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PMID: 19073272 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Presenilin: RIP and beyond.

Seminars in cell & developmental biology ·Vol. 20 ·No. 2 ·2009-04-00 ·Pages 201-10

Hass MR, Sato C, Kopan R, Zhao G

Abstract

Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through gamma-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of beta-catenin function, protein trafficking, calcium regulation, and apoptosis.

MeSH Terms
Amyloid Precursor Protein Secretases/metabolism Humans Membrane Proteins/metabolism Models, Biological Presenilins/metabolism Protein Transport Signal Transduction
Chemicals
Membrane Proteins Presenilins Amyloid Precursor Protein Secretases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hass Matthew R
Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO, United States.
Sato Chihiro
Kopan Raphael
Zhao Guojun
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Article Info
Journal
Seminars in cell & developmental biology
Abbr.
Semin Cell Dev Biol
ISSN
1084-9521
DOI
10.1016/j.semcdb.2008.11.014
Published
2009-04-00
Epub
2008-00-27
Pages
201-10
Language
English
Region
England
NLM ID
9607332
PMCID
PMC2693421
Subset
IM
Grants
NCI NIH HHS · P50 CA094056 · United States
NIA NIH HHS · P50 AG05681 · United States
NIA NIH HHS · P50 AG005681 · United States
NIA NIH HHS · R01 AG025973-04 · United States
NCI NIH HHS · P50 CA094056-090001 · United States
NIGMS NIH HHS · F32 GM083604 · United States
NIA NIH HHS · R01 AG025973 · United States
NIA NIH HHS · AG025973 · United States
NIGMS NIH HHS · F32GM083604 · United States
External Links
PubMed source DOI: 10.1016/j.semcdb.2008.11.014 PMC Full Text View journal details
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