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PMID: 18787560 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

The alliance of sphingosine-1-phosphate and its receptors in immunity.

Nature reviews. Immunology ·Vol. 8 ·No. 10 ·2008-10-00 ·Pages 753-63

Rivera J, Proia RL, Olivera A

Abstract

Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the immune function of S1P results from the engagement of a family of G-protein-coupled receptors (S1PR1-S1PR5). Recent findings on the role of S1P in immunosurveillance, the discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new advances in understanding the mechanism by which S1P affects immune-cell function indicate that the alliance between S1P and its receptors has a fundamental role in immunity.

MeSH Terms
Animals Cell Movement Chemotaxis Dendritic Cells/immunology,metabolism Humans Lymphocytes/immunology,metabolism Lysophospholipids/immunology,metabolism Macrophages/immunology,metabolism Mast Cells/immunology,metabolism Receptors, Lysosphingolipid/immunology,metabolism Signal Transduction Sphingosine/analogs & derivatives,immunology,metabolism
Chemicals
Lysophospholipids Receptors, Lysosphingolipid sphingosine 1-phosphate Sphingosine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rivera Juan
Laboratory of Immune Cell Signaling, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA. juan.rivera@nih.gov
Proia Richard L
Olivera Ana
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2400
Email
juan.rivera@nih.gov
Published
2008-10-00
Pages
753-63
Language
English
Region
England
NLM ID
101124169
PMCID
PMC2600775
Subset
IM
Grants
Intramural NIH HHS · Z01 AR041155-01 · United States
External Links
PubMed source DOI: 10.1038/nri2400 PMC Full Text View journal details
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