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PMID: 17224922 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Translational control of retroviruses.

Nature reviews. Microbiology ·Vol. 5 ·No. 2 ·2007-02-00 ·Pages 128-40

Balvay L, Lopez Lastra M, Sargueil B, Darlix JL, Ohlmann T

Abstract

All replication-competent retroviruses contain three main reading frames, gag, pol and env, which are used for the synthesis of structural proteins, enzymes and envelope proteins respectively. Complex retroviruses, such as lentiviruses, also code for regulatory and accessory proteins that have essential roles in viral replication. The concerted expression of these genes ensures the efficient polypeptide production required for the assembly and release of new infectious progeny virions. Retroviral protein synthesis takes place in the cytoplasm and depends exclusively on the translational machinery of the host infected cell. Therefore, not surprisingly, retroviruses have developed RNA structures and strategies to promote robust and efficient expression of viral proteins in a competitive cellular environment.

MeSH Terms
Animals Eukaryotic Cells/virology Gene Expression Regulation, Viral Humans Protein Biosynthesis RNA, Viral/chemistry,metabolism Retroviridae/genetics,metabolism,physiology Viral Proteins/genetics,metabolism Virus Replication
Chemicals
RNA, Viral Viral Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Balvay Laurent
Ecole Normale Supérieure de Lyon, Unité de Virologie Humaine, IFR 128, Lyon, F-69364 France.
Lopez Lastra Marcelo
Sargueil Bruno
Darlix Jean-Luc
Ohlmann Théophile
References (142)
142 references, click to expand
  1. Conducting the initiation of protein synthesis: the role of eIF4G.
    Biol Cell. 2003 May-Jun;95(3-4):141-56 PMID: 12867079
  2. Autogenous regulation of RNA translation and packaging by Rous sarcoma virus Pr76gag.
    J Virol. 1996 Oct;70(10):6642-52 PMID: 8794299
  3. Characterization of an internal ribosomal entry segment in the 5' leader of murine leukemia virus env RNA.
    J Virol. 2000 Jan;74(2):846-50 PMID: 10623747
  4. Picornavirus IRES: structure function relationship.
    Curr Pharm Des. 2004;10(30):3757-67 PMID: 15579069
  5. Phylogenetic and physical analysis of the 5' leader RNA sequences of avian retroviruses.
    Nucleic Acids Res. 1991 Dec 25;19(24):6929-34 PMID: 1662367
  6. Nonreciprocal packaging of human immunodeficiency virus type 1 and type 2 RNA: a possible role for the p2 domain of Gag in RNA encapsidation.
    J Virol. 1998 Jul;72(7):5877-85 PMID: 9621049
  7. First snapshots of the HIV-1 RNA structure in infected cells and in virions.
    J Biol Chem. 2004 Nov 12;279(46):48397-403 PMID: 15355993
  8. HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region.
    Cell. 1990 Feb 23;60(4):685-93 PMID: 1689218
  9. cis Acting RNA sequences control the gag-pol translation readthrough in murine leukemia virus.
    Virology. 1991 Jul;183(1):313-9 PMID: 2053284
  10. HIV protease cleaves poly(A)-binding protein.
    Biochem J. 2006 Jun 1;396(2):219-26 PMID: 16594896
  11. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team.
    N Engl J Med. 1997 Sep 11;337(11):725-33 PMID: 9287227
  12. The 5' RNA terminus of spleen necrosis virus stimulates translation of nonviral mRNA.
    J Virol. 2000 Sep;74(17):8111-8 PMID: 10933721
  13. Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.
    Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11364-9 PMID: 16840558
  14. Translation initiation by factor-independent binding of eukaryotic ribosomes to internal ribosomal entry sites.
    C R Biol. 2005 Jul;328(7):589-605 PMID: 15992743
  15. An Mpsi-containing heterologous RNA, but not env mRNA, is efficiently packaged into avian retroviral particles.
    J Virol. 1999 Nov;73(11):8926-33 PMID: 10515997
  16. Eukaryotic initiation factor 4GI is a poor substrate for HIV-1 proteinase.
    FEBS Lett. 2002 Oct 9;529(2-3):337-40 PMID: 12372624
  17. Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR.
    Science. 1991 Mar 29;251(5001):1597-600 PMID: 2011739
  18. Polypurine (A)-rich sequences promote cross-kingdom conservation of internal ribosome entry.
    Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5301-6 PMID: 11959981
  19. The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region.
    J Virol. 1989 Mar;63(3):1265-74 PMID: 2783738
  20. The first and third uORFs in RSV leader RNA are efficiently translated: implications for translational regulation and viral RNA packaging.
    Nucleic Acids Res. 1995 Mar 11;23(5):861-8 PMID: 7708504
  21. The eukaryotic translation initiation factor 4GI is cleaved by different retroviral proteases.
    J Virol. 2003 Dec;77(23):12392-400 PMID: 14610163
  22. The human immunodeficiency virus type 1 5' packaging signal structure affects translation but does not function as an internal ribosome entry site structure.
    J Virol. 1996 Feb;70(2):944-51 PMID: 8551634
  23. Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection.
    Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11089-94 PMID: 9736694
  24. HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes.
    Virology. 1994 Nov 1;204(2):823-7 PMID: 7524241
  25. HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR.
    Virology. 1995 Nov 10;213(2):413-24 PMID: 7491766
  26. Picornavirus 2A proteinase-mediated stimulation of internal initiation of translation is dependent on enzymatic activity and the cleavage products of cellular proteins.
    Virology. 1995 Nov 10;213(2):549-57 PMID: 7491779
  27. Regulated HIV-2 RNA dimerization by means of alternative RNA conformations.
    Nucleic Acids Res. 2002 Jun 15;30(12):2647-55 PMID: 12060681
  28. Direct interactions between autoantigen La and human immunodeficiency virus leader RNA.
    J Virol. 1994 Nov;68(11):7008-20 PMID: 7933083
  29. The HIV-1 leader RNA conformational switch regulates RNA dimerization but does not regulate mRNA translation.
    Biochemistry. 2005 Jun 28;44(25):9058-66 PMID: 15966729
  30. HIV-2 genomic RNA contains a novel type of IRES located downstream of its initiation codon.
    Nat Struct Mol Biol. 2005 Nov;12(11):1001-7 PMID: 16244661
  31. Internal ribosome entry site-mediated translation of a mammalian mRNA is regulated by amino acid availability.
    J Biol Chem. 2001 Apr 13;276(15):12285-91 PMID: 11114306
  32. Suppression of cap-dependent translation in mitosis.
    Genes Dev. 2001 Aug 15;15(16):2083-93 PMID: 11511540
  33. HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms.
    Arch Biochem Biophys. 2000 Jan 15;373(2):361-7 PMID: 10620360
  34. Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeat.
    J Virol. 1988 Mar;62(3):673-9 PMID: 2828663
  35. The major human immunodeficiency virus type 2 (HIV-2) packaging signal is present on all HIV-2 RNA species: cotranslational RNA encapsidation and limitation of Gag protein confer specificity.
    J Virol. 2001 Dec;75(24):12058-69 PMID: 11711596
  36. The ability of the HIV-1 AAUAAA signal to bind polyadenylation factors is controlled by local RNA structure.
    Nucleic Acids Res. 1999 Jan 15;27(2):446-54 PMID: 9862964
  37. Function of the human immunodeficiency virus types 1 and 2 Rev proteins is dependent on their ability to interact with a structured region present in env gene mRNA.
    J Virol. 1990 Sep;64(9):4428-37 PMID: 2200888
  38. La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA.
    J Virol. 1994 Nov;68(11):7001-7 PMID: 7933082
  39. The HIV-1 Rev protein: a model system for coupled RNA transport and translation.
    New Biol. 1991 Dec;3(12):1220-32 PMID: 1725960
  40. Identification of an internal ribosome entry segment in the 5' region of the mouse VL30 retrotransposon and its use in the development of retroviral vectors.
    J Virol. 1999 Oct;73(10):8393-402 PMID: 10482590
  41. The human immunodeficiency virus type 1 gag gene encodes an internal ribosome entry site.
    J Virol. 2001 Jan;75(1):181-91 PMID: 11119587
  42. IRESdb: the Internal Ribosome Entry Site database.
    Nucleic Acids Res. 2003 Jan 1;31(1):427-8 PMID: 12520041
  43. Maintenance of the Gag/Gag-Pol ratio is important for human immunodeficiency virus type 1 RNA dimerization and viral infectivity.
    J Virol. 2001 Feb;75(4):1834-41 PMID: 11160682
  44. Retrovirus translation initiation: Issues and hypotheses derived from study of HIV-1.
    Curr HIV Res. 2006 Apr;4(2):131-9 PMID: 16611053
  45. Characterization of two distinct RNA domains that regulate translation of the Drosophila gypsy retroelement.
    RNA. 2004 Mar;10(3):504-15 PMID: 14970395
  46. Characterization of an internal ribosomal entry segment within the 5' leader of avian reticuloendotheliosis virus type A RNA and development of novel MLV-REV-based retroviral vectors.
    Hum Gene Ther. 1997 Nov 1;8(16):1855-65 PMID: 9382952
  47. Frameshift and intragenic suppressor mutations in a Rous sarcoma provirus suggest src encodes two proteins.
    Cell. 1983 Mar;32(3):871-9 PMID: 6299579
  48. An internal ribosomal entry signal in the rat VL30 region of the Harvey murine sarcoma virus leader and its use in dicistronic retroviral vectors.
    J Virol. 1995 Oct;69(10):6400-7 PMID: 7666541
  49. Murine leukemia virus protease is encoded by the gag-pol gene and is synthesized through suppression of an amber termination codon.
    Proc Natl Acad Sci U S A. 1985 Mar;82(6):1618-22 PMID: 3885215
  50. The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E.
    EMBO J. 1996 Mar 15;15(6):1371-82 PMID: 8635470
  51. Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.
    Proc Natl Acad Sci U S A. 1990 Feb;87(3):1198-202 PMID: 2405396
  52. Characterization of the solution complex between the interferon-induced, double-stranded RNA-activated protein kinase and HIV-I trans-activating region RNA.
    J Biol Chem. 1997 Apr 4;272(14):9510-6 PMID: 9083092
  53. Characterization of an efficient coronavirus ribosomal frameshifting signal: requirement for an RNA pseudoknot.
    Cell. 1989 May 19;57(4):537-47 PMID: 2720781
  54. A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression.
    Biochimie. 1996;78(11-12):1075-80 PMID: 9150887
  55. Regulation of cap-dependent translation by eIF4E inhibitory proteins.
    Nature. 2005 Feb 3;433(7025):477-80 PMID: 15690031
  56. A nonstructural gag-encoded glycoprotein precursor is necessary for efficient spreading and pathogenesis of murine leukemia viruses.
    J Virol. 1994 Jun;68(6):3857-67 PMID: 8189523
  57. In vitro evidence for a long range pseudoknot in the 5'-untranslated and matrix coding regions of HIV-1 genomic RNA.
    J Biol Chem. 2002 Feb 22;277(8):5995-6004 PMID: 11744696
  58. Specific binding of a basic peptide from HIV-1 Rev.
    EMBO J. 1992 Mar;11(3):1119-29 PMID: 1547776
  59. Role of the open reading frames of Rous sarcoma virus leader RNA in translation and genome packaging.
    EMBO J. 1992 Oct;11(10):3747-57 PMID: 1327749
  60. Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism.
    Cell. 1989 Jan 27;56(2):303-12 PMID: 2536299
  61. Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia.
    Mol Biol Cell. 2002 May;13(5):1792-801 PMID: 12006670
  62. Internal ribosome initiation of translation and the control of cell death.
    Trends Genet. 2000 Oct;16(10):469-73 PMID: 11050335
  63. A molecular rheostat. Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression.
    J Mol Biol. 1994 Aug 12;241(2):193-207 PMID: 8057359
  64. Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
    PLoS Pathog. 2006 Mar;2(3):e25 PMID: 16609730
  65. HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation.
    Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12966-71 PMID: 11606767
  66. Cell killing by HIV-1 protease.
    J Biol Chem. 2003 Jan 10;278(2):1086-93 PMID: 12370191
  67. A study of the dimer formation of Rous sarcoma virus RNA and of its effect on viral protein synthesis in vitro.
    Nucleic Acids Res. 1990 Jan 11;18(1):119-27 PMID: 2155394
  68. HIV capsid assembly.
    Curr HIV Res. 2003 Jan;1(1):1-14 PMID: 15043208
  69. Interaction of Staufen1 with the 5' end of mRNA facilitates translation of these RNAs.
    Nucleic Acids Res. 2005 Aug 26;33(15):4797-812 PMID: 16126845
  70. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia.
    Mol Cell Biol. 1998 Jun;18(6):3112-9 PMID: 9584152
  71. An internal ribosome entry segment promotes translation of the simian immunodeficiency virus genomic RNA.
    J Biol Chem. 2000 Apr 21;275(16):11899-906 PMID: 10766817
  72. Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo.
    Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9445-9 PMID: 7568151
  73. CUG initiation codon used for the synthesis of a cell surface antigen coded by the murine leukemia virus.
    J Mol Biol. 1989 Jan 20;205(2):363-72 PMID: 2538626
  74. Functions of the 5' leader of murine leukemia virus genomic RNA in virion structure, viral replication and pathogenesis, and MLV-derived vectors.
    Biochimie. 1996;78(7):632-8 PMID: 8955906
  75. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy.
    N Engl J Med. 1997 Sep 11;337(11):734-9 PMID: 9287228
  76. In vitro evidence that the untranslated leader of the HIV-1 genome is an RNA checkpoint that regulates multiple functions through conformational changes.
    J Biol Chem. 2002 May 31;277(22):19967-75 PMID: 11896057
  77. Multiple secondary structure rearrangements during HIV-1 RNA dimerization.
    Biochemistry. 2002 Aug 20;41(33):10439-45 PMID: 12173930
  78. Construction and applications of a highly transmissible murine retrovirus shuttle vector.
    Cell. 1984 Jul;37(3):1053-62 PMID: 6331674
  79. Translation is not required To generate virion precursor RNA in human immunodeficiency virus type 1-infected T cells.
    J Virol. 2000 Dec;74(24):11531-7 PMID: 11090150
  80. Destiny of unspliced retroviral RNA: ribosome and/or virion?
    J Virol. 2002 Apr;76(7):3089-94 PMID: 11884533
  81. Continuous heat shock enhances translational initiation directed by internal ribosomal entry site.
    Biochem Biophys Res Commun. 2002 Sep 20;297(2):224-31 PMID: 12237106
  82. RU5 of Mason-Pfizer monkey virus 5' long terminal repeat enhances cytoplasmic expression of human immunodeficiency virus type 1 gag-pol and nonviral reporter RNA.
    J Virol. 2002 Oct;76(20):10211-8 PMID: 12239296
  83. Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein.
    Cell. 1987 Feb 27;48(4):691-701 PMID: 3643816
  84. Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs.
    Genes Dev. 1991 May;5(5):808-19 PMID: 1827422
  85. In vitro cleavage of eIF4GI but not eIF4GII by HIV-1 protease and its effects on translation in the rabbit reticulocyte lysate system.
    J Mol Biol. 2002 Apr 19;318(1):9-20 PMID: 12054764
  86. The HIV lipidome: a raft with an unusual composition.
    Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2641-6 PMID: 16481622
  87. Regulation of HIV-1 env mRNA translation by Rev protein.
    Biochim Biophys Acta. 2005 Mar 22;1743(1-2):169-75 PMID: 15777852
  88. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
    Annu Rev Biochem. 1999;68:913-63 PMID: 10872469
  89. IRESite: the database of experimentally verified IRES structures (www.iresite.org).
    Nucleic Acids Res. 2006 Jan 1;34(Database issue):D125-30 PMID: 16381829
  90. Analysis of synergy between divergent simple retrovirus posttranscriptional control elements.
    Virology. 2003 Dec 5;317(1):146-54 PMID: 14675633
  91. RNA helicase A is necessary for translation of selected messenger RNAs.
    Nat Struct Mol Biol. 2006 Jun;13(6):509-16 PMID: 16680162
  92. A Role of RNA Helicase A in cis-Acting Transactivation Response Element-mediated Transcriptional Regulation of Human Immunodeficiency Virus Type 1.
    J Biol Chem. 2001 Feb 23;276(8):5445-51 PMID: 11096080
  93. A minimal avian retroviral packaging sequence has a complex structure.
    J Virol. 1998 Jul;72(7):6190-4 PMID: 9621088
  94. Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G.
    EMBO J. 1996 Dec 16;15(24):7168-77 PMID: 9003792
  95. A novel long distance base-pairing interaction in human immunodeficiency virus type 1 RNA occludes the Gag start codon.
    J Biol Chem. 2003 Mar 28;278(13):11601-11 PMID: 12458192
  96. Internal ribosome entry sites in cellular mRNAs: mystery of their existence.
    J Biol Chem. 2005 Jun 24;280(25):23425-8 PMID: 15749702
  97. Alternative translation initiation of the Moloney murine leukemia virus mRNA controlled by internal ribosome entry involving the p57/PTB splicing factor.
    J Biol Chem. 1995 Sep 1;270(35):20376-83 PMID: 7657611
  98. Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region.
    Cell. 1988 Nov 4;55(3):447-58 PMID: 2846182
  99. Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product.
    Science. 1990 Mar 9;247(4947):1216-9 PMID: 2180064
  100. The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat.
    Cell. 1985 Jul;41(3):813-23 PMID: 2988790
  101. Alternative mechanisms of initiating translation of mammalian mRNAs.
    Biochem Soc Trans. 2005 Dec;33(Pt 6):1231-41 PMID: 16246087
  102. The glycosylated gag protein of MuLV is a determinant of neuroinvasiveness: analysis of second site revertants of a mutant MuLV lacking expression of this protein.
    Virology. 1996 Dec 15;226(2):384-92 PMID: 8955058
  103. Dimerization of retroviral RNA genomes: an inseparable pair.
    Nat Rev Microbiol. 2004 Jun;2(6):461-72 PMID: 15152202
  104. Mutational analysis of the 5' non-coding region of human immunodeficiency virus type 1: effects of secondary structure on translation.
    EMBO J. 1988 Sep;7(9):2831-7 PMID: 3181141
  105. Identification of a high-affinity RNA-binding site for the human immunodeficiency virus type 1 Rev protein.
    Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):758-62 PMID: 1731351
  106. Rous sarcoma virus translation revisited: characterization of an internal ribosome entry segment in the 5' leader of the genomic RNA.
    J Virol. 2000 Dec;74(24):11581-8 PMID: 11090156
  107. A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting.
    Nature. 2006 May 11;441(7090):244-7 PMID: 16688178
  108. Structure and function of the human immunodeficiency virus leader RNA.
    Prog Nucleic Acid Res Mol Biol. 1996;54:1-34 PMID: 8768071
  109. Sequence-specific RNA binding by the HIV-1 Rev protein.
    Nature. 1989 Dec 7;342(6250):714-6 PMID: 2556643
  110. Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.
    J Exp Pathol. 1990;5(2):69-77 PMID: 1708818
  111. Recognition of the high affinity binding site in rev-response element RNA by the human immunodeficiency virus type-1 rev protein.
    Nucleic Acids Res. 1992 Dec 25;20(24):6465-72 PMID: 1282702
  112. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation.
    J Biol Chem. 1995 Sep 15;270(37):21975-83 PMID: 7665619
  113. A structural linkage between the dimerization and encapsidation signals in HIV-2 leader RNA.
    RNA. 2003 Aug;9(8):1007-18 PMID: 12869711
  114. Vpr-induced cell cycle arrest is conserved among primate lentiviruses.
    J Virol. 1996 Apr;70(4):2516-24 PMID: 8642681
  115. Assembling the human immunodeficiency virus type 1.
    Cell Mol Life Sci. 2002 Jul;59(7):1166-84 PMID: 12222963
  116. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.
    EMBO J. 1998 Dec 15;17(24):7480-9 PMID: 9857202
  117. RNA interactions in the 5' region of the HIV-1 genome.
    J Mol Biol. 2004 Feb 13;336(2):369-79 PMID: 14757051
  118. Human immunodeficiency virus type 1 Gag polyprotein modulates its own translation.
    J Virol. 2006 Nov;80(21):10478-86 PMID: 17041220
  119. Protein synthesis in eukaryotes: the growing biological relevance of cap-independent translation initiation.
    Biol Res. 2005;38(2-3):121-46 PMID: 16238092
  120. HIV-1 TAR RNA: the target of molecular interactions between the virus and its host.
    Curr HIV Res. 2005 Jan;3(1):61-71 PMID: 15638724
  121. Takeover of host ribosomes by divergent IRES elements.
    Biochem Soc Trans. 2005 Dec;33(Pt 6):1479-82 PMID: 16246150
  122. Initiation of protein synthesis in eukaryotic cells.
    Eur J Biochem. 1996 Mar 15;236(3):747-71 PMID: 8665893
  123. Molecular mechanisms of translation initiation in eukaryotes.
    Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7029-36 PMID: 11416183
  124. HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA.
    Cell. 1991 Nov 1;67(3):529-36 PMID: 1934059
  125. Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection.
    J Virol. 1999 Apr;73(4):3467-72 PMID: 10074204
  126. An internal ribosomal entry mechanism promotes translation of murine leukemia virus gag polyprotein precursors.
    J Virol. 1995 Apr;69(4):2214-22 PMID: 7884868
  127. The 5' and 3' TAR elements of human immunodeficiency virus exert effects at several points in the virus life cycle.
    J Virol. 1998 Nov;72(11):9217-23 PMID: 9765469
  128. Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription.
    Oncogene. 1998 Jul 16;17(2):227-36 PMID: 9674707
  129. The scanning model for translation: an update.
    J Cell Biol. 1989 Feb;108(2):229-41 PMID: 2645293
  130. Synthesis of murine leukemia virus proteins associated with virions assembled in actinomycin D-treated cells: evidence for persistence of viral messenger RNA.
    Proc Natl Acad Sci U S A. 1976 Apr;73(4):1154-8 PMID: 57617
  131. The 2-5A system and HIV infection.
    Prog Mol Subcell Biol. 1994;14:176-97 PMID: 7914804
  132. Direct evidence for translational regulation by leader RNA and Tat protein of human immunodeficiency virus type 1.
    Proc Natl Acad Sci U S A. 1990 Oct;87(19):7492-6 PMID: 2120701
  133. Mutations in the TAR hairpin affect the equilibrium between alternative conformations of the HIV-1 leader RNA.
    Nucleic Acids Res. 2001 Jun 15;29(12):2594-600 PMID: 11410668
  134. The leader of human immunodeficiency virus type 1 genomic RNA harbors an internal ribosome entry segment that is active during the G2/M phase of the cell cycle.
    J Virol. 2003 Apr;77(7):3939-49 PMID: 12634354
  135. The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs.
    Mol Cell Biol. 1992 Mar;12(3):1375-86 PMID: 1545819
  136. Characterization of a novel RNA-binding region of eIF4GI critical for ribosomal scanning.
    EMBO J. 2003 Apr 15;22(8):1909-21 PMID: 12682023
  137. An internal ribosome entry site promotes translation of a novel SIV Pr55(Gag) isoform.
    Virology. 2006 Jun 5;349(2):325-34 PMID: 16494914
  138. Structure-function relationship of Rous sarcoma virus leader RNA.
    Nucleic Acids Res. 1982 Sep 11;10(17):5183-96 PMID: 6292833
  139. c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis.
    Mol Cell Biol. 2000 Feb;20(4):1162-9 PMID: 10648601
  140. Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin.
    J Virol. 1995 Jun;69(6):3465-74 PMID: 7745693
  141. Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2.
    Nucleic Acids Res. 2000 Feb 15;28(4):1011-8 PMID: 10648795
  142. The 5' RNA terminus of spleen necrosis virus contains a novel posttranscriptional control element that facilitates human immunodeficiency virus Rev/RRE-independent Gag production.
    J Virol. 1999 Jun;73(6):4847-55 PMID: 10233946
Article Info
Journal
Nature reviews. Microbiology
Abbr.
Nat Rev Microbiol
ISSN
1740-1534
DOI
10.1038/nrmicro1599
Published
2007-02-00
Pages
128-40
Language
English
Region
England
NLM ID
101190261
PMCID
PMC7096986
Subset
IM
External Links
PubMed source DOI: 10.1038/nrmicro1599 PMC Full Text View journal details
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