    FASEB J. 2002 Aug;16(10):1145-50 PMID: 12153982
  143. Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors.
    FEBS Lett. 2003 Nov 20;554(3):443-9 PMID: 14623109
  144. Calcium pumps of plasma membrane and cell interior.
    Curr Mol Med. 2004 May;4(3):323-35 PMID: 15101689
  145. Calcium gradients and the Golgi.
    Cell Calcium. 2006 Nov-Dec;40(5-6):505-12 PMID: 17023044
  146. Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activation.
    J Biol Chem. 2003 Jun 13;278(24):21649-54 PMID: 12686562
  147. Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores.
    Nature. 1989 May 4;339(6219):64-7 PMID: 2469965
  148. Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ stores.
    J Biol Chem. 2006 Sep 22;281(38):28254-64 PMID: 16870612
  149. Calcium-dependent clustering of inositol 1,4,5-trisphosphate receptors.
    Mol Biol Cell. 1998 Jun;9(6):1465-78 PMID: 9614187
  150. Single-channel recording of a store-operated Ca2+ channel in Jurkat T lymphocytes.
    Science. 1999 Feb 5;283(5403):836-9 PMID: 9933165
  151. The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.
    J Biol Chem. 1984 Jun 10;259(11):7129-36 PMID: 6202691
  152. 2-Aminoethoxydiphenyl borate (2-APB) inhibits capacitative calcium entry independently of the function of inositol 1,4,5-trisphosphate receptors.
    Recept Channels. 2001;7(6):429-39 PMID: 11918346
  153. 2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.
    J Biol Chem. 2008 Jul 18;283(29):20261-7 PMID: 18499656
  154. Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor.
    Nature. 1996 Apr 18;380(6575):634-6 PMID: 8602265
  155. Mast cells chemotax to laminin with enhancement after IgE-mediated activation.
    J Immunol. 1989 Dec 15;143(12):4188-92 PMID: 2592771
  156. Alzheimer's disease: The latest suspect.
    Nature. 2008 Aug 7;454(7205):706-8 PMID: 18685694
  157. Calcium signalling in lymphocyte activation and disease.
    Nat Rev Immunol. 2007 Sep;7(9):690-702 PMID: 17703229
  158. Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.
    J Gen Physiol. 2006 May;127(5):525-37 PMID: 16636202
  159. Polarized expression of Ca2+ pumps in pancreatic and salivary gland cells. Role in initiation and propagation of [Ca2+]i waves.
    J Biol Chem. 1997 Jun 20;272(25):15771-6 PMID: 9188473
  160. STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.
    Nat Cell Biol. 2007 Jun;9(6):636-45 PMID: 17486119
  161. The plasma membrane Ca2+ ATPase of animal cells: structure, function and regulation.
    Arch Biochem Biophys. 2008 Aug 1;476(1):65-74 PMID: 18328800
  162. Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entry.
    J Biol Chem. 2006 Nov 24;281(47):35855-62 PMID: 17020874
  163. IgE receptor and signal transduction in mast cells and basophils.
    Curr Opin Immunol. 2008 Dec;20(6):717-23 PMID: 18822373
  164. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.
    EMBO J. 2002 Jan 15;21(1-2):83-92 PMID: 11782428
  165. Biphasic regulation of mitochondrial Ca2+ uptake by cytosolic Ca2+ concentration.
    Curr Biol. 2006 Aug 22;16(16):1672-7 PMID: 16920631
  166. Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors.
    EMBO J. 1998 May 15;17(10):2830-7 PMID: 9582276
  167. Presenilin-mediated modulation of capacitative calcium entry.
    Neuron. 2000 Sep;27(3):561-72 PMID: 11055438
  168. Role of the inositol 1,4,5-trisphosphate receptor in Ca(2+) feedback inhibition of calcium release-activated calcium current (I(crac)).
    J Biol Chem. 1999 Nov 12;274(46):32881-8 PMID: 10551852
  169. Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.
    Neuron. 2008 Jun 26;58(6):871-83 PMID: 18579078
  170. Mitochondria and calcium signaling.
    Cell Calcium. 2005 Sep-Oct;38(3-4):311-7 PMID: 16087232
  171. Primary structure, chromosomal localization and expression in immune cells of the murine ORAI and STIM genes.
    Cell Calcium. 2007 Oct-Nov;42(4-5):439-46 PMID: 17659338
  172. Function and pharmacology of TRPM cation channels.
    Naunyn Schmiedebergs Arch Pharmacol. 2005 Apr;371(4):307-14 PMID: 15843919
  173. Free calcium increases explosively in activating medaka eggs.
    Proc Natl Acad Sci U S A. 1977 Feb;74(2):623-7 PMID: 322135
  174. A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells.
    Biochem J. 1988 Jul 1;253(1):81-6 PMID: 3138987
  175. Calcium-independent phosphoinositide breakdown in rat basophilic leukemia cells. Evidence for an early rise in inositol 1,4,5-trisphosphate which precedes the rise in other inositol phosphates and in cytoplasmic calcium.
    J Biol Chem. 1987 Aug 25;262(24):11449-54 PMID: 3040702
  176. The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis.
    Immunity. 2007 Mar;26(3):287-97 PMID: 17346996
  177. Store-operated Ca2+ entry depends on mitochondrial Ca2+ uptake.
    EMBO J. 2002 Dec 16;21(24):6744-54 PMID: 12485995
  178. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components.
    J Biol Chem. 2007 Mar 23;282(12):9105-16 PMID: 17224452
  179. Na(+)-dependent Ca(2+) transport modulates the secretory response to the Fcepsilon receptor stimulus of mast cells.
    Biophys J. 2000 Dec;79(6):2975-86 PMID: 11106605
  180. Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry.
    J Biol Chem. 2001 May 11;276(19):15945-52 PMID: 11278938
  181. Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli.
    Br J Pharmacol. 1989 Jul;97(3):898-904 PMID: 2474353
  182. The type 3 inositol 1,4,5-trisphosphate receptor is concentrated at the tight junction level in polarized MDCK cells.
    J Cell Sci. 2003 Jul 1;116(Pt 13):2791-803 PMID: 12759372
  183. IgE receptor-mediated depolarization of rat basophilic leukemia cells measured with the fluorescent probe bis-oxonol.
    J Immunol. 1987 Mar 1;138(5):1564-70 PMID: 2949017
  184. Biochemical properties and cellular localisation of STIM proteins.
    Cell Calcium. 2007 Aug;42(2):123-32 PMID: 17382385
  185. Antigen and thapsigargin promote influx of Ca2+ in rat basophilic RBL-2H3 cells by ostensibly similar mechanisms that allow filling of inositol 1,4,5-trisphosphate-sensitive and mitochondrial Ca2+ stores.
    Biochem J. 1994 Dec 1;304 ( Pt 2):431-40 PMID: 7998977
  186. On the conservation of fast calcium wave speeds.
    Cell Calcium. 2002 Oct;32(4):217-29 PMID: 12379182
  187. Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitro and in situ in single cardiac myocytes.
    J Biol Chem. 1998 Apr 24;273(17):10223-31 PMID: 9553073
  188. Signaling microdomains define the specificity of receptor-mediated InsP(3) pathways in neurons.
    Neuron. 2002 Apr 11;34(2):209-20 PMID: 11970863
  189. The IP3 receptor/Ca2+ channel and its cellular function.
    Biochem Soc Symp. 2007;(74):9-22 PMID: 17233576
  190. Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry.
    J Biol Chem. 2008 Jul 11;283(28):19265-73 PMID: 18487204
  191. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance.
    Nat Immunol. 2008 Apr;9(4):432-43 PMID: 18327260
  192. Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules.
    J Immunol. 1995 May 15;154(10):5391-402 PMID: 7730640
  193. STIM1, an essential and conserved component of store-operated Ca2+ channel function.
    J Cell Biol. 2005 May 9;169(3):435-45 PMID: 15866891
  194. Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor.
    Neuron. 1999 Aug;23(4):799-808 PMID: 10482245
  195. Ca2+ entry through plasma membrane IP3 receptors.
    Science. 2006 Jul 14;313(5784):229-33 PMID: 16840702
  196. Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps.
    Cell Calcium. 1999 Jul-Aug;26(1-2):9-13 PMID: 10892566
  197. Novel Ca2+ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca2+ mobilization.
    Trends Neurosci. 1993 Sep;16(9):371-6 PMID: 7694408
  198. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells.
    Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16394-9 PMID: 17050692
  199. Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels.
    J Biol Chem. 2007 Jul 6;282(27):19375-84 PMID: 17463004
  200. The second messenger linking receptor activation to internal Ca release in liver.
    Nature. 1984 May 3-9;309(5963):63-6 PMID: 6325926
  201. Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L.
    Acta Pharm Suec. 1978;15(2):133-40 PMID: 79299
  202. Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.
    J Exp Med. 1989 Jul 1;170(1):245-57 PMID: 2473161
  203. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.
    Curr Biol. 2005 Jul 12;15(13):1235-41 PMID: 16005298
  204. Transient receptor potential cation channels in disease.
    Physiol Rev. 2007 Jan;87(1):165-217 PMID: 17237345
  205. Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels.
    Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2895-900 PMID: 18287061
  206. 2-Aminoethoxydiphenyl borate affects the inositol 1,4,5-trisphosphate receptor, the intracellular Ca2+ pump and the non-specific Ca2+ leak from the non-mitochondrial Ca2+ stores in permeabilized A7r5 cells.
    Cell Calcium. 2001 Feb;29(2):111-6 PMID: 11162848
  207. Characterization of increased K+ permeability associated with the stimulation of receptors for immunoglobulin E on rat basophilic leukemia cells.
    J Biol Chem. 1991 Aug 15;266(23):14912-7 PMID: 1831198
  208. Integrated signalling pathways for mast-cell activation.
    Nat Rev Immunol. 2006 Mar;6(3):218-30 PMID: 16470226
  209. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.
    Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9357-62 PMID: 16751269
  210. STIM1 regulates acidic Ca2+ store refilling by interaction with SERCA3 in human platelets.
    Biochem Pharmacol. 2008 Jun 1;75(11):2157-64 PMID: 18439569
  211. Calcium signaling in immune cells.
    Nat Immunol. 2009 Jan;10(1):21-7 PMID: 19088738
  212. Calcium release-activated calcium current in rat mast cells.
    J Physiol. 1993 Jun;465:359-86 PMID: 8229840
  213. Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand.
    Nature. 2002 Dec 12;420(6916):696-700 PMID: 12442173
  214. Stochastic modeling of calcium in 3D geometry.
    Biophys J. 2009 Mar 4;96(5):1691-706 PMID: 19254531
  215. Imaging asynchronous changes in intracellular Ca2+ in individual stimulated tumor mast cells.
    Proc Natl Acad Sci U S A. 1988 Mar;85(6):1854-8 PMID: 3162312
  216. Effect of adenophostin A on Ca2+ entry and calcium release-activated calcium current (Icrac) in rat basophilic leukemia cells.
    J Biol Chem. 1998 Nov 27;273(48):31815-21 PMID: 9822648
  217. The calcium signal and phosphatidylinositol breakdown in 2H3 cells.
    J Biol Chem. 1984 Jun 10;259(11):7137-42 PMID: 6202692
  218. Cytoplasmic calcium oscillations and store-operated calcium influx.
    J Physiol. 2008 Jul 1;586(13):3055-9 PMID: 18388136
  219. Recent breakthroughs in the molecular mechanism of capacitative calcium entry (with thoughts on how we got here).
    Cell Calcium. 2007 Aug;42(2):103-10 PMID: 17349691
  220. Calmodulin increases the sensitivity of type 3 inositol-1,4, 5-trisphosphate receptors to Ca(2+) inhibition in human bronchial mucosal cells.
    Mol Pharmacol. 2000 Mar;57(3):564-7 PMID: 10692497
  221. STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation.
    FASEB J. 2008 Mar;22(3):752-61 PMID: 17905723
  222. Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse.
    Cell Calcium. 2002 Jul;32(1):39-47 PMID: 12127061
  223. Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway.
    J Biol Chem. 2006 Sep 8;281(36):26569-77 PMID: 16846981
  224. IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells.
    J Biol Chem. 1991 Dec 25;266(36):24237-40 PMID: 1662204
  225. Reaction diffusion modeling of calcium dynamics with realistic ER geometry.
    Biophys J. 2006 Jul 15;91(2):537-57 PMID: 16617072
  226. Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.
    Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6295-9 PMID: 8392195
  227. Modulation of mammalian inositol 1,4,5-trisphosphate receptor isoforms by calcium: a role of calcium sensor region.
    Biophys J. 2005 Feb;88(2):1056-69 PMID: 15531634
  228. Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins.
    Biochem J. 2001 Aug 1;357(Pt 3):673-85 PMID: 11463338
  229. Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels.
    J Biol Chem. 2008 May 9;283(19):12935-40 PMID: 18326500
  230. Convergence of Fc gamma receptor IIA and Fc gamma receptor IIIB signaling pathways in human neutrophils.
    J Immunol. 2000 Jan 1;164(1):350-60 PMID: 10605030
  231. A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.
    J Biol Chem. 2009 Mar 27;284(13):8421-6 PMID: 19189966
  232. Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells: roles of cytosolic calcium and protein tyrosine kinases.
    Biochim Biophys Acta. 1995 Feb 16;1265(1):79-88 PMID: 7857988
  233. Ca(2+)-ATPase inhibitor, cyclopiazonic acid, releases Ca2+ from intracellular stores in RBL-2H3 mast cells and activates a Ca2+ influx pathway that is permeable to sodium and manganese.
    J Cell Physiol. 1995 Jul;164(1):205-13 PMID: 7790392
  234. Effect of lanthanide ions on histamine secretion from rat peritoneal mast cells.
    Br J Pharmacol. 1981 Feb;72(2):341-7 PMID: 6163496
  235. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane.
    J Biol Chem. 1989 Jul 25;264(21):12266-71 PMID: 2663854
  236. Structural changes in the calcium pump accompanying the dissociation of calcium.
    Nature. 2002 Aug 8;418(6898):605-11 PMID: 12167852
  237. The effect of mitochondrial inhibitors on calcium homeostasis in tumor mast cells.
    Am J Physiol. 1990 Feb;258(2 Pt 1):C217-26 PMID: 2137675
  238. Orai1 subunit stoichiometry of the mammalian CRAC channel pore.
    J Physiol. 2008 Jan 15;586(2):419-25 PMID: 18006576
  239. Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum.
    J Biol Chem. 1989 Oct 25;264(30):17816-23 PMID: 2530215
  240. FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
    J Biol Chem. 1998 Apr 17;273(16):9393-402 PMID: 9545263
  241. The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response.
    Br J Pharmacol. 1985 Jul;85(3):705-12 PMID: 2411328
  242. Effects of cyclopiazonic acid, a novel Ca(2+)-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle.
    Br J Pharmacol. 1992 May;106(1):208-14 PMID: 1387024
  243. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.
    Nature. 2005 Oct 6;437(7060):902-5 PMID: 16208375
  244. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.
    Cell. 2006 Sep 8;126(5):981-93 PMID: 16959576
  245. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.
    Cell. 1996 May 31;85(5):661-71 PMID: 8646775
  246. Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.
    J Biol Chem. 1993 Jan 25;268(3):1749-56 PMID: 8420951
  247. Adenophostins A and B: potent agonists of inositol-1,4,5-trisphosphate receptor produced by Penicillium brevicompactum. Structure elucidation.
    J Antibiot (Tokyo). 1994 Jan;47(1):95-100 PMID: 8119867
  248. Carbachol induces secretion in a mast cell line (RBL-2H3) transfected with the ml muscarinic receptor gene.
    FEBS Lett. 1991 Sep 2;289(1):47-50 PMID: 1832647
  249. Increased vascular smooth muscle contractility in TRPC6-/- mice.
    Mol Cell Biol. 2005 Aug;25(16):6980-9 PMID: 16055711
  250. Distribution of inositol 1,4,5-trisphosphate receptor isoforms, SERCA isoforms and Ca2+ binding proteins in RBL-2H3 rat basophilic leukemia cells.
    Cell Calcium. 1997 Dec;22(6):475-86 PMID: 9502197
  251. Calcium-dependent enhancement of depletion-activated calcium current in Jurkat T lymphocytes.
    J Membr Biol. 1996 Mar;150(1):63-71 PMID: 8699480
  252. Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions.
    Mol Biol Cell. 2009 Jan;20(1):389-99 PMID: 18987344
  253. Localised and rapid Ca2+ micro-events in human neutrophils: conventional Ca2+ puffs and global waves without peripheral-restriction or wave cycling.
    Cell Calcium. 2007 Jun;41(6):525-36 PMID: 17324458
  254. Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum.
    Nature. 1991 Jun 27;351(6329):751-4 PMID: 1648178
  255. The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrations.
    Annu Rev Pharmacol Toxicol. 2009;49:395-426 PMID: 19281310
  256. Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell line.
    J Immunol. 2008 Feb 15;180(4):2233-9 PMID: 18250430
  257. CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.
    Curr Biol. 2007 May 1;17(9):794-800 PMID: 17442569
  258. Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency.
    J Biol Chem. 2004 Sep 24;279(39):40328-36 PMID: 15269216
  259. Correlating Ca2+ responses and secretion in individual RBL-2H3 mucosal mast cells.
    J Biol Chem. 1997 Dec 12;272(50):31225-9 PMID: 9395446
  260. Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400.
    Nature. 1989 Nov 2;342(6245):32-8 PMID: 2554142
  261. Our perception of the mast cell from Paul Ehrlich to now.
    Eur J Immunol. 2009 Jan;39(1):11-25 PMID: 19130582
  262. Structural role of countertransport revealed in Ca(2+) pump crystal structure in the absence of Ca(2+).
    Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14489-96 PMID: 16150713
  263. Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5.
    Genomics. 1996 Oct 15;37(2):253-6 PMID: 8921403
  264. STUDIES ON THE MECHANISMS OF HYPERSENSITIVITY PHENOMENA. IX. HISTAMINE RELEASE FROM HUMAN LEUKOCYTES BY RAGWEED POLLEN ANTIGEN.
    J Exp Med. 1964 Oct 1;120:507-30 PMID: 14212116
  265. Orai proteins interact with TRPC channels and confer responsiveness to store depletion.
    Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4682-7 PMID: 17360584
  266. Calcium microdomains: organization and function.
    Cell Calcium. 2006 Nov-Dec;40(5-6):405-12 PMID: 17030366
  267. Adenophostin A and ribophostin, but not inositol 1,4,5-trisphosphate or manno-adenophostin, activate the Ca2+ release-activated Ca2+ current, I(CRAC), in weak intracellular Ca2+ buffer.
    Biochem J. 2002 Jan 1;361(Pt 1):133-41 PMID: 11742538
  268. New developments in the signaling mechanisms of the store-operated calcium entry pathway.
    Pflugers Arch. 2008 Nov;457(2):405-15 PMID: 18536932
  269. Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum.
    Nat Cell Biol. 2003 May;5(5):440-6 PMID: 12717445
  270. Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.
    J Clin Invest. 2007 May;117(5):1230-9 PMID: 17431506
  271. Functional KCa3.1 K+ channels are required for human lung mast cell migration.
    Thorax. 2006 Oct;61(10):880-5 PMID: 16809411
  272. Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.
    Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):534-8 PMID: 8290560
  273. Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels.
    Science. 2000 Mar 3;287(5458):1647-51 PMID: 10698739
  274. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.
    Cell. 2008 Jun 27;133(7):1149-61 PMID: 18585350
  275. Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.
    J Biol Chem. 2008 Mar 21;283(12):8014-22 PMID: 18187424
  276. Lysophospholipid receptor-dependent and -independent calcium signaling.
    J Cell Biochem. 2004 Aug 1;92(5):937-48 PMID: 15258917
  277. STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction.
    Mol Cell. 2008 Nov 7;32(3):439-48 PMID: 18995841
  278. Inositol lipids and TRPC channel activation.
    Biochem Soc Symp. 2007;(74):37-45 PMID: 17233578
  279. Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells.
    J Biol Chem. 2002 May 10;277(19):17255-62 PMID: 11856736
  280. Calcium influx in a rat mast cell (RBL-2H3) line. Use of multivalent metal ions to define its characteristics and role in exocytosis.
    J Biol Chem. 1991 Aug 15;266(23):15221-9 PMID: 1869551
  281. Calcium puffs are generic InsP(3)-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses.
    J Cell Sci. 2001 Nov;114(Pt 22):3979-89 PMID: 11739630
  282. cADPR stimulates SERCA activity in Xenopus oocytes.
    Cell Calcium. 2009 Mar;45(3):293-9 PMID: 19131109
  283. Biochemical and functional characterization of Orai proteins.
    J Biol Chem. 2007 Jun 1;282(22):16232-43 PMID: 17293345
  284. TRPC1, a human homolog of a Drosophila store-operated channel.
    Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9652-6 PMID: 7568191
  285. The relative contributions of extracellular and intracellular calcium to secretion from tumor mast cells. Multiple effects of the proton ionophore carbonyl cyanide m-chlorophenylhydrazone.
    J Biol Chem. 1987 Aug 5;262(22):10638-43 PMID: 2440869
  286. The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum.
    EMBO J. 1998 Sep 15;17(18):5298-308 PMID: 9736609
  287. The effect of calcium and pH on the anaphylactic reaction.
    J Physiol. 1958 Feb 17;140(2):272-84 PMID: 13514685
  288. Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases.
    J Biol Chem. 1988 Jun 25;263(18):8646-57 PMID: 2837461
  289. Release of calcium from intracellular stores in rat basophilic leukemia cells monitored with the fluorescent probe chlortetracycline.
    J Cell Physiol. 1990 Jan;142(1):78-88 PMID: 1688862
  290. Plasma membrane Ca(2+)-ATPase: from a housekeeping function to a versatile signaling role.
    Pflugers Arch. 2009 Jan;457(3):657-64 PMID: 18548270
  291. A model for receptor-regulated calcium entry.
    Cell Calcium. 1986 Feb;7(1):1-12 PMID: 2420465
  292. Subcellular distribution of the inositol 1,4,5-trisphosphate receptors: functional relevance and molecular determinants.
    Biol Cell. 2004 Feb;96(1):3-17 PMID: 15093123
  293. The inositol 1,4,5-trisphosphate receptor (IP3R) and its regulators: sometimes good and sometimes bad teamwork.
    Sci STKE. 2006 Nov 28;2006(363):re15 PMID: 17132820
  294. Ca(2+) signaling in antigen receptor-activated B lymphocytes.
    Immunol Rev. 2007 Aug;218:235-46 PMID: 17624956
  295. Localization and function of a calmodulin-apocalmodulin-binding domain in the N-terminal part of the type 1 inositol 1,4,5-trisphosphate receptor.
    Biochem J. 2002 Jul 1;365(Pt 1):269-77 PMID: 11955285
  296. Mast cell ion channels.
    Chem Immunol Allergy. 2005;87:163-178 PMID: 16107771
  297. Altered Ca2+ homeostasis and impaired mitochondrial function in cardiomyopathy.
    Mol Cell Biochem. 2002 Sep;238(1-2):119-27 PMID: 12349899
  298. The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells.
    J Biol Chem. 1993 Aug 15;268(23):16887-90 PMID: 8349579
  299. A GTP-dependent step in the activation mechanism of capacitative calcium influx.
    J Biol Chem. 1993 Oct 5;268(28):20737-40 PMID: 8407897
  300. Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes.
    J Gen Physiol. 1996 May;107(5):597-610 PMID: 8740373
  301. Molecular basis of the CRAC channel.
    Cell Calcium. 2007 Aug;42(2):133-44 PMID: 17482674
  302. C3a and C5a stimulate chemotaxis of human mast cells.
    Blood. 1997 Apr 15;89(8):2863-70 PMID: 9108406
  303. Ca2+ influx through CRAC channels activates cytosolic phospholipase A2, leukotriene C4 secretion, and expression of c-fos through ERK-dependent and -independent pathways in mast cells.
    FASEB J. 2006 Nov;20(13):2381-3 PMID: 17023391
  304. Anticipating antiport in P-type ATPases.
    Trends Biochem Sci. 2008 Apr;33(4):156-60 PMID: 18343670
  305. Stable activation of single Ca2+ release-activated Ca2+ channels in divalent cation-free solutions.
    J Biol Chem. 2001 Jan 12;276(2):1063-70 PMID: 11042187
  306. Capacitative calcium entry revisited.
    Cell Calcium. 1990 Nov-Dec;11(10):611-24 PMID: 1965707
  307. Cross-linking of FcepsilonRI causes Ca2+ mobilization via a sphingosine kinase pathway in a clathrin-dependent manner.
    Cell Calcium. 2009 Feb;45(2):99-108 PMID: 18675457
  308. Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses.
    Nat Immunol. 2008 Jan;9(1):81-8 PMID: 18059272
  309. The molecular basis for cyclopiazonic acid inhibition of the sarcoplasmic reticulum calcium pump.
    J Biol Chem. 2007 Mar 30;282(13):9748-9757 PMID: 17259168
  310. Cytosolic Ca2+ signals depending on the functional state of the Golgi in HeLa cells.
    Cell Calcium. 2005 Nov;38(5):489-95 PMID: 16122795
  311. Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.
    Biochim Biophys Acta. 2006 Dec;1758(12):2016-26 PMID: 16996023
  312. A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases.
    Trends Pharmacol Sci. 1998 Apr;19(4):131-5 PMID: 9612087
  313. The role of the alkaline earth ions in anaphylactic histamine secretion.
    J Physiol. 1972 Aug;224(3):753-69 PMID: 4116105
  314. Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage.
    Agents Actions. 1989 Apr;27(1-2):17-23 PMID: 2787587
  315. Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release.
    Science. 1991 Apr 19;252(5004):443-6 PMID: 2017683
  316. Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells.
    FEBS Lett. 2005 Apr 11;579(10):2051-7 PMID: 15811317
  317. STIM1 knockdown reveals that store-operated Ca2+ channels located close to sarco/endoplasmic Ca2+ ATPases (SERCA) pumps silently refill the endoplasmic reticulum.
    J Biol Chem. 2007 Apr 13;282(15):11456-64 PMID: 17283081
  318. Immunoglobulin E receptor cross-linking induces oscillations in intracellular free ionized calcium in individual tumor mast cells.
    J Biol Chem. 1989 Nov 25;264(33):19730-9 PMID: 2531141
  319. Orai1 is an essential pore subunit of the CRAC channel.
    Nature. 2006 Sep 14;443(7108):230-3 PMID: 16921383
  320. Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.
    J Biol Chem. 2008 Jun 20;283(25):17662-71 PMID: 18420579
  321. TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.
    Cell. 2002 May 3;109(3):397-407 PMID: 12015988
Article Info
Journal
Critical reviews in immunology
Abbr.
Crit Rev Immunol
ISSN
1040-8401
DOI
10.1615/critrevimmunol.v29.i2.40
Published
2009-00-00
Pages
155-86
Language
English
Region
United States
NLM ID
8914819
PMCID
PMC2954050
Subset
IM
Grants
Intramural NIH HHS · ZIA HL000993-23 · United States
External Links
PubMed source DOI: 10.1615/critrevimmunol.v29.i2.40 PMC Full Text View journal details
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